Adefovir - ≥98%(HPLC) , DNA polymerase/reverse transcriptase inhibitor, CAS No.106941-25-7, DNA polymerase/reverse transcriptase inhibitor

CAS: 106941-25-7 Cat. No.: A165714 Molecular Weight: 273.19 EC Number: 600-789-7

1 Citations COA

Skip to the end of the images gallery

Adefovir - ≥98%(HPLC) CAS No(106941-25-7) by Aladdin Scientific

Skip to the beginning of the images gallery

AVAILABLE TO ORDER

GRADE & PURITY ≥98%(HPLC)

Synonyms

Phosphonic acid, ((2-6-amino-9H-purin-9-YL)ethoxy)methyl | ADEFOVIR [WHO-DD] | DB13868 | ((2-6-amino-9H-purin-9-yl) ethoxy) methyl)- phosphonic acid. | 106941-25-7 (free acid) | BA166179 | HY-B1826 | AC-012 | GS-0393 | 2-(6-aminopurin-9-yl)ethoxymethylpho

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview Specifications Product Properties Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Documents & Articles Citations of This Product References Solution Calculators Reviews

🧪

Why this grade

≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 1 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses.

Specifications

Synonyms

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

Nucleotide analog reverse transcriptase inhibitor (K i = 100 nM, HBV DNA polymerase). Antiviral agent. cAMP analog. MRP4 substrate. Shows antireplication effects against hepatitis B in vivo. Orally active.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

DNA polymerase/reverse transcriptase inhibitor

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%(HPLC)

Product Properties

ALogP	-2

Names and Identifiers

Pubchem Sid	504753704
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504753704
Canonical Smiles	C1=NC(=C2C(=N1)N(C=N2)CCOCP(=O)(O)O)N
IUPAC Name	2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid
InChIKey	SUPKOOSCJHTBAH-UHFFFAOYSA-N
INCHI	1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)
Isomeric SMILES	C1=NC(=C2C(=N1)N(C=N2)CCOCP(=O)(O)O)N
WGK Germany	3
RTECS	SZ6563500
Molecular Weight	273.19
Reaxy-Rn	3561094
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3561094&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Imidazopyrimidines
    - Subclass Purines and purine derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Imidazopyrimidines
Subclass	Purines and purine derivatives
Intermediate Tree Nodes	Not available
Direct Parent	6-aminopurines
Alternative Parents	Aminopyrimidines and derivatives N-substituted imidazoles Imidolactams Organic phosphonic acids Heteroaromatic compounds Azacyclic compounds Primary amines Organopnictogen compounds Organophosphorus compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	6-aminopurine - Aminopyrimidine - N-substituted imidazole - Pyrimidine - Imidolactam - Azole - Imidazole - Organophosphonic acid - Organophosphonic acid derivative - Heteroaromatic compound - Azacycle - Organophosphorus compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organopnictogen compound - Amine - Primary amine - Organic oxide - Hydrocarbon derivative - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as 6-aminopurines. These are purines that carry an amino group at position 6. Purine is a bicyclic aromatic compound made up of a pyrimidine ring fused to an imidazole ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

ADA Tclin Adenosine deaminase (129 Activities)

Discover Target: ADA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AK2 Tbio Adenylate kinase 2 (264 Activities)

Discover Target: AK2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AK1 Tbio Adenylate kinase 1 (18 Activities)

Discover Target: AK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRPS1 Tbio Ribose-phosphate pyrophosphokinase I (25 Activities)

Discover Target: PRPS1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRPSAP2 Tbio Phosphoribosyl pyrophosphate synthetase-associated protein 2 (9 Activities)

Discover Target: PRPSAP2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

Lot Number	Certificate Type	Date	Item
D2027151	Certificate of Analysis	Nov 10, 2025	A165714
L2219141	Certificate of Analysis	Oct 11, 2025	A165714
F2111013	Certificate of Analysis	Mar 18, 2024	A165714
G2507105	Certificate of Analysis	Nov 29, 2023	A165714
K2317103	Certificate of Analysis	Nov 29, 2023	A165714

Solubility	solubility 0.1 M NaOH: ≥5 mg/mL;
Molecular Weight	273.190 g/mol
XLogP3	-2.000
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	5
Exact Mass	273.063 Da
Monoisotopic Mass	273.063 Da
Topological Polar Surface Area	136.000 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	327.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1