2-Deoxy-D-glucose - ≥98% , CAS No.154-17-6

CAS: 154-17-6 Cat. No.: D109194 Peso molecular: 164.16 Beilstein Registry Number: 1723331 Número EC: 205-823-0

GRADE & PURITY ≥98%

Synonyms

5CFA0332-FB70-485D-A064-6C4C39E7CBA1 | 2 Deoxy D glucose | 2-DEOXY-D-GLUCOSE [HSDB] | EINECS 205-823-0 | 2-Deoxy-D-mannose | 2-Deoxy-D-arabino-hexose;D-Arabino-2-deoxyhexose | 3,3-bis(4-hydroxy-2-methyl-5-propan-2-ylphenyl)-2-benzouran-1-one | D-2-Deoxygl

Storage

Store at 2-8°C

Shipped In

Wet ice

Descripción general

2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.

Specifications

Sinónimos

5CFA0332-FB70-485D-A064-6C4C39E7CBA1 | 2 Deoxy D glucose | 2-DEOXY-D-GLUCOSE [HSDB] | EINECS 205-823-0 | 2-Deoxy-D-mannose | 2-Deoxy-D-arabino-hexose;D-Arabino-2-deoxyhexose | 3, 3-bis(4-hydroxy-2-methyl-5-propan-2-ylphenyl)-2-benzouran-1-one | D-2-Deoxygl

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its action on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomera

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 488187422
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488187422
• Sonrisas canónicas: C(C=O)C(C(C(CO)O)O)O
• IUPAC Name: (3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal
• InChIKey: VRYALKFFQXWPIH-PBXRRBTRSA-N
• INCHI: 1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1
• Isómeros SMILES: C(C=O)[C@H]([C@@H]([C@@H](CO)O)O)O
• WGK Alemania: 3
• RTECS: MQ3325000
• Peso molecular: 164.16
• Beilstein: 1723331
• Reaxy-Rn: 2041872
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2041872&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Clase Fatty Acyls
      • Subclass Fatty alcohols

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Clase: Fatty Acyls
• Subclass: Fatty alcohols
• Intermediate Tree Nodes: Not available
• Direct Parent: Fatty alcohols
• Alternative Parents: Medium-chain aldehydes Beta-hydroxy aldehydes Alpha-hydrogen aldehydes Secondary alcohols Polyols Primary alcohols Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Fatty alcohol - Medium-chain aldehyde - Beta-hydroxy aldehyde - Alpha-hydrogen aldehyde - Secondary alcohol - Polyol - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Primary alcohol - Organooxygen compound - Carbonyl group - Aldehyde - Alcohol - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as fatty alcohols. These are aliphatic alcohols consisting of a chain of a least six carbon atoms.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

SLC16A1 Tchem Monocarboxylate transporter 1 (146 Activities)

Discover Target: SLC16A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Soluble in water.
• Rotación específica [α]: 46.5 ° (C=1, H2O)
• Punto de fusión (°C): 146-147°C
• Peso molecular: 164.160 g/mol
• XLogP3: -2.900
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 164.068 Da
• Monoisotopic Mass: 164.068 Da
• Topological Polar Surface Area: 98.000 Ų
• Heavy Atom Count: 11
• Formal Charge: 0
• Complexity: 116.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 3
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

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