1,700+ technical articles by Aladdin Scientific's scientists on reagent selection, reaction mechanisms, assay design and formulation. New every week.
The liver possesses remarkable but finite regenerative capacity. Extensive hepatectomy, severe steatosis, chronic inflammation, or fibrosis may prevent the residual liver tissue from recovering its function in time, increasing the risk of post-hepatectomy liver failure. A study published in Cell ...
MTAP loss disrupts the methionine salvage pathway, resulting in the accumulation of 5′-methylthioadenosine (MTA) and partial inhibition of PRMT5 activity. Cancer cells consequently enter a state with limited PRMT5 functional reserve and develop greater dependence on residual PRMT5 activity and ...
Immune-inflammatory diseases involve disruption of immune homeostasis, aberrant autoimmunity, and persistent tissue injury and include inflammatory bowel disease, rheumatoid arthritis, multiple sclerosis, and atopic dermatitis. Induced animal models reproduce key pathological processes through ...
Neutrophils not only participate in antimicrobial defense and tissue injury responses but also infiltrate the tumor microenvironment and acquire highly heterogeneous functional states. They can contribute to antitumor immunity while also promoting tumor progression through immunosuppression, ...
Furanocoumarins are a class of tricyclic compounds formed by the further fusion of a five-membered oxygen-containing heterocycle onto the benzene ring of coumarin. Unlike the hydroxylation, methoxylation, or alkylation of simple coumarins, fusion of an aromatic furan ring directly changes the ...
T-cell engagers (TCEs) are immunotherapeutic molecules that simultaneously recognize T cells and specific target cells, thereby inducing directed T-cell cytotoxicity. In cancer research, a classical TCE binds a tumor-cell surface antigen through one arm and T-cell CD3 through the other. This ...
Nucleic acid molecules such as mRNA and siRNA are susceptible to nuclease degradation, cannot readily cross cell membranes, and may become trapped within endosomes after endocytosis. Lipid nanoparticles (LNPs) establish a cytosolic delivery pathway through nucleic acid encapsulation, ...
Pyranocoumarins are a class of compounds formed by the fusion of a six-membered oxygen-containing heterocycle to a coumarin scaffold. The fusion position of the six-membered oxygen-containing ring, the degree of saturation of the carbon–carbon double bond within the ring, and the substituents ...
Phosphomutases are enzymes that catalyze the intramolecular relocation of phosphate groups. They participate extensively in glycogen metabolism, glycolysis, nucleoside metabolism, and nucleotide-sugar biosynthesis. Under the Enzyme Commission classification system, these enzymes are primarily ...