Polymyxin B sulfate - pharmaceutical grade, 6,000 USP units/mg , CAS No.1405-20-5

CAS: 1405-20-5 Cat. No.: P105490 Peso molecular: 1301.6 Número EC: 215-774-7

GRADE & PURITY Pharmaceutical grade, 6,000 USP units/mg

Synonyms

AKOS015895662 | HMS2092A07 | BCP12700 | HFMDLUQUEXNBOP-UHFFFAOYSA-N | HMS1920J04 | CCG-39724 | sufuric acid | HMS502E14 | SPECTRUM1500492 | KS-1428 | NCGC00094763-01 | NSC757278 | Pharmakon1600-01500492 | Aerosporin | NCGC00094763-02 | MFCD00131991 | s139

Storage

Store at 2-8°C,Protected from light

Shipped In

Wet ice

Descripción general

Chemical structure: peptide

Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa†. It also has uses studying multidrug-resistant pathogens††, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.
Polymyxin B sulfate salt has been used:
•  in human aortic endothelial cells (HAEC) cell culture to exclude potential endotoxin contamination in recombinant adiponectin
•  in the analysis of the isolates
•  in endotoxin-neutralizing activity of α-amylase (AmyI-1)-18 (LAL assay)

Specifications

Sinónimos

AKOS015895662 | HMS2092A07 | BCP12700 | HFMDLUQUEXNBOP-UHFFFAOYSA-N | HMS1920J04 | CCG-39724 | sufuric acid | HMS502E14 | SPECTRUM1500492 | KS-1428 | NCGC00094763-01 | NSC757278 | Pharmakon1600-01500492 | Aerosporin | NCGC00094763-02 | MFCD00131991 | s139

Especificaciones y pureza

pharmaceutical grade, 6, 000 USP units/mg

Mecanismos bioquímicos y fisiológicos

Polymyxin B is one of the most important antibiotics used to treat gram-negative bacterial infections, including infections caused by carbapenem-resistant non-fermenters and carbapenem-resistant Enterobacteriaceae. Mode of Action: Polymyxin B Sulfate bind

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C, Protected from light

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Pharmaceutical grade

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Nombres e identificadores

• Pubchem Sid: 488195591
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488195591
• Sonrisas canónicas: CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O
• IUPAC Name: N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;sulfuric acid
• InChIKey: HFMDLUQUEXNBOP-UHFFFAOYSA-N
• INCHI: 1S/C56H98N16O13.H2O4S/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79;1-5(2,3)4/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80);(H2,1,2,3,4)
• Isómeros SMILES: CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O
• RTECS: TR1150000
• Peso molecular: 1301.6
• Reaxy-Rn: 24904511
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24904511&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic Polymers
    • Clase Polypeptides

• Kingdom: Organic compounds
• Superclass: Organic Polymers
• Clase: Polypeptides
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Polypeptides
• Alternative Parents: Cyclic peptides Macrolactams N-acyl-alpha amino acids and derivatives Alpha amino acid amides Benzene and substituted derivatives N-acyl amines Organic sulfuric acids Lactams Secondary alcohols Secondary carboxylic acid amides Azacyclic compounds Monoalkylamines Organopnictogen compounds Hydrocarbon derivatives Carbonyl compounds Organic oxides
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Polypeptide - Cyclic alpha peptide - Macrolactam - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Sulfuric acid - Fatty amide - N-acyl-amine - Fatty acyl - Monocyclic benzene moiety - Benzenoid - Organic sulfuric acid or derivatives - Lactam - Carboxamide group - Amino acid or derivatives - Secondary alcohol - Secondary carboxylic acid amide - Carboxylic acid derivative - Organoheterocyclic compound - Azacycle - Organopnictogen compound - Alcohol - Organic nitrogen compound - Primary aliphatic amine - Organonitrogen compound - Carbonyl group - Organooxygen compound - Primary amine - Amine - Organic oxygen compound - Hydrocarbon derivative - Organic oxide - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: Soluble in water at 50mg/ml/n
• Sensibilidad: Light & heat & Moisture sensitive.
• Rotación específica [α]: -80 ° (C=2, H2O)
• Peso molecular: 1301.600 g/mol
• Hydrogen Bond Donor Count: 20
• Hydrogen Bond Acceptor Count: 22
• Rotatable Bond Count: 29
• Exact Mass: 1300.72 Da
• Monoisotopic Mass: 1300.72 Da
• Topological Polar Surface Area: 574.000 Ų
• Heavy Atom Count: 90
• Formal Charge: 0
• Complexity: 2240.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 13
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Referencias

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