(±)-Camphor - Moligand™, ≥96% , Gating inhibitor of TRPA1;Activator of TRPV1;Activator of TRPV3, CAS No.76-22-2, Gating inhibitor of TRPA1;Activator of TRPV1;Activator of TRPV3

CAS: 76-22-2 Cat. No.: C110690 Molecular Weight: 152.23 Beilstein Registry Number: 1907611 EC Number: 200-945-0

GRADE & PURITY Moligand™, ≥96%

Synonyms

Alphanon | dl-Camphor (JP17) | 1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one | CCG-266237 | CCG-266238 | NCGC00090730-02 | KBio1_000724 | Sarna (Salt/Mix) | Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (1R)- | SYNTHETIC CAMPHOR | C1251 | Camphor, (1R,4R)-(+)

Storage

Room temperature

Shipped In

Normal

Overview

Camphor is a novel carbon nanotube precursor.
Camphor was used in the synthesis of single-walled nanotubes by chemical vapor deposition. It was used in two-phase based hollow fibre liquid-phase microextraction procedure for migration analysis of food packagings containing essential oils.

Specifications

Synonyms

Alphanon | dl-Camphor (JP17) | 1, 7, 7-Trimethylbicyclo[2.2.1]heptan-2-one | CCG-266237 | CCG-266238 | NCGC00090730-02 | KBio1_000724 | Sarna (Salt/Mix) | Bicyclo[2.2.1]heptan-2-one, 1, 7, 7-trimethyl-, (1R)- | SYNTHETIC CAMPHOR | C1251 | Camphor, (1R, 4R)-(+)

Specifications & Purity

Moligand™, ≥96%

Storage

Room temperature

Shipped In

Normal

Grade

Moligand™

Action Type

ACTIVATOR, GATING INHIBITOR

Mechanism of action

Gating inhibitor of TRPA1;Activator of TRPV1;Activator of TRPV3

Purity

≥96%

Names and Identifiers

• Pubchem Sid: 504750577
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504750577
• Canonical Smiles: CC1(C2CCC1(C(=O)C2)C)C
• IUPAC Name: 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
• InChIKey: DSSYKIVIOFKYAU-UHFFFAOYSA-N
• INCHI: 1S/C10H16O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7H,4-6H2,1-3H3
• Isomeric SMILES: CC1(C2CCC1(C(=O)C2)C)C
• WGK Germany: 3
• RTECS: EX1225000
• Alternate CAS: 21368-68-3
• UN Number: 2717
• Packing Group: III
• Molecular Weight: 152.23
• Beilstein: 1907611
• Reaxy-Rn: 1907611
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1907611&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Class Prenol lipids
      • Subclass Monoterpenoids

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Class: Prenol lipids
• Subclass: Monoterpenoids
• Intermediate Tree Nodes: Not available
• Direct Parent: Bicyclic monoterpenoids
• Alternative Parents: Ketones Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aliphatic homopolycyclic compounds
• Substituents: Bicyclic monoterpenoid - Bornane monoterpenoid - Ketone - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Aliphatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as bicyclic monoterpenoids. These are monoterpenoids containing exactly 2 rings, which are fused to each other.
• External Descriptors: a small molecule

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

TRPV3 Tchem Transient receptor potential cation channel subfamily V member 3 (1 Activities)

Discover Target: TRPV3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPV1 Tclin Transient receptor potential cation channel subfamily V member 1 (0 Activities)

Discover Target: TRPV1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 (1 Activities)

Discover Target: TRPA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Associated Targets(non-human)

Plasmodium berghei (192651 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Solubility in water: 1.5 g/L (20°C) Solubility in other solvents: at 25°C 1 g dissolves in 1 ml Alcohol, 1 ml Ether, 0.5 ml Chloroform, 0.4 ml Benzene, 0.4 ml Acetone, 1.5 ml Turpentine oil, 0.5 ml Glacial acetic acid.
• Sensitivity: Moisture sensitive.
• Flash Point(°F): 147.2 °F
• Flash Point(°C): 65.5℃
• Boil Point(°C): 204°C
• Melt Point(°C): 175-177°C
• Molecular Weight: 152.230 g/mol
• XLogP3: 2.200
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 152.12 Da
• Monoisotopic Mass: 152.12 Da
• Topological Polar Surface Area: 17.100 Ų
• Heavy Atom Count: 11
• Formal Charge: 0
• Complexity: 217.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 2
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Shishi Shao, Jiaqiang Zhao, Wei Wang, Hanbing Nie, Yan Jie Li, Xuepeng Zhang, Cheng Zhi Huang, Peng Fei Gao.  (2023)  Ratiometric room-temperature phosphorescence platform for visual and spectral analysis of naphthalene.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2023.135047]

2. Yuyan Cai, Haozhe Xu, Chenyi Xu, Zhaojiang Zuo.  (2023)  Adjusting function of camphor on primary metabolism in Cinnamomum camphora stressed by high temperature.  PLANT SCIENCE,      [PMID:38101618] [10.1016/j.plantsci.2023.111956]

