2,3,5,6-Tetramethylpyrazine - ≥98% , CAS No.1124-11-4

CAS: 1124-11-4 Cat. No.: T111263 Molecular Weight: 136.19 Beilstein Registry Number: 113100 EC Number: 214-391-2 PubChem CID: 14296
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Synonyms
DTXCID4027070 | HMS3371J08 | CAS-1124-11-4 | CHUANXIONGQIN | F11202 | Q11319317 | NCGC00247063-01 | NSC 36080 | Z1741976694 | Opera_ID_849 | STL163591 | 2,5,6-Tetramethylpyrazine | Tetrapyrazine | chuanxingzine | EINECS 214-391-2 | EN300-113945 | SMR00005
Storage
Room temperature
Shipped In
Normal
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
5g
T111263-5g
3
$9.90
25g
T111263-25g
3
$14.90
100g
T111263-100g
3
$39.90
500g
T111263-500g
3
$133.90
Enter a quantity for the sizes you want to add.
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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Room temperature Ships Normal Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 25 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

2,3,5,6-Tetramethylpyrazine is a flavor ingredient in tobacco that has bee used in the treatment of several disorders such as asthma, heart failure, rhinitis and urinary incontinence.
Usually used in research and treatment of multiple disorders.

Specifications

Synonyms
DTXCID4027070 | HMS3371J08 | CAS-1124-11-4 | CHUANXIONGQIN | F11202 | Q11319317 | NCGC00247063-01 | NSC 36080 | Z1741976694 | Opera_ID_849 | STL163591 | 2, 5, 6-Tetramethylpyrazine | Tetrapyrazine | chuanxingzine | EINECS 214-391-2 | EN300-113945 | SMR00005
Specifications & Purity
≥98%
Storage
Room temperature
Shipped In
Normal
Purity
≥98%
Names and Identifiers
Pubchem Sid488181969
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488181969
Canonical SmilesCC1=C(N=C(C(=N1)C)C)C
IUPAC Name2,3,5,6-tetramethylpyrazine
InChIKeyFINHMKGKINIASC-UHFFFAOYSA-N
INCHI1S/C8H12N2/c1-5-6(2)10-8(4)7(3)9-5/h1-4H3
Isomeric SMILES CC1=C(N=C(C(=N1)C)C)C
WGK Germany 3
RTECS UQ3905000
PubChem CID 14296
Molecular Weight 136.19
Beilstein 113100
Reaxy-Rn 113100

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassDiazines
SubclassPyrazines
Intermediate Tree Nodes Not available
Direct ParentPyrazines
Alternative Parents Heteroaromatic compounds  Azacyclic compounds  Organopnictogen compounds  Organonitrogen compounds  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents Pyrazine - Heteroaromatic compound - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteromonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as pyrazines. These are compounds containing a pyrazine ring, which is a six-member aromatic heterocycle, that consists of two nitrogen atoms (at positions 1 and 4) and four carbon atoms.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ECV-304 (406 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
K562 (73714 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SH-SY5Y (11521 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U-87 MG (3946 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bel-7402 (4577 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HUVEC (11049 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCB11 Tchem Bile salt export pump (2311 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-12 (7051 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TRXR Thioredoxin reductase (20 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Thoracic aorta (838 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

18 results found

Lot NumberCertificate TypeDateItem
A2605602Certificate of AnalysisDec 26, 2025 T111263
A2605603Certificate of AnalysisDec 26, 2025 T111263
A2605609Certificate of AnalysisDec 26, 2025 T111263
A2605598Certificate of AnalysisDec 26, 2025 T111263
G2528372Certificate of AnalysisJul 16, 2025 T111263
G2528371Certificate of AnalysisJul 16, 2025 T111263
G2528369Certificate of AnalysisJul 16, 2025 T111263
F2303643Certificate of AnalysisMay 20, 2023 T111263
F2303766Certificate of AnalysisMay 20, 2023 T111263
F2303751Certificate of AnalysisMay 20, 2023 T111263
F2303736Certificate of AnalysisMay 20, 2023 T111263
F2303663Certificate of AnalysisMay 20, 2023 T111263
C2519386Certificate of AnalysisMay 20, 2023 T111263
B2315587Certificate of AnalysisFeb 21, 2023 T111263
B2315585Certificate of AnalysisFeb 20, 2023 T111263
B2315487Certificate of AnalysisFeb 20, 2023 T111263
E2306038Certificate of AnalysisDec 02, 2021 T111263
K2218119Certificate of AnalysisDec 02, 2021 T111263

