UAMC-3203 - 10mM in DMSO , CAS No.2271358-64-4

CAS: 2271358-64-4 Cat. No.: U408498 Molecular Weight: 471.66 PubChem CID: 137701965

GRADE & PURITY 10mM in DMSO

Synonyms

Benzenesulfonamide, 4-​(cyclohexylamino)​-​3-​[(phenylmethyl)​amino]​-​N-​[2-​(1-​piperazinyl)​ethyl]​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

UAMC-3203 UAMC-3203 is an improved ferroptosis inhibitor with an IC50 value of 10 nM in IMR-32 neuroblastoma cells.
In vitro

UAMC-3203 has an impressive t1/2 when incubated with both human and rat microsomes (t1/2 = 20.5 h and t1/2 = 16.5 h respectively) but is found to be relatively less stable when incubated with murine microsomes (t1/2 = 3.46 h).

In vivo

UAMC-3203 significantly lowers the plasma levels of lactate dehydrogenase (LDH) in mice. It is rapidly removed from the bloodstream and redistributed into various tissues, as can be expected for lipophilic basic compounds. Significant concentrations of UAMC-3203 are found in all analyzed tissues (liver, kidney, and lungs).
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Synonyms

Benzenesulfonamide, 4-​(cyclohexylamino)​-​3-​[(phenylmethyl)​amino]​-​N-​[2-​(1-​piperazinyl)​ethyl]​-

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

UAMC-3203 is an improved ferroptosis inhibitor with an IC50 value of 10 nM in IMR-32 neuroblastoma cells.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Product Properties

• ALogP: 3.36
• HBD Count: 4
• Rotatable Bond: 10

Names and Identifiers

• Isomeric SMILES: C1CCC(CC1)NC2=C(C=C(C=C2)S(=O)(=O)NCCN3CCNCC3)NCC4=CC=CC=C4
• PubChem CID: 137701965
• Molecular Weight: 471.66

Chemical and Physical Properties

• DMSO(mg / mL) Max Solubility: 94
• DMSO(mM) Max Solubility: 199.296103125133
• Water(mg / mL) Max Solubility: ＜1