Determine the necessary mass, volume, or concentration for preparing a solution.
10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 2 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
N-Maleoyl-β-alanine (3- maleimide propionic acid) is an aliphatic N-substituted maleimide. It is one of the components of EC145 (a folate-targeted vinca alkaloid conjugate) stable solution used for pharmacokinetic study of rodents.
N-Maleoyl-β-alanine (3- maleimide propionic acid, N -(2- carboxyethyl) maleimide) is a suitable reagent used in the following research:
The biotin binding affinity of Avd (S16C) (avidin with single point mutation S16C) was decreased.
As a side chain reaction agent, the trypsin peptide was modified, resulting in mass shift, indicating the presence of cysteine residues.
Cysteine exposed by Xenopus oocytes was blocked in advance and used as an expression system to study the conformational changes of cASIC1a receptor.
It can be used for the following research:
As a protective agent for keratin fibers in high temperature process.
As an unbreakable maleimide group in the synthesis process of four-walled molecular umbrella-octa-arginine conjugate.
Synthesis of N-Maleoyl-β-Organotin Carboxylate-Alanine.
Interaction between functionalized gold surface and cysteine modified peptide.
Preparation of crosslinked dextran-polyethylene glycol hydrogel matrix.
| Canonical Smiles | C1=CC(=O)N(C1=O)CCC(=O)O |
|---|---|
| IUPAC Name | 3-(2,5-dioxopyrrol-1-yl)propanoic acid |
| InChIKey | IUTPJBLLJJNPAJ-UHFFFAOYSA-N |
| INCHI | 1S/C7H7NO4/c9-5-1-2-6(10)8(5)4-3-7(11)12/h1-2H,3-4H2,(H,11,12) |
| Isomeric SMILES | C1=CC(=O)N(C1=O)CCC(=O)O |
| WGK Germany | 3 |
| Molecular Weight | 169.13 |
| Beilstein | 1528952 |
| Reaxy-Rn | 1528952 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1528952&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Pyrrolidines |
| Subclass | Pyrrolidones |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Maleimides |
| Alternative Parents | N-substituted carboxylic acid imides Pyrrolines Dicarboximides Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aliphatic heteromonocyclic compounds |
| Substituents | Maleimide - Carboxylic acid imide, n-substituted - Carboxylic acid imide - Dicarboximide - Pyrroline - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Azacycle - Carbonyl group - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aliphatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as maleimides. These are compounds containing a 2,5-pyrroledione moiety. |
| External Descriptors | Not available |
| Sensitivity | Moisture Sensitive |
|---|---|
| Melt Point(°C) | 110°C |
| Molecular Weight | 169.130 g/mol |
| XLogP3 | 0.000 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 3 |
| Exact Mass | 169.038 Da |
| Monoisotopic Mass | 169.038 Da |
| Topological Polar Surface Area | 74.700 Ų |
| Heavy Atom Count | 12 |
| Formal Charge | 0 |
| Complexity | 251.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Chongzheng Yan, Ying Liu, Guozhi Zhao, Huatian Yang, Huaiyou Lv, Genju Li, Yuhan Li, Yaqing Fu, Fengqin Sun, Yafei Feng, Yizhe Li, Zhongxi Zhao. (2024) Inhalable metal-organic framework-mediated cuproptosis combined with PD-L1 checkpoint blockade for lung metastasis synergistic immunotherapy. Acta Pharmaceutica Sinica B, [PMID:38799628] [10.1016/j.apsb.2024.01.017] |
| 2. Peng Ding, Yanfang Sun, Guohua Jiang, Lei Nie. (2025) Hydroxyproline-Modified Chitosan-Based Hydrogel Dressing Incorporated with Epigallocatechin-3-Gallate Promotes Wound Healing Through Immunomodulation. Gels, 11 (9): (732). [PMID:41002506] [10.3390/gels11090732] |