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FTY720 (S)-Fosfato - Moligand™, ≥98% , Agonist of S1P 3 receptor, CAS No.402616-26-6, Agonist of S1P 3 receptor

CAS: 402616-26-6 Cat. No.: F347153 Peso molecular: 387.45
COA
FTY720 (S)-Fosfato - Moligand™, ≥98% CAS No(402616-26-6) by Aladdin Scientific
Disponible para pedir
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
HMS2495G03 | DTXSID801127241 | FTY720-phosphate, (S)-2 | [(2S)-2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propoxy]phosphonic acid | Q27088789 | (S)-FTY720P;(S)-FTY720 phosphate | SY025286 | S-fingolimod phosphate ester | BDBM23165 | 92YDM6122J | 1,3-Prop
Storage
Conservar a -20°C
Shipped In
Hielera + almohadillas de hielo
★
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
1mg
F347153-1mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
294,90US$
500μg
F347153-500μg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
155,90US$
5mg
F347153-5mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
999,90US$
Enter a quantity for the sizes you want to add.
Bulk / Custom
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Descripción general Specifications Propiedades del producto Nombres e identificadores Documentation Advanced Data Taxonomic Classification Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Preguntas frecuentes y artículos Calculadoras de soluciones Reseñas
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Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Conservar a -20°C Ships Hielera + almohadillas de hielo Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

El FTY720 (S)-fosfato es un nuevo modulador inmunitario que prolonga la supervivencia de los trasplantes de aloinjertos en numerosos modelos al inhibir la emigración de linfocitos de los órganos linfoides. Fosforilado por esfingosina quinasas in vivo, FTY720 actúa entonces como un potente agonista en EDG-1, EDG-3, EDG-4 y EDG-5 (gen diferencial endotelial). El (S)-fosfato de FTY720 es el único estereoisómero formado por la fosforilación de FTY720 in vivo, según se ha determinado en ratas y seres humanos. Presenta valores Ki de 2,1, 5,9, 23 y 2,2 nM para EDG-1,-3,-4 y -5, respectivamente, mientras que el enantiómero R se une con una afinidad entre 5 y 130 veces menor. El FTY720 (S)-fosfato provoca la internalización de S1P1 en los linfocitos, anulando la salida de linfocitos de los órganos linfoides dependiente de S1P. También mejora la función de la barrera endotelial, estimula la actividad del transportador de esfingosina Abcb1 y del transportador de leucotrieno C4 Abcc16 e inhibe la actividad de la fosfolipasa A2 citosólica.

FTY720 (S)-fosfato es un agonista del receptor 1 de S1P (S1PR1) que puede utilizarse en el estudio de la inflamación aguda, como la lesión pulmonar aguda 添加包装