3. Tianyu Huang, Meng Lai, Zhenwei Lin, Ruiqi Luo, Xuezheng Xiang, Haozhe Xu, Ning Pan, Zhaojiang Zuo.  (2023)  Identification of algicidal monoterpenoids from four chemotypes of Cinnamomum camphora and their algicidal mechanisms on Microcystis aeruginosa.  ENVIRONMENTAL RESEARCH,      [PMID:37989462] [10.1016/j.envres.2023.117714]

4. Qian Pan, Junhui Hu, Chengzhi Hu, Ying Yan.  (2023)  Reparation and characterization of carbon nanotubes coated on expanded perlite as sound absorption composite materials.  Materials Science and Engineering B-Advanced Functional Solid-State Materials,      [PMID:] [10.1016/j.mseb.2023.116697]

5. Chengzhi Hu, Huiping Zhang, Ying Yan.  (2023)  Toluene combustion over Co3O4-CNTs/PSSF catalysts and investigation of the effects of acid treatment on catalytic activity.  Journal of the Taiwan Institute of Chemical Engineers,      [PMID:] [10.1016/j.jtice.2023.105002]

6. Xiaomin Zhang, Gaofeng Hu, Chaoyang Xu, Wen Nie, Kezhou Cai, Hongmei Fang, Baocai Xu.  (2023)  Inhibition of benzo[a]pyrene formation in charcoal-grilled pork sausages by ginger and its key compounds.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,  103  (6): (2838-2847).  [PMID:36700254] [10.1002/jsfa.12470]

7. Ying Yan, Chengzhi Hu, Zijian Wang, Huiping Zhang.  (2023)  Mass transfer enhancement of toluene adsorption over CNTs films on paper-like sintered stained steel fibers.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2023.130955]

8. Meichao Liao, Lin Yang, Xiaoyue Yang, Erxu Wang, Bin Lu, Jiye Wang, Li Duan.  (2022)  Vortex-assisted liquid–liquid microextraction based on hydrophobic deep eutectic solvent for the urinary excretion study of Taraxacum mongolicum extract in rats.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2022.108167]

9. Xinying Duan, Li Zhang, Hongyan Si, Jie Song, Peng Wang, Shangxing Chen, Hai Luo, Xiaoping Rao, Zongde Wang, Shengliang Liao.  (2022)  Synthesis, Antifungal Activity, Cytotoxicity and QSAR Study of Camphor Derivatives.  Journal of Fungi,  8  (8): (762).  [PMID:35893130] [10.3390/jof8080762]

10. Meichao Liao, Yang Zhao, Xiaoyue Yang, Lin Yang, E-Hu Liu, Bin Lu, Jiye Wang, Xiaopeng Liu, Yanzhong Chang, Li Duan.  (2022)  A greener and sustainable route for medicinal plant analysis: Recycle utilization of hydrophobic deep eutectic solvent.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2022.107372]

11. Xu Chenyi, Ma Yuandan, Tian Zhengfeng, Luo Qingyun, Zheng Tiefeng, Wang Bin, Zuo Zhaojiang.  (2021)  Monoterpene emissions and their protection effects on adult Cinnamomum camphora against high temperature.  TREES-STRUCTURE AND FUNCTION,  36  (2): (711-721).  [PMID:] [10.1007/s00468-021-02242-4]

12. Jing Li, Yanjun Jiao, Qin Luo, Weixin Hu, Shenwen Fang, Chunling Tang, Qiang Liu.  (2021)  Treatment of oil-based drill cuttings by hydrophobic deep eutectic solvents.  CANADIAN JOURNAL OF CHEMICAL ENGINEERING,  100  (8): (1747-1754).  [PMID:] [10.1002/cjce.24263]

13. Zhengfeng Tian, Qingyun Luo, Zhaojiang Zuo.  (2021)  Seasonal emission of monoterpenes from four chemotypes of Cinnamomum camphora.  INDUSTRIAL CROPS AND PRODUCTS,      [PMID:] [10.1016/j.indcrop.2021.113327]

14. Xiao‑Yu Li, Li Xu, Hong‑Li Li, Jing Du, Xue‑Song Liu, Feng‑Hua Li.  (2017)  Au-poly(lactic-co-glycolic) acid complex nanoparticles as ultrasound contrast agents: Preparation, characterization and in vitro study.  Molecular Medicine Reports,  17  (3): (3763-3768).  [PMID:29286171] [10.3892/mmr.2017.8351]

15. Junling He, Yong Tang, Chiliang Lin, Shaoyun Peng, Stig Pedersen-Bjergaard, Frederik André Hansen, Chen Zhou.  (2024)  Electromembrane extraction of multi-class prohibited/restricted veterinary drugs from food samples – Exploring liquid membrane composition.  FOOD CHEMISTRY,      [PMID:39733624] [10.1016/j.foodchem.2024.142680]

16. You Zhou, De Qiang Qin, Min Xing Zhang, Miao Sun, Lu Sheng Wan, Jing Sheng Chen.  (2024)  Exploring bioactive molecules with fumigation toxicity against the red imported fire ant Solenopsis invicta Buren from commercial essential oils by GC–MS combined with chemometrics.  INDUSTRIAL CROPS AND PRODUCTS,      [PMID:] [10.1016/j.indcrop.2023.117993]