α(2→3,6,8,9) Neuraminidase from Arthrobacter ureafaciens, CAS No.9001-67-6

CAS: 9001-67-6 Cat. No.: N755087 EC Number: 232-624-6

GRADE & PURITY Proteomics grade, suitable for MALDI-TOF MS

Overview

Neuraminidase is an important deglycosylation enzyme capable of cleaving all non-reducing unbranched N-acetylneuraminic and N-glycolylneuraminic acid residues by hydrolysis of α(2→6), α(2→3), α(2→8), and α(2→9) linkages (affinity in the order given). Branched sialic acids may also be cleaved with the use of high concentrations of enzyme and prolonged incubations. Desialylated glycoproteins may then be further characterized by treatment with various exoglycosidases resulting in partial or complete O-deglycosylation. SDS-PAGE and MALDI-TOF MS are typically utilized in purification, structural analysis, and sequencing process. These techniques also remove heterogeneity and charge from the glycoprotein.

Specifications

Product Name

α(2→3,6,8,9) Neuraminidase from Arthrobacter ureafaciens, CAS No.9001-67-6

Grade

Proteomics grade

Specifications & Purity

Proteomics grade, suitable for MALDI-TOF MS

CAS

9001-67-6

Enzyme Commission Number

3.2.1.18(BRENDA, IUBMB)

Molecule Type

Enzyme

Storage and Shipping

Concentration

suitable for MALDI-TOF MS

Storage

Store at 2-8°C

Shipped In

Wet ice

References

1. Qian Wang, Zichao Peng, Bin Gui, Yongming Li, Lanjie Liao, Zuoyan Zhu, Yaping Wang, Libo He.  (2025)  Sialic acid serves as a functional receptor for grass carp reovirus.  PLoS Pathogens,  21  (9): (e1013481).  [PMID:40911632] [10.1371/journal.ppat.1013481]

2. Yifei Wang, Mengyi Zhang, Yimeng An, Lanshu Li, Hao Wu, Ziqi Cheng, Ling Pan, Chaoying Yang, Weijin Huang, Yansheng Geng, Chenyan Zhao.  (2025)  A Bioluminescent Imaging Mouse Model for Seasonal Influenza Virus Infection Based on a Pseudovirus System.  Viruses-Basel,  17  (5): (686).  [PMID:40431697] [10.3390/v17050686]