Acridine - ≥98% , DNA disrupting agent, CAS No.260-94-6, DNA disrupting agent

CAS: 260-94-6 Cat. No.: A106024 Formula: C₁₃H₉N Molecular Weight: 179.22 Beilstein Registry Number: 120200 EC Number: 205-971-6

GRADE & PURITY ≥98%

Synonyms

10-Azaanthracene|UPCMLD-DP077:001|ACRIDINE|Benzo[b]quinoline|acridine acid|Akridin [Czech]|2,3-Benzoquinoline|ACRIDINE [MI]|Benzoquinolinylidene|2,3,5,6-Dibenzopyridine|9-Azaanthracene|Benzo(b)quinoline|Dibenzo(b,e)pyridine|Coal tar pitch volatiles: acridine|Acridines|Acridine (purified by sublimation)|Akridin|Acrydine|ACRIDINE (1,2,3,4,5,6,7,8,9-D9)|Acridine [UN2713] [Poison]

Storage

Room temperature

Shipped In

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Overview

The fluorescence intensity, fluorescence quantum yield, time of decay, and lifetime are dependent upon the solvent. For example, the fluorescence intensity varies from being moderately strong in aqueous solution and very weak in hydrocarbon solvents. Addit

Specifications

Synonyms

10-Azaanthracene | UPCMLD-DP077:001 | ACRIDINE | Benzo[b]quinoline | acridine acid | Akridin [Czech] | 2,3-Benzoquinoline | ACRIDINE [MI] | Benzoquinolinylidene | 2,3,5,6-Dibenzopyridine | 9-Azaanthracene | Benzo(b)quinoline | Dibenzo(b,e)pyridine | Coal tar pitch volatiles: acridine | Acridines | Acridine (purified by sublimation) | Akri Show more

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Nucleic acid phosphate is a small cationic planar dye that mainly binds to RNA and DNA. Used for nucleic acid staining, especially cell cycle determination

Storage

Room temperature

Shipped In

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Action Type

DISRUPTING AGENT

Mechanism of action

DNA disrupting agent

Purity

≥98%

Product Properties

ALogP

3.4

Names and Identifiers

Pubchem Sid

488180942

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488180942

Canonical Smiles

C1=CC=C2C(=C1)C=C3C=CC=CC3=N2

IUPAC Name

acridine

InChIKey

DZBUGLKDJFMEHC-UHFFFAOYSA-N

INCHI

1S/C13H9N/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)14-12/h1-9H

Isomeric SMILES

C1=CC=C2C(=C1)C=C3C=CC=CC3=N2

WGK Germany

3

RTECS

AR7175000

UN Number

2713

Packing Group

III

Molecular Weight

179.22

Beilstein

120200

Reaxy-Rn

120200

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=120200&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Quinolines and derivatives
      • Subclass Benzoquinolines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Quinolines and derivatives
• Subclass: Benzoquinolines
• Intermediate Tree Nodes: Not available
• Direct Parent: Acridines
• Alternative Parents: Pyridines and derivatives Benzenoids Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Acridine - Benzenoid - Pyridine - Heteroaromatic compound - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as acridines. These are organic compounds containing the acridine moiety, a linear tricyclic heterocycle which consists of two benzene rings joined by a pyridine ring.
• External Descriptors: acridines - polycyclic heteroarene - mancude organic heterotricyclic parent

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

TOP2A Tclin DNA topoisomerase II alpha (6317 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHE Tclin Acetylcholinesterase (18204 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 Activities)

Discover Target: HTR3A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLA Tclin Alpha-galactosidase A (5444 Activities)

Discover Target: GLA

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ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

Discover Target: ALDH1A1

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A2780 (11979 Activities)

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FEN1 Tchem Flap endonuclease 1 (12055 Activities)

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POLI Tchem DNA polymerase iota (116820 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

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HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)

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SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)

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Associated Targets(non-human)

L1210 (27553 Activities)

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Calf thymus DNA (4845 Activities)

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

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Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FTL Ferritin light chain (43324 Activities)

Discover Target: FTL

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Mechanisms of Action

Chemical and Physical Properties

• Solubility: Very soluble in Ethanol,Ether,Benzene,Alcohol
• Boil Point(°C): 345-346°C
• Melt Point(°C): 111°C
• Molecular Weight: 179.220 g/mol
• XLogP3: 3.400
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 179.073 Da
• Monoisotopic Mass: 179.073 Da
• Topological Polar Surface Area: 12.900 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 181.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1