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Chemical and Physical Properties
SolubilitySolubility in Methanol within almost transparency;Soluble in water (4 g/L at 20°C).
Boil Point(°C)190°C
Melt Point(°C)82-86°C
Molecular Weight136.190 g/mol
XLogP31.300
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass136.1 Da
Monoisotopic Mass136.1 Da
Topological Polar Surface Area25.800 Ų
Heavy Atom Count10
Formal Charge0
Complexity87.800
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Yue Luo, Siyue Zhu, Jie Peng, Heping Cui, Qingrong Huang, Baojun Xu, Chi-Tang Ho.  (2023)  Feasibility Study of Amadori Rearrangement Products of Glycine, Diglycine, Triglycine, and Glucose as Potential Food Additives for Production, Stability, and Flavor Formation.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:38109376] [10.1021/acs.jafc.3c06250]
2. Hong Yang, Jing Wang, Wenming Cao.  (2023)  Improved liquid-liquid extraction followed by HPLC-UV for accurate and eco-friendly determination of tetramethylpyrazine in vinegar products.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,      [PMID:37716345] [10.1016/j.jchromb.2023.123869]
3. Li Chen, Qingshun Nian, Digen Ruan, Jiajia Fan, Yecheng Li, Shunqiang Chen, Lijiang Tan, Xuan Luo, Zhuangzhuang Cui, Yifeng Cheng, Changhao Li, Xiaodi Ren.  (2022)  High-safety and high-efficiency electrolyte design for 4.6 V-class lithium-ion batteries with a non-solvating flame-retardant.  Chemical Science,  14  (5): (1184-1193).  [PMID:36756331] [10.1039/D2SC05723A]
4. Tong Zhou, Xue Xia, Heping Cui, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2022)  Competitive Formation of 2,3-Butanedione and Pyrazines through Intervention of Added Cysteine during Thermal Processing of Alanine-Xylose Amadori Compounds.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:36444759] [10.1021/acs.jafc.2c07026]
5. Shibin Deng, Yun Zhai, Heping Cui, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2022)  Mechanism of Pyrazine Formation Intervened by Oxidized Methionines during Thermal Degradation of the Methionine–Glucose Amadori Compound.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:36342227] [10.1021/acs.jafc.2c06458]
6. Ren Yanling, Wang Tao, Jiang Yingjie, Chen Pengchao, Tang Jian, Wang Juan, Jin Daochao, Guo Jianjun.  (2022)  Research of Synergistic Substances on Tobacco Beetle [Lasioderma serricorne (Fabricius) (Coleoptera: Anobiidae)] Adults Attractants.  Frontiers in Chemistry,      [PMID:35755262] [10.3389/fchem.2022.921113]
7. Jian-Li Qiu, Guo-Feng Zhang, Yu-Na Chai, Xiao-Yan Han, Hai-Tao Zheng, Xiang-Feng Li, Fei Duan, Ling-Yan Chen.  (2022)  Ligustrazine Attenuates Liver Fibrosis by Targeting miR-145 Mediated Transforming Growth Factor-β/Smad Signaling in an Animal Model of Biliary Atresia.  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,  381  (3): (257-265).  [PMID:35398813] [10.1124/jpet.121.001020]
8. Tao Tian, Guo-Ying Chen, Hao Zhang, Feng-Qing Yang.  (2021)  Personal Glucose Meter for α-Glucosidase Inhibitor Screening Based on the Hydrolysis of Maltose.  MOLECULES,  26  (15): (4638).  [PMID:34361791] [10.3390/molecules26154638]
9. Hanjun Zhang, Furong Tao, Yuezhi Cui, Hongtao Wu.  (2020)  Super-quenching: Multiple migration channels of excitons cause “area quenching”.  MATERIALS CHEMISTRY AND PHYSICS,      [PMID:] [10.1016/j.matchemphys.2020.122657]
10. Zhou Wei, Chen Ziyi, Zhang Guohao, Liu Zhigang.  (2019)  Systems pharmacology-based approach for dissecting the mechanisms of pyrazine components in Maotai liquor.  BIOSCIENCE REPORTS,  39  (10):   [PMID:31511433] [10.1042/BSR20191864]
11. Hui Wang, Wenxi Zhang, Yatao Cheng, Xinyu Zhang, Nannan Xue, Gaorong Wu, Meng Chen, Kang Fang, Wenbo Guo, Fei Zhou, Herong Cui, Tao Ma, Penglong Wang, Haimin Lei.  (2018)  Design, Synthesis and Biological Evaluation of Ligustrazine-Flavonoid Derivatives as Potential Anti-Tumor Agents.  MOLECULES,  23  (9): (2187).  [PMID:30200208] [10.3390/molecules23092187]
