Inflammasomes are important cytoplasmic signaling complexes of the innate immune system that sense infection, cellular injury, and metabolic abnormalities. They activate inflammatory Caspases, promote the maturation of IL-1β and IL-18, and drive Gasdermin-mediated pyroptosis. Inflammasomes such ...
Pyroptosis is a proinflammatory form of regulated cell death mediated by pore formation by Gasdermin family proteins. This process is generally initiated by inflammasome assembly and inflammatory caspase activation, leading to increased plasma membrane permeability, cellular swelling and ...
Apoptosis is a form of programmed cell death regulated by genes and protein networks. It mainly functions to eliminate senescent, damaged, abnormally proliferating, or functionally imbalanced cells. Typical apoptosis is characterized by cell shrinkage, chromatin condensation, DNA fragmentation, ...
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