Labeling Rate >95%; Acrylic Acid Residual ≤100ppm for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Protected from light,Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
F127DA is a photosensitive polymer synthesized by acrylation modification of the terminal hydroxyl groups of Poloxamer 407 (F127). It can be used together with blue light or UV photoinitiators and crosslinks to form a solid network upon irradiation with blue light or ultraviolet light. This polymer features excellent biocompatibility, thermoresponsiveness and self-assembly capability. It cures easily and yields hydrogels with favorable mechanical properties capable of bearing high mechanical stress. It finds applications in drug delivery carriers, high-strength hydrogel fabrication, tissue engineering, wound dressings, biological 3D bioprinting, microfluidic chip manufacturing and other related fields.
Product Specifications
|
Recommended Operation
1. F127DA can be used in combination with o-nitrobenzyl-functionalized polymers such as HANB. The two components undergo photopolymerization and crosslinking triggered by photoinitiators under light irradiation, yielding high-strength hydrogel materials within only a few seconds.
2. F127DA can be blended with methacrylated polymers (CMCMA, HAMA, CSMA, ChMA) and acrylated polymers (e.g. PEGDA). Photopolymerization initiated by photoinitiators under light exposure enables fabrication of hydrogels with diversified physicochemical properties.
3. F127DA can be used independently to achieve photopolymerization and crosslinking with the aid of photoinitiators under light irradiation.
Preparation Protocol
1. Preparation of standard photoinitiator solution: Weigh a certain amount of sodium phenyl (2,4,6-trimethylbenzoyl) phosphinate (NAP) and dissolve it to prepare a solution with a mass fraction of 0.1 wt%–0.25 wt%. Store the solution away from light.
2. Transfer the required mass of F127DA into a centrifuge tube, add the standard initiator solution into the tube, and vortex thoroughly to fully wet F127DA.
3. For solutions with concentration ≤15 wt%, dissolve the sample by stirring or vortexing at room temperature. For concentrations above 15 wt%, place the sample at 2–8 °C for static dissolution, and vortex several times intermittently until complete dissolution.
Precautions
F127DA solutions with concentrations higher than 15 wt% tend to gel when kept at room temperature; higher concentrations lead to more pronounced gelation. The system will revert to a liquid state after cooling to 2–8 °C.
Product Applications
Drug delivery carriers, fabrication of high-strength hydrogels, tissue engineering, wound dressings, biological 3D bioprinting, microfluidic chip manufacturing, etc.
Sterilization Methods
1. Sterile filtration (Recommended): Sterilize the solution by filtration with a 0.22 μm sterile syringe filter.
2. Pasteurization: Heat the solution to 80 °C and hold for 30 min, then quickly transfer it into an ice-water mixture to cool to room temperature. Repeat the above process for three cycles in total.
3. Moist heat sterilization: Place the solution in an autoclave and sterilize at 121 °C for 8 min. After manual pressure release, immediately transfer the solution to an ice-water mixture and cool to room temperature.
4. Sterile solutions can be temporarily stored at 2–8 °C protected from light and are recommended for use within 7 days; non-sterile solutions can be temporarily stored at 2–8 °C and are recommended for use within 48 hours.
Product Features of F127DA
1. Self-assembly Property
The polymer chain is composed of hydrophilic PEO segments at both ends and relatively hydrophobic PPO segments in the middle. This unique structure enables the material to self-assemble into nanomicelles in water. The hydrophobic PPO segments aggregate inside the micelles to form a localized hydrophobic microenvironment, while the polar hydrophilic PEO segments extend outward to the micelle surface. Benefiting from such properties, this material can improve the solubility of hydrophobic drugs.
2. Thermoresponsiveness & Injectability
F127DA exists as a liquid at low temperatures and undergoes a liquid-to-gel transition near body temperature (approximately 20 °C to 40 °C). Therefore, it is injectable to achieve sustained and controlled drug release. Besides, it can be applied to formulate bioinks for 3D bioprinting.
3. Photosensitivity: In-situ fabrication of highly elastic, low-swelling hydrogels
Relying on its self-assembly capability, F127DA can form dispersed nanoparticles in aqueous solution. The double bond functional groups exposed on the nanoparticle surface allow F127DA to act as a crosslinker for fabricating high-strength composite hydrogels. Moreover, the presence of hydrophobic segments renders the hydrogel nearly non-swelling at 37 °C.
Typical Applications of F127DA
1. Loading of hydrophobic drugs; instant photo-crosslinkable hydrogels with high mechanical strength and strong adhesion for hemostasis at cardiac puncture wounds
2. Laryngeal cartilage defect repair: Fabrication of low-swelling and high-compressive-strength hydrogels to repair laryngeal cartilage defects.
3. Porous scaffold bioprinting: Implantation of porous scaffolds mixed with adipocytes for breast reconstruction.
Product Advantages of F127DA
1. Consistent batch performance: Standardized manufacturing processes ensure high repeatability and controllability of the chemical composition, physicochemical properties and biological performance of F127DA across different batches.
2. Ultra-high purity: Proprietary production processes efficiently remove small-molecule methacrylic acid and process impurities to achieve an ultra-low impurity profile, safeguarding the safety of F127DA for biomedical applications.
3. Proven biosafety: Every batch undergoes rigorous standardized testing prior to release to guarantee safety for biomedical use.
4. Excellent stability: Real-time and accelerated stability tests are conducted in accordance with the Guidelines for Stability Studies of Passive Implantable Medical Devices, verifying that F127DA maintains stable quality under the labeled storage conditions.
| PH | 5.0-7.5 |
|---|
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ26F0838443 | Certificate of Analysis | Aug 19, 2026 | P775160 |
| ZJ26F0838442 | Certificate of Analysis | Aug 19, 2026 | P775160 |
| ZJ26F0434393 | Certificate of Analysis | Apr 21, 2026 | P775160 |
| ZJ26F0333715 | Certificate of Analysis | Mar 31, 2026 | P775160 |
| ZJ26F0131077 | Certificate of Analysis | Jan 14, 2026 | P775160 |
| Sensitivity | Light sensitive |
|---|