Specifications

Sinónimos
HMS2495G03 | DTXSID801127241 | FTY720-phosphate, (S)-2 | [(2S)-2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propoxy]phosphonic acid | Q27088789 | (S)-FTY720P;(S)-FTY720 phosphate | SY025286 | S-fingolimod phosphate ester | BDBM23165 | 92YDM6122J | 1, 3-Prop
Especificaciones y pureza
Moligand™, ≥98%
Condiciones de almacenamiento de almacenamiento
Conservar a -20°C
Enviado en
Hielera + almohadillas de hielo
Grado
Moligand™
Tipo de acción
AGONIST
Mecanismo de acción
Agonist of S1P 3 receptor
Pureza
≥98%
Propiedades del producto
pKapKa: 1.73 (Predicted), pKa: 10.04 (Predicted)
Datos KiSIP1: Ki= 2.1 nM; SIP5: Ki= 2.2 nM; SIP3: Ki= 5.9 nM; SIP4: Ki= 23 nM
Nombres e identificadores
Sonrisas canónicasCCCCCCCCC1=CC=C(C=C1)CCC(CO)(COP(=O)(O)O)N
IUPAC Name[(2S)-2-amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl] dihydrogen phosphate
InChIKeyLRFKWQGGENFBFO-IBGZPJMESA-N
INCHI1S/C19H34NO5P/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-25-26(22,23)24/h9-12,21H,2-8,13-16,20H2,1H3,(H2,22,23,24)/t19-/m0/s1
Isómeros SMILES CCCCCCCCC1=CC=C(C=C1)CC[C@](CO)(COP(=O)(O)O)N
Peso molecular 387.45
Reaxy-Rn 9732428
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9732428&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic acids and derivatives
ClaseOrganic phosphoric acids and derivatives
SubclassPhosphate esters
Intermediate Tree Nodes Not available
Direct ParentPhosphoethanolamines
Alternative Parents Monoalkyl phosphates  Aralkylamines  Benzene and substituted derivatives  1,2-aminoalcohols  Primary alcohols  Organic oxides  Monoalkylamines  Hydrocarbon derivatives  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents Phosphoethanolamine - Monoalkyl phosphate - Aralkylamine - Monocyclic benzene moiety - Alkyl phosphate - Benzenoid - 1,2-aminoalcohol - Organic oxygen compound - Alcohol - Primary amine - Primary alcohol - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Amine - Organic oxide - Hydrocarbon derivative - Aromatic homomonocyclic compound
DescripciónThis compound belongs to the class of organic compounds known as phosphoethanolamines. These are compounds containing a phosphate linked to the second carbon of an ethanolamine.
External Descriptors Not available
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
S1PR5 Tclin Sphingosine 1-phosphate receptor 5 (6 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
S1PR2 Tchem Sphingosine 1-phosphate receptor 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
S1PR4 Tclin Sphingosine 1-phosphate receptor 4 (5 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
S1PR1 Tclin Sphingosine 1-phosphate receptor 1 (19 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
S1PR3 Tclin Sphingosine 1-phosphate receptor 3 (17 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CSNK1D Tchem Casein kinase I delta (4546 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
S1PR4 Tclin Sphingosine 1-phosphate receptor Edg-6 (1041 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
S1PR3 Tclin Sphingosine 1-phosphate receptor Edg-3 (2543 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
S1PR2 Tchem Sphingosine 1-phosphate receptor Edg-5 (1593 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
S1PR1 Tclin Sphingosine 1-phosphate receptor Edg-1 (5806 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CDK2 Tchem Cyclin-dependent kinase 2 (9050 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
S1PR5 Tclin Sphingosine 1-phosphate receptor Edg-8 (813 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
C5AR1 Tclin C5a anaphylatoxin chemotactic receptor (2677 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-BR-3 (5175 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U2OS (164939 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SW-620 (52400 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CX3CR1 Tchem C-X3-C chemokine receptor 1 (1686 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FPR2 Tchem Lipoxin A4 receptor (3472 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FFAR4 Tchem G-protein coupled receptor 120 (2999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GPR35 Tchem G-protein coupled receptor 35 (2643 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TRIM24 Tchem Transcription intermediary factor 1-alpha (2087 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BRPF1 Tchem Peregrin (2217 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK-293T (167025 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADGRF1 Tbio Adhesion G-protein coupled receptor F1 (1591 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Objetivos asociados (no humanos)
Aplnr Apelin receptor (201 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gpr119 Glucose-dependent insulinotropic receptor (270 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
S1pr1 Sphingosine 1-phosphate receptor 1 (25 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Liver microsome (341 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
SolubilidadSoluble in chloroform (~0.5 mg/ml), DMSO, and methanol (sparingly). Insoluble in water(at 25° C).
Índice de refracciónn20D1.54 (Predicted)
Punto de ebullición (°C)584.24° C at 760 mmHg (Predicted)
Punto de fusión (°C)195-198° C
Peso molecular387.500 g/mol
XLogP30.800
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count14
Exact Mass387.217 Da
Monoisotopic Mass387.217 Da
Topological Polar Surface Area113.000 Ų
Heavy Atom Count26
Formal Charge0
Complexity409.000
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Preguntas frecuentes y artículos
Role of Sphingolipid Metabolic Remodeling in Apoptotic and Inflammatory Signaling
Categories: Technical articles
Tags:
Apoptosis Fas Ceramide sphingolipid metabolism TRAIL TNFalpha NLRP3 inflammatory signaling
Calculadoras de soluciones
Reseñas

Reseñas de cliente

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View related series

Class A GPCR (8120) GPCR/G Protein (3180) LPL Receptor (115) S1P3 receptor Agonist (14)
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