Candesartan , CAS No.139481-59-7

CAS: 139481-59-7 Cat. No.: C1372323-GMP Molecular Weight: 440.45 EC Number: 604-138-8

Storage

Room temperature

Shipped In

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Overview

Candesartan (GMP) (CV 11974 (GMP)) is a GMP grade Candesartan. GMP grade small molecules can be used as auxiliary reagents in cell therapy. Candesartan is an angiotensin II AT1 receptor blocker and PPAR - γ agonist. Candesartan has strong and long-lasting anti hypertensive effects. Candesartan can be used for research on hypertension, chronic heart failure (CHF), and traumatic brain injury (TBI).

Specifications

Storage

Room temperature

Shipped In

Normal

Product Properties

• ALogP: 4.1

Names and Identifiers

• Canonical Smiles: CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)O
• IUPAC Name: 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid
• InChIKey: HTQMVQVXFRQIKW-UHFFFAOYSA-N
• INCHI: 1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,31,32)(H,26,27,28,29)
• Isomeric SMILES: CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)O
• Alternate CAS: 139481-59-7
• NSC Number: 759858
• MeSH Entry Terms: 2-ethoxy-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1H-benzimidazole-7-carboxylic acid;2-ethoxy-7-carboxy-1-(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methylbenzimidazole;candesartan;CV 11974;CV-11974;CV11974
• Molecular Weight: 440.45
• Reaxy-Rn: 9232176
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9232176&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Biphenyls and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Biphenyls and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Biphenyls and derivatives
• Alternative Parents: Phenyltetrazoles and derivatives Benzimidazoles Alkyl aryl ethers N-substituted imidazoles Vinylogous amides Heteroaromatic compounds Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Biphenyl - Phenyltetrazole - Benzimidazole - Alkyl aryl ether - N-substituted imidazole - Azole - Imidazole - Heteroaromatic compound - Vinylogous amide - Tetrazole - Carboxylic acid derivative - Carboxylic acid - Ether - Monocarboxylic acid or derivatives - Azacycle - Organoheterocyclic compound - Organic oxygen compound - Hydrocarbon derivative - Organopnictogen compound - Organic oxide - Organonitrogen compound - Organooxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
• External Descriptors: biphenylyltetrazole - benzimidazolecarboxylic acid

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Freezing Point(°C): 183-185°C

References

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2. Liang Song, Weiwei Zheng, Shuqin Wang, Zihe Zhai, Shifen Li, Jie Ding, Liyin Shen, Jinyue Zhang, Yang Zhu, Changyou Gao.  (2025)  ROS-responsive core–shell microgels for phase-specific treatment of myocardial infarction via programmed drug delivery.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.160295]

3. Dafa Yi, Jiazong Ye, Zebei Lu, Leilei Lu, Tengfei Qi, Tong Luo, Xiuyun Peng, Abdullah Al Mamun, Quan Zhou, Daqing Chen, Shuanghu Wang.  (2025)  Effects of anti-hypertensive drugs on the metabolism of mobocertinib in rats both in vitro and in vivo.  DRUG METABOLISM AND DISPOSITION,      [PMID:40482432] [10.1016/j.dmd.2025.100094]

4. Zhenyu Wu, Xufang Huo, Yubing Huang, Taowu Gong, Pengcheng Zhao, Yuhang Zhu, Qingfan Zeng.  (2026)  AngII promotes hippocampal neuron ferroptosis via inhibiting the PPARγ/ACSL3 axis leading to hypertension-related cognitive impairment.  EXPERIMENTAL NEUROLOGY,      [PMID:] [10.1016/j.expneurol.2026.115755]