Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 23 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
2-Hydroxy-4-methoxybenzophenone (benzophenone-3) is commonly employed as broad-band UV-filter in sunscreen cosmetic products. It protects skin from the deleterious effects of the sun. It is one of the sunscreen constituent and its trace determination in water samples by solid-phase microextraction (SPME) and gas chromatography with flame ionization and mass spectrometric detection has been reported.
| ALogP | 3.6 |
|---|
| Canonical Smiles | COC1=CC(=C(C=C1)C(=O)C2=CC=CC=C2)O |
|---|---|
| IUPAC Name | (2-hydroxy-4-methoxyphenyl)-phenylmethanone |
| InChIKey | DXGLGDHPHMLXJC-UHFFFAOYSA-N |
| INCHI | 1S/C14H12O3/c1-17-11-7-8-12(13(15)9-11)14(16)10-5-3-2-4-6-10/h2-9,15H,1H3 |
| Isomeric SMILES | COC1=CC(=C(C=C1)C(=O)C2=CC=CC=C2)O |
| WGK Germany | 2 |
| RTECS | DJ1575000 |
| Molecular Weight | 228.24 |
| Beilstein | 1913145 |
| Reaxy-Rn | 1913145 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1913145&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Benzene and substituted derivatives |
| Subclass | Benzophenones |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Benzophenones |
| Alternative Parents | Diphenylmethanes Aryl-phenylketones Methoxyphenols Phenoxy compounds Methoxybenzenes Benzoyl derivatives Anisoles Alkyl aryl ethers 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Vinylogous acids Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Benzophenone - Diphenylmethane - Aryl-phenylketone - Methoxyphenol - Anisole - Phenoxy compound - Methoxybenzene - Benzoyl - Aryl ketone - Phenol ether - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Alkyl aryl ether - Vinylogous acid - Ketone - Ether - Organooxygen compound - Organic oxygen compound - Hydrocarbon derivative - Organic oxide - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as benzophenones. These are organic compounds containing a ketone attached to two phenyl groups. |
| External Descriptors | monomethoxybenzene - hydroxybenzophenone |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Flash Point(°F) | 212 °F |
|---|---|
| Flash Point(°C) | 100 °C |
| Boil Point(°C) | 150-160°C |
| Melt Point(°C) | 62-64°C |
| Molecular Weight | 228.240 g/mol |
| XLogP3 | 3.600 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 3 |
| Exact Mass | 228.079 Da |
| Monoisotopic Mass | 228.079 Da |
| Topological Polar Surface Area | 46.500 Ų |
| Heavy Atom Count | 17 |
| Formal Charge | 0 |
| Complexity | 258.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Lianxu Wang, Zhen Lei, Sining Yun, Xiaohuan Yang, Rong Chen. (2023) Quantitative structure-biotransformation relationships of organic micropollutants in aerobic and anaerobic wastewater treatments. SCIENCE OF THE TOTAL ENVIRONMENT, [PMID:38072270] [10.1016/j.scitotenv.2023.169170] |
| 2. Tongchen Zhang, Huan Wu, Matin Naghizadeh, Qian Zheng, Sheying Dong. (2023) Magnetic Porous Polymer with −OH Groups as Sorbent for Excellent Extraction and Removal of Personal Care Products from Water. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, [PMID:] [10.1021/acs.iecr.3c00453] |
