4-Hydroxytamoxifen (Afimoxifene) - 10mM in DMSO , CAS No.68392-35-8

CAS: 68392-35-8 Cat. No.: H408276 Molecular Weight: 387.51 EC Number: 627-097-8

GRADE & PURITY 10mM in DMSO

Synonyms

Afimoxifene | Phenol, 4-​[1-​[4-​[2-​(dimethylamino)​ethoxy]​phenyl]​-​2-​phenyl-​1-​buten-​1-​yl]​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

4-Hydroxytamoxifen (Afimoxifene) 4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. It activates
In vitro

4-OHT is a potent activator of ER and has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. It has significant dose and time-dependent direct effects to alter the contractile function of isolated adult rat cardiac myocytes. 4-HT activates on-target modification frequency for intein-Cas9 variants .

In vivo

Cell Data

cell lines：

Concentrations：0, 0.5, 1, 3, 5, and 10 µM

Incubation Time：15-45 min

Powder Purity:≥98%

Specifications

Synonyms

Afimoxifene | Phenol, 4-​[1-​[4-​[2-​(dimethylamino)​ethoxy]​phenyl]​-​2-​phenyl-​1-​buten-​1-​yl]​-

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. It activates on-target modification frequency fo

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

MODULATOR

Names and Identifiers

• Isomeric SMILES: CC/C(=C(\C1=CC=C(C=C1)O)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3
• WGK Germany: 3
• RTECS: SL1210000
• Alternate CAS: 68047-06-3
• Molecular Weight: 387.51
• Reaxy-Rn: 7941290
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7941290&ln=

Associated Targets(Human)

ESR1 Tclin Estrogen receptor (9 Activities)

Discover Target: ESR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)