EGS Crosslinker（EGNHS） - ≥96% , CAS No.70539-42-3

CAS: 70539-42-3 Cat. No.: E595347 Peso molecular: 456.36

GRADE & PURITY ≥96%

Synonyms

EINECS 203-536-5 | MFCD00049057 | Bis(2,5-dioxopyrrolidin-1-yl) O,O'-ethane-1,2-diyl disuccinate | Bis(2,5-dioxopyrrolidin-1-yl) O,O-ethane-1,2-diyl disuccinate | Butanedioic acid, 1,1'-(1,2-ethanediyl) 4,4'-bis(2,5-dioxo-1-pyrrolidinyl) ester | FT-062629

Storage

Store at 2-8°C

Shipped In

Wet ice

Descripción general

EGS Crosslinker is a cleavable crosslinker which can be cleaved using hydroxyamine. EGS Crosslinkers contain two NHS ester groups which can be reacted with primary amines.

Specifications

Sinónimos

EINECS 203-536-5 | MFCD00049057 | Bis(2, 5-dioxopyrrolidin-1-yl) O, O'-ethane-1, 2-diyl disuccinate | Bis(2, 5-dioxopyrrolidin-1-yl) O, O-ethane-1, 2-diyl disuccinate | Butanedioic acid, 1, 1'-(1, 2-ethanediyl) 4, 4'-bis(2, 5-dioxo-1-pyrrolidinyl) ester | FT-062629

Especificaciones y pureza

≥96%

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥96%

Nombres e identificadores

• Sonrisas canónicas: C1CC(=O)N(C1=O)OC(=O)CCC(=O)OCCOC(=O)CCC(=O)ON2C(=O)CCC2=O
• IUPAC Name: 4-O-(2,5-dioxopyrrolidin-1-yl) 1-O-[2-[4-(2,5-dioxopyrrolidin-1-yl)oxy-4-oxobutanoyl]oxyethyl] butanedioate
• InChIKey: QLHLYJHNOCILIT-UHFFFAOYSA-N
• INCHI: 1S/C18H20N2O12/c21-11-1-2-12(22)19(11)31-17(27)7-5-15(25)29-9-10-30-16(26)6-8-18(28)32-20-13(23)3-4-14(20)24/h1-10H2
• Isómeros SMILES: C1CC(=O)N(C1=O)OC(=O)CCC(=O)OCCOC(=O)CCC(=O)ON2C(=O)CCC2=O
• Peso molecular: 456.36
• Reaxy-Rn: 9167119
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9167119&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Tetracarboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Tetracarboxylic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Tetracarboxylic acids and derivatives
• Alternative Parents: Fatty acid esters Pyrrolidine-2-ones Dicarboximides Lactams Carboxylic acid salts Carboxylic acid esters Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic salts Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Tetracarboxylic acid or derivatives - Fatty acid ester - Fatty acyl - 2-pyrrolidone - Pyrrolidone - Pyrrolidine - Dicarboximide - Lactam - Carboxylic acid salt - Carboxylic acid ester - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organic salt - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aliphatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as tetracarboxylic acids and derivatives. These are carboxylic acids containing exactly four carboxyl groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Sensibilidad: Moisture sensitive.
• Punto de ebullición (°C): 603.40° C at 760 mmHg (Predicted)
• Punto de fusión (°C): 115-133° C
• Peso molecular: 456.400 g/mol
• XLogP3: -2.300
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 12
• Rotatable Bond Count: 15
• Exact Mass: 456.102 Da
• Monoisotopic Mass: 456.102 Da
• Topological Polar Surface Area: 180.000 Ų
• Heavy Atom Count: 32
• Formal Charge: 0
• Complexity: 736.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Jinpeng Lv, Huansha Zhang, Wenhao Yu, Peiwen Jiang, Chuanwei Yin, Wenhui Xu, Yan Cao, Rongyin Gao.  (2026)  Targeting VDAC1-dependent mtDNA release attenuates fibroblast innate immune activation and vitiligo pathogenesis.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:41722540] [10.1016/j.intimp.2026.116411]

2. Lv Jinpeng, Xu Wenhui, Jiang Peiwen, Yu Wenhao, Xue Hui, Hu Nan, Cao Yan, Zhang Huansha, Yin Chuanwei, Gao Rongyin.  (2026)  Mitochondrial DNA release via VDAC1 in keratinocytes: a key driver of innate immunity and vitiligo pathogenesis.  Cell Death & Disease,      [PMID:] [10.1038/s41419-026-08585-5]