4-Hydroxynonenal (4-HNE) - Moligand™, ≥97% , Activator of TRPA1, CAS No.75899-68-2, Activator of TRPA1

CAS: 75899-68-2 Cat. No.: H274882 Peso molecular: 156.22
Disponible para pedir
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
Synonyms
HY-113466 | UNII-K1CVM13F96 | CCRIS 6927 | (+/-)4-HYDROXYNON-2-ENAL | (2E)-4-hydroxynon-2-enal | NCGC00161254-01 | 4-hydroxynon-2-enal | HNE [MI] | M01859 | HSCI1_000340 | EX-A5735 | (E)-4-hydroxynon-2-enal | PD021010 | MS-22883 | (E)-4-Hydroxynonenal | D
Storage
Protected from light,Store at -20°C,Argon charged,Desiccated
Shipped In
Ice chest + Ice pads
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
1mg
H274882-1mg
3
45,90US$
5mg
H274882-5mg
2
89,90US$
25mg
H274882-25mg
1
299,90US$
50mg
H274882-50mg
1
499,90US$
100mg
H274882-100mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
719,90US$
Enter a quantity for the sizes you want to add.
🧪

Why this grade

Moligand™, ≥97% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Protected from light,Store at -20°C,Argon charged,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.

Specifications

Sinónimos
HY-113466 | UNII-K1CVM13F96 | CCRIS 6927 | (+/-)4-HYDROXYNON-2-ENAL | (2E)-4-hydroxynon-2-enal | NCGC00161254-01 | 4-hydroxynon-2-enal | HNE [MI] | M01859 | HSCI1_000340 | EX-A5735 | (E)-4-hydroxynon-2-enal | PD021010 | MS-22883 | (E)-4-Hydroxynonenal | D
Especificaciones y pureza
Moligand™, ≥97%
Mecanismos bioquímicos y fisiológicos
Marker of lipid peroxidation. Prevents NF-κB activation and TNF expression by inhibiting IκB phosphorylation. Range of biological effects such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity. Active in vivo .
Condiciones de almacenamiento de almacenamiento
Protected from light, Store at -20°C, Argon charged, Desiccated
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Tipo de acción
ACTIVATOR
Mecanismo de acción
Activator of TRPA1
Nota
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Pureza
≥97%
Nombres e identificadores
Pubchem Sid488195274
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488195274
Sonrisas canónicasCCCCCC(C=CC=O)O
IUPAC Name(E)-4-hydroxynon-2-enal
InChIKeyJVJFIQYAHPMBBX-FNORWQNLSA-N
INCHI1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3/b7-5+
Isómeros SMILES CCCCCC(/C=C/C=O)O
Peso molecular 156.22
Reaxy-Rn 1931593
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1931593&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassLipids and lipid-like molecules
ClaseFatty Acyls
SubclassFatty alcohols
Intermediate Tree Nodes Not available
Direct ParentFatty alcohols
Alternative Parents Medium-chain aldehydes  Enals  Secondary alcohols  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAliphatic acyclic compounds
Substituents Fatty alcohol - Medium-chain aldehyde - Enal - Alpha,beta-unsaturated aldehyde - Secondary alcohol - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Aldehyde - Alcohol - Aliphatic acyclic compound
DescripciónThis compound belongs to the class of organic compounds known as fatty alcohols. These are aliphatic alcohols consisting of a chain of a least six carbon atoms.
External Descriptors Fatty aldehydes
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GSTA4 Tbio Glutathione S-transferase A4 (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GAPDH Tchem Glyceraldehyde-3-phosphate dehydrogenase liver (1284 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Objetivos asociados (no humanos)
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trpa1 Transient receptor potential cation channel subfamily A member 1 (1003 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Spinal cord (22 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

26 results found

Lot NumberCertificate TypeFechaArticulo
B2302685Certificate of AnalysisJun 11, 2026 H274882
B2302699Certificate of AnalysisMay 20, 2026 H274882
B2302518Certificate of AnalysisMar 18, 2026 H274882
F2625564Certificate of AnalysisFeb 10, 2026 H274882
F2625550Certificate of AnalysisFeb 10, 2026 H274882
F2625549Certificate of AnalysisFeb 10, 2026 H274882
A2619003Certificate of AnalysisJan 24, 2026 H274882
B2506772Certificate of AnalysisOct 30, 2025 H274882
B2506773Certificate of AnalysisOct 30, 2025 H274882
B2506784Certificate of AnalysisOct 30, 2025 H274882
B2506785Certificate of AnalysisOct 30, 2025 H274882
B2302698Certificate of AnalysisOct 13, 2025 H274882
J2331335Certificate of AnalysisAug 15, 2024 H274882
J2331334Certificate of AnalysisAug 15, 2024 H274882
J2331330Certificate of AnalysisAug 14, 2024 H274882
J2331331Certificate of AnalysisAug 14, 2024 H274882
J2331332Certificate of AnalysisAug 14, 2024 H274882
J2331333Certificate of AnalysisAug 14, 2024 H274882
B2302697Certificate of AnalysisNov 10, 2023 H274882
B2302691Certificate of AnalysisNov 26, 2022 H274882
B2302684Certificate of AnalysisNov 26, 2022 H274882
F2211057Certificate of AnalysisJun 05, 2022 H274882
F2211059Certificate of AnalysisJun 05, 2022 H274882
F2211060Certificate of AnalysisJun 05, 2022 H274882
F2211048Certificate of AnalysisJun 05, 2022 H274882
A2218514Certificate of AnalysisJan 08, 2022 H274882

Show more ⌵

Propiedades químicas y físicas
SolubilidadSoluble in ethanol to 100 mM and in DMSO to 100 mM
Sensibilidadair and light sensitive;Moisture sensitive
Peso molecular156.220 g/mol
XLogP31.700
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count6
Exact Mass156.115 Da
Monoisotopic Mass156.115 Da
Topological Polar Surface Area37.300 Ų
Heavy Atom Count11
Formal Charge0
Complexity119.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds1
Covalently-Bonded Unit Count1
Preguntas frecuentes y artículos
Calculadoras de soluciones
Reseñas

Reseñas de cliente

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.