4-Ethoxyaniline - ≥98% , CAS No.156-43-4

CAS: 156-43-4 Cat. No.: E108459 Molecular Weight: 137.18 Beilstein Registry Number: 606666 EC Number: 205-855-5
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Synonyms
4-Ethoxybenzenamine | Ethyl p-aminophenol | AMY38132 | E78819 | BRN 0606666 | NCGC00091785-01 | p-aminophenyl ethyl ether | STR01492 | CAS-156-43-4 | EINECS 205-855-5 | CP 5685 | STK397546 | NSC 3116 | Z57127438 | AKOS000100572 | Aniline, p-ethoxy- | BIDD
Storage
Store at 2-8°C,Argon charged
Shipped In
Wet ice,FedEx DG Service
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
25g
E108459-25g
1
$11.90
100g
E108459-100g
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$18.90
500g
E108459-500g
2
$55.90
Enter a quantity for the sizes you want to add.
🧪

Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at 2-8°C,Argon charged Ships Wet ice,FedEx DG Service Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 3 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
4-Ethoxybenzenamine | Ethyl p-aminophenol | AMY38132 | E78819 | BRN 0606666 | NCGC00091785-01 | p-aminophenyl ethyl ether | STR01492 | CAS-156-43-4 | EINECS 205-855-5 | CP 5685 | STK397546 | NSC 3116 | Z57127438 | AKOS000100572 | Aniline, p-ethoxy- | BIDD
Specifications & Purity
≥98%
Storage
Store at 2-8°C, Argon charged
Shipped In
Wet ice, FedEx DG Service
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥98%
Names and Identifiers
Pubchem Sid504751789
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504751789
Canonical SmilesCCOC1=CC=C(C=C1)N
IUPAC Name4-ethoxyaniline
InChIKeyIMPPGHMHELILKG-UHFFFAOYSA-N
INCHI1S/C8H11NO/c1-2-10-8-5-3-7(9)4-6-8/h3-6H,2,9H2,1H3
Isomeric SMILES CCOC1=CC=C(C=C1)N
WGK Germany 1
RTECS SI6465500
UN Number 2311
Packing Group III
Molecular Weight 137.18
Beilstein 606666
Reaxy-Rn 606666
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=606666&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClassPhenol ethers
SubclassAminophenyl ethers
Intermediate Tree Nodes Not available
Direct ParentAminophenyl ethers
Alternative Parents Phenoxy compounds  Aniline and substituted anilines  Alkyl aryl ethers  Primary amines  Organopnictogen compounds  Hydrocarbon derivatives  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents Aminophenyl ether - Phenoxy compound - Aniline or substituted anilines - Alkyl aryl ether - Monocyclic benzene moiety - Ether - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Primary amine - Organooxygen compound - Organonitrogen compound - Amine - Aromatic homomonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as aminophenyl ethers. These are aromatic compounds that contain a phenol ether, which carries an amine group on the benzene ring.
External Descriptors aromatic ether - substituted aniline - primary amino compound
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UGT1A4 Tbio UDP-glucuronosyltransferase 1A4 (288 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lymphoblastoid cell (5959 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GNAS Tbio Guanine nucleotide-binding protein G(s), subunit alpha (103405 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAN Tchem GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 (21853 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Ppard Peroxisome proliferator-activated receptor delta (358 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium tuberculosis (203094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
vpr Aberrant vpr protein (14595 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot NumberCertificate TypeDateItem
E2607135Certificate of AnalysisMay 12, 2026 E108459
D2621108Certificate of AnalysisApr 30, 2026 E108459
I2518062Certificate of AnalysisSep 28, 2025 E108459
K2130384Certificate of AnalysisSep 09, 2025 E108459
K2130385Certificate of AnalysisSep 09, 2025 E108459
K2130386Certificate of AnalysisSep 09, 2025 E108459
C2414526Certificate of AnalysisMar 01, 2024 E108459
C2020134Certificate of AnalysisJan 11, 2024 E108459
C2307094Certificate of AnalysisOct 19, 2021 E108459
F2405103Certificate of AnalysisOct 19, 2021 E108459
L2418114Certificate of AnalysisOct 19, 2021 E108459

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Chemical and Physical Properties
SolubilityNot miscible or difficult to mix in water.
SensitivityHeat & Light & Air sensitive
Refractive Index1.559
Flash Point(°F)284 °F
Flash Point(°C)116 °C
Boil Point(°C)250°C
Melt Point(°C)2-5°C
Molecular Weight137.180 g/mol
XLogP31.200
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass137.084 Da
Monoisotopic Mass137.084 Da
Topological Polar Surface Area35.300 Ų
Heavy Atom Count10
Formal Charge0
Complexity87.300
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Hai-Xia Yu, Xinxin Yu, Siwei Chen, Jingcheng Hao, Lu Xu.  (2023)  A monosurfactant-stabilized dual-responsive and versatile emulsion lubricant.  Journal of Cleaner Production,      [PMID:] [10.1016/j.jclepro.2023.137089]
2. Chi Chen, Yangyuanchen Liu, Ximin He, Hua Li, Yujie Chen, Ying Wei, Yusen Zhao, Yanfei Ma, Zhen Chen, Xu Zheng, Hezhou Liu.  (2021)  Multiresponse Shape-Memory Nanocomposite with a Reversible Cycle for Powerful Artificial Muscles.  CHEMISTRY OF MATERIALS,      [PMID:] [10.1021/acs.chemmater.0c04170]
3. Zhuoqin Li, Minghui Ma, Zhiyin Xiao, Xiujuan Jiang, Xinlei Xu, Hailong Wang, Peter C. Ford, Xiaoming Liu.  (2024)  Increasing the CO-Release Photosensitivity of Mn(I) Carbonyl Complexes Towards Longer Wavelengths by Electronically Tuning Their Schiff Base Ligands.  APPLIED ORGANOMETALLIC CHEMISTRY,  39  (1): (e7959).  [PMID:] [10.1002/aoc.7959]
Solution Calculators
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