10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 2 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Trifluoperazine (SKF5019) is adopamine D2receptor inhibitor withIC50of 1.1 nM.
In vitro
Trifluoperazine binds to α1A- and α1B-adrenoceptor with Ki value of 27.6 nM and 19.2 nM, respectively, with α1B/α1A ratio of 0.7. Trifluoperazine inhibits Mycobacterium tuberculosis (Mtb) with MICs of 7.6 μg/mL. Trifluoperazine (< 14.78 mM) suppresses the activities of the mouse splenic NK cell cytotoxicity and the effector-target cell conjugation in a dose dependent manner. Trifluoperazine suppresses interferon-alpha or interleukin-2 induced augmentation of the cytolytic activity of NK cells. Trifluoperazine inhibits the gene expression of voltage-dependent potassium channel Kv2.1 from human brain (hKv2.1).
In vivo
Trifluoperazine dose dependently decreases avoidance responses and increases response failures in rats where behavior is maintained under a discrete-trial avoidance.
Cell Data
cell lines：pancreatic cancer cell line BxPc3-RFP
Concentrations：
Incubation Time：
Powder Purity:≥99%
| Isomeric SMILES | CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F.Cl.Cl |
|---|---|
| WGK Germany | 3 |
| RTECS | SP1750000 |
| PubChem CID | 66064 |
| Molecular Weight | 480.42 |
| Beilstein | 3820020 |
| Reaxy-Rn | 3820024 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Solubility | Solubility (25°C) In vitro DMSO: 35 mg/mL (201.02 mM); Water: 35 mg/mL (201.02 mM); Ethanol: 35 mg/mL |
|---|---|
| Melt Point(°C) | 243°C |
| 1. Yunfeng Ma, Longxia Li, Liufang Mo, Xiaochen Wang, Chenyue Liu, Yijun Wu, Chaoqun Liu. (2023) Preparation and anti-tumor effects of mesoporous silica nanoparticles loaded with trifluoperazine. Journal of Materials Chemistry B, 11 (43): (10395-10403). [PMID:37876312] [10.1039/D3TB01472J] |
| 2. Qiang Hou, Yali Wang, Jian Hu, Jianxiong Zhang, Caihua Zhang, Wang Song, Xuesong Wang, Baiqin Zheng, Xin Zhou. (2024) Simultaneous determination of phenothiazine drugs and their metabolites residues in animal derived foods by high performance liquid chromatography tandem mass spectrometry. FOOD CONTROL, [PMID:] [10.1016/j.foodcont.2024.110799] |
