1,4-Piperazinediethanesulfonic acid disodium salt (PIPES 2Na) - ≥98% , CAS No.76836-02-7

CAS: 76836-02-7 Cat. No.: P113025 Molecular Weight: 346.33 Beilstein Registry Number: 9453872 EC Number: 278-562-3

GRADE & PURITY ≥98%

Synonyms

Disodium 2,2'-(Piperazine-1,4-diyl)diethanesulfonate | PIPES 2Na | Disodium Piperazine-1,4-bis(2-ethanesulfonate) | Piperazine-1,4-bis(2-ethanesulfonic acid) disodium salt | PIPES disodium salt

Storage

Room temperature

Shipped In

Normal

Overview

PIPES [piperazine-N,N′-bis(2-ethanesulfonic acid)] is frequently used as a buffering agent in biochemistry; it is an ethanesulfonic acid buffer . in the 1960s. PIPES has a pKa near the physiological pH which makes it useful in cell culture work. It has been documented that PIPES disodium salt may help prevent lipid loss when buffering glutaraldehyde-fixed histological samples.

a buffering agent used in biological applications

Specifications

Synonyms

Disodium 2, 2'-(Piperazine-1, 4-diyl)diethanesulfonate | PIPES 2Na | Disodium Piperazine-1, 4-bis(2-ethanesulfonate) | Piperazine-1, 4-bis(2-ethanesulfonic acid) disodium salt | PIPES disodium salt

Specifications & Purity

≥98%

Storage

Room temperature

Shipped In

Normal

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 488188479
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488188479
• Canonical Smiles: C1CN(CCN1CCS(=O)(=O)[O-])CCS(=O)(=O)[O-].[Na+].[Na+]
• IUPAC Name: disodium;2-[4-(2-sulfonatoethyl)piperazin-1-yl]ethanesulfonate
• InChIKey: GMHSTJRPSVFLMT-UHFFFAOYSA-L
• INCHI: 1S/C8H18N2O6S2.2Na/c11-17(12,13)7-5-9-1-2-10(4-3-9)6-8-18(14,15)16;;/h1-8H2,(H,11,12,13)(H,14,15,16);;/q;2*+1/p-2
• Isomeric SMILES: C1CN(CCN1CCS(=O)(=O)[O-])CCS(=O)(=O)[O-].[Na+].[Na+]
• WGK Germany: 3
• Molecular Weight: 346.33
• Beilstein: 9453872
• Reaxy-Rn: 9453872
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9453872&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Diazinanes
      • Subclass Piperazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Diazinanes
• Subclass: Piperazines
• Intermediate Tree Nodes: Not available
• Direct Parent: N-alkylpiperazines
• Alternative Parents: Sulfonyls Organosulfonic acids Alkanesulfonic acids Trialkylamines Azacyclic compounds Organopnictogen compounds Organic zwitterions Organic sodium salts Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: N-alkylpiperazine - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Organosulfonic acid - Sulfonyl - Alkanesulfonic acid - Tertiary aliphatic amine - Tertiary amine - Organic alkali metal salt - Azacycle - Organic sodium salt - Organic salt - Organic zwitterion - Organic nitrogen compound - Organosulfur compound - Organonitrogen compound - Amine - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Aliphatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as n-alkylpiperazines. These are organic compounds containing a piperazine ring where the nitrogen ring atom carries an alkyl group.
• External Descriptors: organic sodium salt

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Soluble in water (25 gm plus 50 ml of water).
• Molecular Weight: 346.300 g/mol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 4
• Exact Mass: 346.025 Da
• Monoisotopic Mass: 346.025 Da
• Topological Polar Surface Area: 138.000 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 370.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

References

1. Chenglong Yu, Yuxi Lu, Yanting Zhang, Ao Qian, Peng Zhang, Man Tong, Songhu Yuan.  (2022)  Significant Contribution of Solid Organic Matter for Hydroxyl Radical Production during Oxygenation.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,      [PMID:35938447] [10.1021/acs.est.2c02766]

2. Zhenchen Wan, Yuxuan Tan, Yunsong Zheng, Xiuli Li, Songhu Yuan.  (2025)  Tracing chemical and biological O2 consumption in the subsurface by 18O isotope enrichment factors.  APPLIED GEOCHEMISTRY,      [PMID:] [10.1016/j.apgeochem.2025.106647]