1,700+ technical articles by Aladdin Scientific's scientists on reagent selection, reaction mechanisms, assay design and formulation. New every week.
A large part of medicinal chemistry optimization is really “local part replacement”: instead of rebuilding the scaffold from scratch, you swap an aromatic ring/heteroaromatic ring for a functional module with a more suitable hydrogen-bonding fingerprint, more controllable polarity, and more ...
β-Lactamases are a family of enzymes that hydrolyze the β-lactam ring and inactivate β-lactam antibacterial agents, constituting a major molecular basis for acquired bacterial resistance. β-Lactam antibiotics primarily target penicillin-binding proteins (PBPs) and disrupt peptidoglycan ...
If we think of small-molecule drugs as combinations of “functional modules,” N-heterocycles are among the most frequently used modules. A striking change from recent decade-level statistics is that the #1 most frequently occurring N-heterocycle has “passed the baton”—from piperidine to ...
This is exactly where small-molecule chemical probes come in. A chemical probe is not meant to “visualize” a protein; instead, it is used to directly perturb a protein’s function in cells, thereby connecting target perturbation to phenotypic change more reliably.
A recurring tension in medicinal design is this: you want stronger binding, better solubility/exposure, more controllable metabolism and selectivity—without tearing down and rebuilding the entire scaffold. Over the past decade-plus, “small, polar, sp³-rich” four-membered rings—oxetanes ...
7-membered N-heterocycles—as a structural module—are often used because.
In drug discovery, many molecules end up stuck in the same awkward spot: potency is good, but exposure is insufficient; selectivity looks fine, but metabolism is too fast; in vitro is beautiful, yet in vivo distribution is disappointing. In those moments, you usually don’t want to rebuild the ...
In synthetic chemistry, a “useful building block” typically has two hallmarks: it reduces step count when constructing complex structures, and it continues to create value through downstream transformations.
Trehalose is a non-reducing disaccharide composed of two glucose units linked by an α,α-1,1-glycosidic bond. It exhibits good chemical stability and formulation compatibility across a range of processing and storage conditions. Owing to its moisturizing capability, anti-freezing and ...