Selective, ATP-competitive PI3Kγ inhibitor
AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 250 nM, over 80-fold selectivity for PI3Kγ than PI3Kδ/β, and 18-fold more selective for PI3Kγ than PI3Kα.
An ATP-competitive inhibitor of PI 3-kinase γ.
| CAS | 648449-76-7 |
|---|---|
| Synonyms | (E)-5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione | AS604850 | AS-604850 | HY-13531 | (5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLIDENE]-1,3-THIAZOLIDINE-2,4-DIONE | NCGC00387765-03 | C76032 | 5-(2,2-difluorobenzo(1,3)diox |
| Specifications & Purity | Moligand™, ≥98% |
| Storage | Store at 2-8°C |
| Shipped In | Wet ice |
| Product Description | AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 250 nM, over 80-fold selectivity for PI3Kγ than PI3Kδ/β, and 18-fold more selective for PI3Kγ than PI3Kα. |
| Pubchem Sid | 504766482 |
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504766482 |
| Solubility | Soluble in DMSO (>10 mg/ml), water (<2 mg/ml), acetonitrile (6 mg/ml), methanol (9 mg/ml), and 100% ethanol. |
| Mdl Number | MFCD19705528 |
| EC Number | 636-351-7 |
| PubChem CID | 11492951 |
| Molecular Formula | C11H5F2NO4S |
