Complement C3c from Human Plasma, CAS No.80295-41-6

CAS: 80295-41-6 Cat. No.: np001103 Molecular Weight: 185,000 Da (2 chains)

GRADE & PURITY BioReagent, Native, PBS Only, ≥95%(SDS-PAGE), Protein concentration: See COA

Accession #

P01024

Overview

Complement C3 (C3) is the most abundant component of the complement system, with levels in human plasma of ~1.2-1.5 mg/ml. It is central to the activation of both the classical and alternative complement pathways, both of which lead to the proteolytic processing of C3 to C3a and C3b. C3 exists as a heterodimer with molecular masses of 115 kDa and 75 kDa, although it is readily processed to create C3a, C3b or C3c depending on the processed state.

Purity: ≥95% by SDS-PAGE.

Reacts to C3 antisera on Western Blot

Negative against C4 antisera on Western Blot

Not biologically active.

Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Specifications

Product Name

Complement C3c from Human Plasma, CAS No.80295-41-6

Synonyms

C3 | Complement C3 | ASP | C3a | C3b | AHUS5 | ARMD9 | CPAMD1 | HEL-S-62p

Grade

BioReagent, Native, PBS Only

Specifications & Purity

BioReagent, Native, PBS Only, ≥95%(SDS-PAGE), Protein concentration: See COA

Biochemical and Physiological Mechanisms

Precursor of non-enzymatic components of the classical, alternative, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune syste

Accession #

P01024

Predicted molecular weight

138 kDa

CAS

80295-41-6

Molecule Type

Protein

Storage and Shipping

Shape

Frozen in PBS, pH 7.4

Concentration

Protein concentration: See COA

Storage

Store at -80°C,Avoid repeated freezing and thawing

Shipped In

Dry ice packs + Cold packs

Stability And Storage

Store at -80℃ long term (>1 year). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.