VU 0361737 - Moligand™, 10mM in DMSO , Allosteric modulator of mGlu 4 receptor, CAS No.1161205-04-4, Allosteric modulator of mGlu 4 receptor

CAS: 1161205-04-4 Cat. No.: V408336 Molecular Weight: 262.69 EC Number: 802-357-5 PubChem CID: 44191096

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

2-Pyridinecarboxamide, N-(4-chloro-3-methoxyphenyl)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

VU 0361737 is a selective positive allosteric modulator (PAM) formGlu4receptor withEC50of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7
In vitro

VU0361737 is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors.

In vivo

VU0361737 shows high in vivo CL in rat, a short half-life (T_1/2 20 min), and demonstrates significant brain exposure (brain-to-plasma ratio of 4.1).
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥100%

Specifications

Synonyms

2-Pyridinecarboxamide, N-(4-chloro-3-methoxyphenyl)-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mG

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ALLOSTERIC MODULATOR

Mechanism of action

Allosteric modulator of mGlu 4 receptor

Names and Identifiers

• Isomeric SMILES: COC1=C(C=CC(=C1)NC(=O)C2=CC=CC=N2)Cl
• WGK Germany: 3
• PubChem CID: 44191096
• Molecular Weight: 262.69

Associated Targets(Human)

GRM4 Tchem Metabotropic glutamate receptor 4 (3 Activities)

Discover Target: GRM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 58 mg/mL (199.49 mM)