Guanidine thiocyanate solution - UltraBio™,Suitable for molecular biology,~6 M in H2O , CAS No.593-84-0

CAS: 593-84-0 Cat. No.: G755743 Fórmula: C₂H₆N₄S Peso molecular: 118.16 Beilstein Registry Number: 3563461 Número EC: 209-812-1

GRADE & PURITY UltraBio™, Suitable for molecular biology, ~6 M in H2O

Storage

Room temperature

Shipped In

Normal

Descripción general

Guanidine thiocyanate is a chaotropic agent that functions as a strong protein denaturant. It is widely used in RNA isolation protocols. Guanidine thiocyanate can irreversibly inactivate RNase and DNase and breaks cellular membranes. It dissolves proteins by disturbing their secondary structures. Guanidine thiocyanate also separates nucleoproteins from nucleic acids and aids the digestion of the proteins with proteases. It improves the activity of proteinase K thus making it the protease of choice.

Application:

Guanidine thiocyanate solution has been used to extract:

• plasma RNA from human immunodeficiency virus (HIV)-infected and control patients
• total RNA from collected tissues (shoots, flowers, fruits, and seeds)
• in reverse transcription-polymerase chain reaction (RT-PCR) analysis, RNA from teratocarcinoma cell line (Tera-1)

Specifications

Especificaciones y pureza

UltraBio™,Suitable for molecular biology,~6 M in H2O

Condiciones de almacenamiento de almacenamiento

Room temperature

Enviado en

Normal

Grado

Suitable for molecular biology, UltraBio™

Nombres e identificadores

PH

4.5-7.0 (25 °C)

Sonrisas canónicas

C(#N)S.C(=N)(N)N

IUPAC Name

guanidine;thiocyanic acid

InChIKey

ZJYYHGLJYGJLLN-UHFFFAOYSA-N

INCHI

1S/CH5N3.CHNS/c2-1(3)4;2-1-3/h(H5,2,3,4);3H

Isómeros SMILES

C(#N)S.C(=N)(N)N

WGK Alemania

2

RTECS

XL1225000

Número ONU

1759

Grupo de embalaje

III

Peso molecular

118.16

Beilstein

3563461

Reaxy-Rn

3563461

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3563461&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organosulfur compounds
    • Clase Thiocyanates

• Kingdom: Organic compounds
• Superclass: Organosulfur compounds
• Clase: Thiocyanates
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Thiocyanates
• Alternative Parents: Organopnictogen compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Not available
• Substituents: Thiocyanate - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as thiocyanates. These are salts or esters of thiocyanic acid, with the general formula RSC#N (R=alkyl, aryl).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Punto de fusión (°C): 118-122°C
• Peso molecular: 118.160 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 118.031 Da
• Monoisotopic Mass: 118.031 Da
• Topological Polar Surface Area: 101.000 Ų
• Heavy Atom Count: 7
• Formal Charge: 0
• Complexity: 57.600
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3