Puromycin dihydrochloride - for cell culture, Ready Made Solution, from Streptomyces alboniger,10 mg/mL in H2O , CAS No.58-58-2

CAS: 58-58-2 Cat. No.: P432998 Peso molecular: 544.44 Beilstein Registry Number: 3853613 Número EC: 200-387-8

GRADE & PURITY for Cell culture, Ready Made Solution, from Streptomyces alboniger,10 mg/mL in H2O

Synonyms

EX-A6693 | FS-5016 | SCHEMBL4317 | Adenosine, 3'-(((2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-deoxy-N,N-dimethyl-, dihydrochloride | Puromycin HCl | Tox21_111352 | P-540 | Q7320232 | (S)-3'-((2-Amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-d

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Chemical structure: peptidyl nucleoside

Application

Puromycin is an aminonucleoside antibiotic that is derived from Streptomyces alboniger . It allows selection for cells that contain the resistance gene puromycin N-acetyl-transferase (PAC). It has been used to study vascular smooth muscle cell viability after treatment in the rabbit model . Puromycin is used to produce enhanced green fluorescent protein (EGFP) transgenic piglets after somatic cell cloning and embryo transfer.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Specifications

Sinónimos

EX-A6693 | FS-5016 | SCHEMBL4317 | Adenosine, 3'-(((2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-deoxy-N, N-dimethyl-, dihydrochloride | Puromycin HCl | Tox21_111352 | P-540 | Q7320232 | (S)-3'-((2-Amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-d

Especificaciones y pureza

for cell culture, Ready Made Solution, from Streptomyces alboniger, 10 mg/mL in H2O

Mecanismos bioquímicos y fisiológicos

Mode of Action: Puromycin inhibits protein synthesis by causing premature chain termination acting as an analog of the 3′-terminal end of the aminoacyl-tRNA. Puromycin also acts as a reversible inhibitor of dipeptidyl-peptidase II (serine peptidase) and c

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

for Cell culture

Nombres e identificadores

• Sonrisas canónicas: COC1=CC=C(C[C@H](N)C(=O)NC2[C@@H](CO)O[C@H]([C@H]2O)N2C=NC3=C2N=CN=C3N(C)C)C=C1
• IUPAC Name: (2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide;dihydrochloride
• InChIKey: MKSVFGKWZLUTTO-FZFAUISWSA-N
• INCHI: 1S/C22H29N7O5.2ClH/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12;;/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32);2*1H/t14-,15+,16+,18+,22+;;/m0../s1
• Isómeros SMILES: CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O.Cl.Cl
• WGK Alemania: 3
• RTECS: AU7355000
• CAS alternativo: 53-79-2
• Peso molecular: 544.44
• Beilstein: 3853613
• Reaxy-Rn: 39769009
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=39769009&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Nucleosides, nucleotides, and analogues
    • Clase Purine nucleosides
      • Subclass Purine 3'-deoxyribonucleosides

• Kingdom: Organic compounds
• Superclass: Nucleosides, nucleotides, and analogues
• Clase: Purine nucleosides
• Subclass: Purine 3'-deoxyribonucleosides
• Intermediate Tree Nodes: Not available
• Direct Parent: Purine 3'-deoxyribonucleosides
• Alternative Parents: Phenylalanine and derivatives Alpha amino acid amides Glycosylamines 6-alkylaminopurines Amphetamines and derivatives Pentoses Dialkylarylamines Anisoles Methoxybenzenes Phenoxy compounds Aralkylamines Aminopyrimidines and derivatives Alkyl aryl ethers N-substituted imidazoles Imidolactams Fatty amides Tetrahydrofurans Heteroaromatic compounds Secondary carboxylic acid amides Secondary alcohols Oxacyclic compounds Azacyclic compounds Hydrocarbon derivatives Hydrochlorides Monoalkylamines Organic oxides Organopnictogen compounds Primary alcohols Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Purine 3'-deoxyribonucleoside - Phenylalanine or derivatives - Alpha-amino acid amide - Glycosyl compound - N-glycosyl compound - 6-alkylaminopurine - 6-aminopurine - Alpha-amino acid or derivatives - Amphetamine or derivatives - Pentose monosaccharide - Imidazopyrimidine - Purine - Phenoxy compound - Anisole - Phenol ether - Methoxybenzene - Dialkylarylamine - Aralkylamine - Aminopyrimidine - Alkyl aryl ether - Benzenoid - Fatty acyl - Fatty amide - Monocyclic benzene moiety - Monosaccharide - Pyrimidine - N-substituted imidazole - Imidolactam - Tetrahydrofuran - Imidazole - Heteroaromatic compound - Azole - Secondary alcohol - Carboxamide group - Secondary carboxylic acid amide - Amino acid or derivatives - Carboxylic acid derivative - Ether - Azacycle - Organoheterocyclic compound - Oxacycle - Hydrochloride - Organic oxide - Carbonyl group - Hydrocarbon derivative - Primary aliphatic amine - Alcohol - Organopnictogen compound - Organonitrogen compound - Organooxygen compound - Amine - Primary alcohol - Primary amine - Organic nitrogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as purine 3'-deoxyribonucleosides. These are compounds consisting of a purine linked to a ribose which lacks a hydroxyl group at position 3.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TRPM7 Tchem Transient receptor potential cation channel subfamily M member 7 (19 Activities)

Discover Target: TRPM7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: H2O: soluble 10mg/mL
• Punto de fusión (°C): 174°C(lit.)
• Peso molecular: 544.400 g/mol
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 8
• Exact Mass: 543.176 Da
• Monoisotopic Mass: 543.176 Da
• Topological Polar Surface Area: 161.000 Ų
• Heavy Atom Count: 36
• Formal Charge: 0
• Complexity: 680.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 5
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

Referencias

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