1,2-Dioleoyl-3-trimethylammonium-propane, Chloride (DOTAP Chloride) - Moligand™, ≥99% , CAS No.132172-61-3

CAS: 132172-61-3 Cat. No.: D351073 Molecular Weight: 698.54

GRADE & PURITY Moligand™, ≥99%

Synonyms

DOTAP | Dotap chloride | (+/-)-Dotap chloride | DOTAP (chloride) | Dotap chloride, (+/-)- | 1,2-Dioleoyl-3-trimethylammonium-propane, Chloride | 1-Propanaminium, N,N,N-trimethyl-2,3-bis[[(9Z)-1-oxo-9-octadecenyl]oxy]-, chloride (1:1)

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

1,2-Dioleoyl-3-trimethylammonium-propane, Chloride is a a cationic lipid used for the transfecting of negatively charged molecules into eurkaryotic cells.

Specifications

Synonyms

DOTAP | Dotap chloride | (+/-)-Dotap chloride | DOTAP (chloride) | Dotap chloride, (+/-)- | 1, 2-Dioleoyl-3-trimethylammonium-propane, Chloride | 1-Propanaminium, N, N, N-trimethyl-2, 3-bis[[(9Z)-1-oxo-9-octadecenyl]oxy]-, chloride (1:1)

Specifications & Purity

Moligand™, ≥99%

Biochemical and Physiological Mechanisms

1, 2-Dioleyloxy-3-(trimethylammonium)propane (DOTAP) chloride can be used to prepare liposomes without the use of cophospholipids. DOTAP chloride is soluble in dimethyl sulfoxide (DMSO) and ethanol, thereby clarifying its role as a transfection reagent.

Storage

Protected from light, Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CCCCCCCCC=CCCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC.[Cl-]
• IUPAC Name: 2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl-trimethylazanium;chloride
• InChIKey: KSXTUUUQYQYKCR-LQDDAWAPSA-M
• INCHI: 1S/C42H80NO4.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h20-23,40H,6-19,24-39H2,1-5H3;1H/q+1;/p-1/b22-20-,23-21-
• Isomeric SMILES: CCCCCCCC/C=C\CCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC.[Cl-]
• Molecular Weight: 698.54
• Reaxy-Rn: 22197383
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22197383&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Class Fatty Acyls
      • Subclass Fatty acid esters

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Class: Fatty Acyls
• Subclass: Fatty acid esters
• Intermediate Tree Nodes: Not available
• Direct Parent: Fatty acid esters
• Alternative Parents: Dicarboxylic acids and derivatives Tetraalkylammonium salts Carboxylic acid esters Organic oxides Organic chloride salts Hydrocarbon derivatives Carbonyl compounds Amines Organic cations
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Fatty acid ester - Dicarboxylic acid or derivatives - Quaternary ammonium salt - Tetraalkylammonium salt - Carboxylic acid ester - Carboxylic acid derivative - Organic chloride salt - Organic salt - Organic oxide - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Amine - Hydrocarbon derivative - Organic cation - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as fatty acid esters. These are carboxylic ester derivatives of a fatty acid.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

Got2 Aspartate aminotransferase mitochondrial (49 Activities)

Discover Target: Got2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in Chloroform and Dichloromethane
• Sensitivity: Moisture sensitive.；Heat sensitive; Light sensitive
• Molecular Weight: 698.500 g/mol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 37
• Exact Mass: 697.578 Da
• Monoisotopic Mass: 697.578 Da
• Topological Polar Surface Area: 52.600 Ų
• Heavy Atom Count: 48
• Formal Charge: 0
• Complexity: 754.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 2
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 2
• Covalently-Bonded Unit Count: 2

XLogP3

References

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