| 3. Caimei Lu, Rongrong Song, Junhui Wang, Kun Liu, Tian Fu, Rui Tang, Luying Jiang, Zhangfa Tong, Hanbing Zhang. (2023) New insights into cupric ion-mediated ligand-to-metal charge transfer between TiO2 with peroxydisulfate under visible light for bolstering benzophenone-3 degradation. SEPARATION AND PURIFICATION TECHNOLOGY, [PMID:] [10.1016/j.seppur.2023.123168] |
| 4. Sun Min, Wang Xiuqin, Ding Yali, Feng Juanjuan. (2022) Titania hybridized melamine–formaldehyde aerogel for online in-tube solid-phase microextraction of polycyclic aromatic hydrocarbons prior to HPLC–DAD. MICROCHIMICA ACTA, 189 (12): (1-10). [PMID:36416994] [10.1007/s00604-022-05572-3] |
| 5. Wang Xueting, Chang Rui, Ji Zhongyin, Song Jinying, Yuan Fei, Zhang Shijuan. (2022) Improved Extraction and Detection Method for Bisphenols Using Stable Isotope Labeling Technique. Food Analytical Methods, 16 (2): (281-292). [PMID:] [10.1007/s12161-022-02413-0] |
| 6. Yaping Gan, Yan Zhu. (2022) Multi-Residue Analysis of Chemical Additives in Edible Vegetable Oils Using QuEChERS Extraction Method Followed by Supercritical Fluid Chromatography. MOLECULES, 27 (5): (1681). [PMID:35268782] [10.3390/molecules27051681] |
| 7. Yu Sun, Guanghua Lu, Peng Zhang, Xin Ling, Ranran Zhou, Zhenhua Yan, Jianchao Liu. (2021) Influence of organic colloids on the uptake, accumulation and effects of benzophenone-3 in aquatic animals. Environmental Science-Nano, 8 (12): (3590-3602). [PMID:] [10.1039/D1EN00639H] |
| 8. Huazi Wang, Qinqin Xu, Jinglong Jiao, Hai Wu. (2021) A solidified floating organic drop-dispersive liquid–liquid microextraction based on in situ formed fatty acid-based deep eutectic solvents for the extraction of benzophenone-UV filters from water samples. NEW JOURNAL OF CHEMISTRY, 45 (31): (14082-14090). [PMID:] [10.1039/D1NJ01393A] |
| 9. Jianmin Chen, Mengnan Ran, Meixia Wang, Xinying Liu, Siwan Liu, Zhipeng Ruan, Nan Jin. (2021) Evaluation of antityrosinase activity and mechanism, antioxidation, and UV filter properties of theaflavin. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 69 (3): (951-962). [PMID:33878231] [10.1002/bab.2166] |
| 10. Ge Dandan, Zhong Guoqiong, Zhou Xiaojuan, Dai Enrui, Wang Ying. (2019) Elevated temperature-assisted surfactant-enhanced emulsification microextraction based on solidification of a floating organic drop for the determination of UV filters in water samples by high-performance liquid chromatography coupled to a diode array detector. Journal of the Iranian Chemical Society, 17 (2): (499-506). [PMID:] [10.1007/s13738-019-01785-1] |
| 11. Wenqing Li, Rong Wang, Zilin Chen. (2019) Metal-organic framework-1210(zirconium/cuprum) modified magnetic nanoparticles for solid phase extraction of benzophenones in soil samples. JOURNAL OF CHROMATOGRAPHY A, [PMID:31378523] [10.1016/j.chroma.2019.460403] |
| 12. Cheng Jie, Kong Xiaojian, Liu Shucheng, Che Dandan, Sun Zhiwei, Li Guoliang, Ping Meiling, Tang Jingpu, You Jinmao. (2018) Determination of Ultraviolet Filters in Domestic Wastewater by LC–MS Coupled with Polydopamine-Based Magnetic Solid-Phase Extraction and Isotope-Coded Derivatization. CHROMATOGRAPHIA, 81 (12): (1673-1684). [PMID:] [10.1007/s10337-018-3650-x] |