12. Chen Long, Liu Tianjun, Wang Qiangsong, Liu Juan.  (2017)  Anti-inflammatory effect of combined tetramethylpyrazine, resveratrol and curcumin in vivo.  BMC Complementary and Alternative Medicine,  17  (1): (1-10).  [PMID:28449676] [10.1186/s12906-017-1739-7]
13. Qing Wang, Yao Long, Lin Yao, Li Xu, Zhi-Guo Shi, Lanying Xu.  (2015)  Preparation, characterization and application of a reversed phase liquid chromatography/hydrophilic interaction chromatography mixed-mode C18-DTT stationary phase.  TALANTA,      [PMID:26695288] [10.1016/j.talanta.2015.09.009]
14. Zhang Xuemei, Wei Junhua, Ma Pengkai, Mu Hongjie, Wang Aiping, Zhang Leiming, Wu Zimei, Sun Kaoxiang.  (2014)  Preparation and evaluation of a novel biodegradable long-acting intravitreal implant containing ligustrazine for the treatment of proliferative vitreoretinopathy.  JOURNAL OF PHARMACY AND PHARMACOLOGY,  67  (2): (160-169).  [PMID:25557298] [10.1111/jphp.12327]
15. Qibo Tan, Yongjun Wu, Cen Li, Jing Jin, Lincheng Zhang, Shuoqiu Tong, Zhaofeng Chen, Li Ran, Lu Huang, Zeyan Zuo.  (2024)  Characterization of Key Aroma Compounds of Soy Sauce-like Aroma Produced in Ferment of Soybeans by Bacillus subtilis BJ3-2.  Foods,  13  (17): (2731).  [PMID:39272497] [10.3390/foods13172731]
16. Yuchen Bai, Ningke You, Hongyu Tian, Xuebing Zhao.  (2025)  Characterization of Key Odorants in Hemp Seed Oil Extracted from the Hemp Seeds Roasted Under Various Conditions.  Processes,  13  (2): (530).  [PMID:] [10.3390/pr13020530]
17. Zhe Cai, Qinbo Jiang, Ruihao Zhang, Yifang Ma, Kaini Chen, Shijie Zheng, Peng Li, Cheng Zeng, Hui Zhang.  (2024)  Comparison of extraction and refinement techniques for volatile compound analysis in camellia oil.  FOOD CHEMISTRY,      [PMID:39709918] [10.1016/j.foodchem.2024.142501]
18. Fangfang Shang, Hengdao Quan, Xiaoxun Ma.  (2024)  Enhancing the interface stability of Li/NCM622 batteries by adding 3-trifluoromethyl pyrazole.  Surfaces and Interfaces,      [PMID:] [10.1016/j.surfin.2024.105249]
19. Yating Rui, Jianfeng Wu, Qunyong Tang, Juan Pu, Wanpeng Wang, Shou-Nian Ding.  (2025)  Molecularly imprinted electrochemical sensor to sensitively detect tetramethylpyrazine in Baijiu.  ANALYST,  150  (5): (887-893).  [PMID:39874135] [10.1039/D4AN01559B]
20. Mingjing Yin, Jicheng Yuan, Lina Yu, Xinying Ma, Kun Long, Mingyong Chao.  (2024)  Poly(L-lysine) modified glassy carbon electrode for sensitive electrochemical measurement of 2,3,5,6-tetramethylpyrazine.  International Journal of Electrochemical Science,      [PMID:] [10.1016/j.ijoes.2024.100500]
21. Li Ran, Yongjun Wu, Jing Jin, Lincheng Zhang, Cen Li, Shuoqiu Tong, Feng Wen, ZhongHui Mou.  (2025)  l-Threonine Catabolism Driven Flavor Formation: A Key Pathway for Soy Sauce-Like Aroma in Bacillus subtilis Fermentation.  JOURNAL OF FOOD SCIENCE,  90  (8): (e70466).  [PMID:40754703] [10.1111/1750-3841.70466]
22. Ping Tang, Qingliang Li, Changwen Li, Dongguang Xiao, Xiaodan Wang, Xuewu Guo.  (2025)  Analysis and formation mechanism of Key aroma compounds with ammonia-like off-flavors in Jiang-flavored high-temperature daqu: Substances composition and main microorganisms.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2025.107656]
23. Yisong Liu, Chunfeng Liu, Xin Xu, Chengtuo Niu, Jinjing Wang, Feiyun Zheng, Qi Li.  (2022)  Development of a Rapid and Sensitive Fluorescence Sensing Method for the Detection of Acetaldehyde in Alcoholic Beverages.  Foods,  11  (21): (3450).  [PMID:36360062] [10.3390/foods11213450]
24. Qing Wang, Yao Long, Lin Yao, Mao Ye, Li Xu.  (2017)  C18-COOH Silica: Preparation, Characterisation and Its Application in Purification of Quaternary Ammonium Alkaloids from Coptis chinensis.  PHYTOCHEMICAL ANALYSIS,  28  (4): (332-343).  [PMID:28198057] [10.1002/pca.2680]
25. Nian Cao, Yubo Yang, Xiaoling Xiong, Bohan Zhang, Ping Xiang, Fan Yang.  (2026)  Dynamic sensory mapping: how sip volume shapes sensory perception and drinking comfort of Jiangxiangxing Baijiu.  INTERNATIONAL JOURNAL OF FOOD PROPERTIES,      [PMID:] [10.1080/10942912.2026.2618833]
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