1,700+ technical articles by Aladdin Scientific's scientists on reagent selection, reaction mechanisms, assay design and formulation. New every week.
Imidazole is a five-membered aromatic heterocyclic compound with two nitrogen atoms. The hydrogen atom moves between the two nitrogen atoms, so there are two reciprocal isomers. Imidazole is not only present as histidine in living organisms, but is also a constituent of ribonucleic acid (RNA) ...
C(sp2)- and C(sp)-hybridized coupling reactions are established catalytic approaches. However, multi-step C(sp3)- and C(sp2)-coupling reactions of boronic acids and related derivatives are still limited by ineffective two-electron transmetalation reactions. These conventional protocols exhibit ...
Electron microscopy is essential when studying the complex structure of cells and organelles and studying cellular biological processes. Colloidal gold and its various derivatives have been the most widely used antigen markers in biological electron microscopy. These particles can be attached to ...
TEMPO (2,2,6,6-Tetramethylpiperidine 1-oxyl) and its derivatives play an important role as stabilizing nitroxide radicals for catalysts in organic oxidation reactions. TEMPO was first discovered by Lebedev and Kazarnovskii in 1960. The radical nature of the stabilizing radicals of TEMPO is ...
Ubiquitin is a small protein found in all eukaryotes. The covalent attachment of ubiquitin to intracellular proteins is called ubiquitination.
Nucleic acid therapy, as a prominent, novel and promising therapeutic approach, has potential in the treatment of many genetic diseases such as diabetes.
The Biginelli Reaction is an acid-catalyzed three-component reaction between an aromatic aldehyde, a β-keto ester, and a urea (e.g., urea, thiourea) to produce a tetrahydropyrimidinone with potential pharmaceutical applications.
Macrophage effector function significantly influences the quality, duration, and magnitude of most inflammatory reactions. Traditionally, macrophages have been described as antigen-presenting phagocytes that secrete pro-inflammatory and antimicrobial mediators. Mounting evidence, however, ...
The basic function of acute inflammation is to recruit white blood cells from the circulating blood. These cells are mainly neutrophils, followed by monocytes that can differentiate into macrophages or dendritic cells. Inflammatory reaction is accompanied by the degranulation and activation of ...