| 13. Du Jingjing, Qv Mingxiang, Li Ke, Yin Xiaoyun, Meng Fanxiao, Yang Jingchao, Ma Chuang. (2018) Impacts of benzophenone-type UV filters on cladoceran Daphnia carinata. LIMNOLOGY, 20 (2): (173-179). [PMID:] [10.1007/s10201-018-0563-1] |
| 14. Dandan Ge, Yi Zhang, Yixiu Dai, Shumin Yang. (2017) Air-assisted dispersive liquid–liquid microextraction based on a new hydrophobic deep eutectic solvent for the preconcentration of benzophenone-type UV filters from aqueous samples. JOURNAL OF SEPARATION SCIENCE, 41 (7): (1635-1643). [PMID:29282887] [10.1002/jssc.201701282] |
| 15. Huiqi Wang, Zheng Li, Wei Feng, Qiong Jia. (2017) Polymer monolith containing an embedded covalent organic framework for the effective enrichment of benzophenones. NEW JOURNAL OF CHEMISTRY, 41 (21): (13043-13050). [PMID:] [10.1039/C7NJ02512B] |
| 16. Teng Ma, Zheng Li, Qian Niu, Yuanyuan Li, Weihong Zhou. (2015) Double dispersant-assisted ionic liquid dispersive liquid–liquid microextraction coupled with capillary electrophoresis for the determination of benzophenone-type ultraviolet filters in sunscreen cosmetic product. ELECTROPHORESIS, 36 (20): (2530-2537). [PMID:26105533] [10.1002/elps.201500004] |
| 17. Ning Li, Quanfei Zhu, Yang Yang, Jianlin Huang, Xueping Dang, Huaixia Chen. (2014) A novel dispersive solid-phase extraction method using metal-organic framework MIL-101 as the adsorbent for the analysis of benzophenones in toner. TALANTA, [PMID:25476369] [10.1016/j.talanta.2014.10.038] |
| 18. Xiaojia Chen, Jingzhi Yao, Yu Ma, Yuanyuan Fang, Wenxin Wang, Xiaojun Deng, Ling Tan, Yi-Jun Fan, Mingliang Fang. (2024) Rapid Screening of Chemicals with Placental Transfer Risk Using Interpretable Machine Learning. Environmental Science & Technology Letters, [PMID:] [10.1021/acs.estlett.4c00413] |
| 19. Fangfang Chen, Jiaming Wang, Wei Xu, Zhuangzhuang Ren, Guan Peng, Tao Huang, Fei Zhao. (2024) Self-assembly aggregation-induced emission from Eu (III) complexes with o-hydroxy-benzophenone ligands. JOURNAL OF ALLOYS AND COMPOUNDS, [PMID:] [10.1016/j.jallcom.2024.177421] |
| 20. Huiyu He, Rui Wang, Rongbin Nie, Nan Dong. (2025) An environmentally friendly cucurbit[7]uril-mediated magnetic-assisted matrix solid-phase dispersion extraction combined with HPLC-MS/MS for multiple analysis of pharmaceuticals and personal care products in aquatic organisms. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2025.115146] |
| 21. Yu Yeli, Zhang Yong, Yang Xiaogang, Liu Hongyi, Shao Lan, Zhang Xiumei, Yao Juming. (2015) Biodegradation process and yellowing mechanism of an ecofriendly superabsorbent based on cellulose from flax yarn wastes. CELLULOSE, 22 (1): (329-338). [PMID:] [10.1007/s10570-014-0531-9] |
| 22. Yanhong Song, Yueze Hong, Jun Deng, Haoyu Zou, Jianyu Xin, Fanjun Zhang, Qing Jiang, Yunbing Wang. (2025) Foldable and Hydration-Rigidified Acrylate Polymer for a Highly Stable and UV-Filtering Phakic Intraocular Lens. BIOMACROMOLECULES, [PMID:41042225] [10.1021/acs.biomac.5c01335] |
| 23. Yangcheng Liu, Baoli Xu, Shengxue Wang, Qilin Liu, Zheng Xiang, Wanwei Jiang, Yang Wang. (2025) Constructing rice grain–dotted accordion-like TB–COF@NH₂–MXene to promote the simultaneous efficient elimination and sensitive detection of benzophenones. FOOD CHEMISTRY, [PMID:41475205] [10.1016/j.foodchem.2025.147715] |