4-(3-Chloropropyl)morpholine - ≥98%(GC) , CAS No.7357-67-7

CAS: 7357-67-7 Cat. No.: C124693 Molecular Weight: 163.65 EC Number: 461-510-0

GRADE & PURITY ≥98%(GC)

Synonyms

RU-3366 | UNII-82BVM8E6TN | 1-Chloro-3-morpholinopropane | A9483 | Morpholine, 4-(3-chloropropyl)- | AS-7029 | NSC28831 | NSC-28831 | BCP02629 | MFCD00039714 | chloropropylmorpholine | RU-2267 | 1-CHLORO-3-(MORPHOLIN-4-YL)PROPANE | 3-morpholino-1-chloropr

Storage

Store at 2-8°C,Argon charged

Shipped In

Wet ice

Overview

4-(3-Chloropropyl)morpholine is an intermediate of Gefitinib.

Specifications

Synonyms

RU-3366 | UNII-82BVM8E6TN | 1-Chloro-3-morpholinopropane | A9483 | Morpholine, 4-(3-chloropropyl)- | AS-7029 | NSC28831 | NSC-28831 | BCP02629 | MFCD00039714 | chloropropylmorpholine | RU-2267 | 1-CHLORO-3-(MORPHOLIN-4-YL)PROPANE | 3-morpholino-1-chloropr

Specifications & Purity

≥98%(GC)

Storage

Store at 2-8°C, Argon charged

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%(GC)

Names and Identifiers

• Pubchem Sid: 508809239
• Canonical Smiles: C1COCCN1CCCCl
• IUPAC Name: 4-(3-chloropropyl)morpholine
• InChIKey: PIAZYBLGBSMNLX-UHFFFAOYSA-N
• INCHI: 1S/C7H14ClNO/c8-2-1-3-9-4-6-10-7-5-9/h1-7H2
• Isomeric SMILES: C1COCCN1CCCCl
• RTECS: QE0488000
• Molecular Weight: 163.65
• Reaxy-Rn: 105107
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=105107&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Oxazinanes
      • Subclass Morpholines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Oxazinanes
• Subclass: Morpholines
• Intermediate Tree Nodes: Not available
• Direct Parent: Morpholines
• Alternative Parents: Trialkylamines Oxacyclic compounds Dialkyl ethers Azacyclic compounds Organopnictogen compounds Organochlorides Hydrocarbon derivatives Alkyl chlorides
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Morpholine - Tertiary amine - Tertiary aliphatic amine - Dialkyl ether - Ether - Azacycle - Oxacycle - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Organic nitrogen compound - Alkyl chloride - Organopnictogen compound - Alkyl halide - Amine - Hydrocarbon derivative - Aliphatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as morpholines. These are organic compounds containing a morpholine moiety, which consists of a six-member aliphatic saturated ring with the formula C4H9NO, where the oxygen and nitrogen atoms lie at positions 1 and 4, respectively.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Soluble in Chloroform.
• Sensitivity: Air & Heat Sensitive
• Refractive Index: 1.47
• Flash Point(°C): 91 °C
• Boil Point(°C): 115°C/25mmHg
• Molecular Weight: 163.640 g/mol
• XLogP3: 0.800
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 163.076 Da
• Monoisotopic Mass: 163.076 Da
• Topological Polar Surface Area: 12.500 Ų
• Heavy Atom Count: 10
• Formal Charge: 0
• Complexity: 83.700
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Zhanguo Sun, Bin Liu, Huijun Liu.  (2025)  Construction of Triphenylamine-Based Aggregation-Induced Emission Luminogens for Lysosomes Imaging and Its Application in the Photodynamic Therapy of Cancer Cells.  MOLECULES,  30  (11): (2272).  [PMID:40509160] [10.3390/molecules30112272]