Doxycycline hyclate - Moligand™, ≥98% , CAS No.24390-14-5

CAS: 24390-14-5 Cat. No.: D111943 Formula: C₂₂H₂₄N₂O₈·HCl·0.5H₂O·0.5C₂H₆O Molecular Weight: 512.94 Beilstein Registry Number: 5702728 EC Number: 657-194-0 PubChem CID: 54686183

GRADE & PURITY Moligand™, ≥98%

Synonyms

Doxycycline hydrochloride hydrate (JP17) | Periostat | AKOS025402170 | DOXYCYCLINE HYCLATE [VANDF] | DOXYCYCLINE HYCLATE [ORANGE BOOK] | Doxycycline hyclate 100 microg/mL in Acetonitrile | trans-1,3-Pentadiene, analytical standard | Doxycycline hyclate (i

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

Inhibits matrix metalloproteinases at subantimicrobial doses.Doxycycline hyclate is an antibacterial antibiotic, which is used in the treatment of chlamydia, rickettsia, mycoplasma and some spirochete infections. It is also used to inhibit matrix metalloproteinases at subantimicrobial doses.

A commonly used broad-spectrum antibiotic. A potent inhibitor of MMP-8 (neutrophil collagenase; IC50 = 30 µM) relative to MMP-1 (collagenase-1; IC50 = 300 µM). Also inhibits collagen synthesis by bovine articular chondrocytes cultured in alginate (IC50 = 25 µM). Inhibits nitric oxide synthesis by LPS-activated macrophages without affecting IL-10 release.

Specifications

Synonyms

Doxycycline hydrochloride hydrate (JP17) | Periostat | AKOS025402170 | DOXYCYCLINE HYCLATE [VANDF] | DOXYCYCLINE HYCLATE [ORANGE BOOK] | Doxycycline hyclate 100 microg/mL in Acetonitrile | trans-1,3-Pentadiene, analytical standard | Doxycycline hyclate (i

Specifications & Purity

Moligand™, ≥98%

Biochemical and Physiological Mechanisms

Cell permeability: No. Primary target: MMP-8. Does not compete with ATP. Reversibility: No. Synthesized as tetracycline; an inhibitor of matrix metalloproteinases (MMPs). Inhibits tumor growth, cell proliferation, and induces apoptosis both in vitro and i

Application

Broad-spectrum antibiotic, a derivative of oxytetracycline. A broad-spectrum inhibitor of metalloproteinases in the body.

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

Pubchem Sid

504771368

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504771368

Canonical Smiles

CCO.CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O.Cl.Cl

IUPAC Name

(4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;ethanol;hydrate;dihydrochloride

InChIKey

UHHHTIKWXBRCLT-VDBOFHIQSA-N

INCHI

1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25-27,30,32H,1-3H3,(H2,23,31);3H,2H2,1H3;2*1H;1H2/t2*7-,10+,14+,15-,17-,22-;;;;/m00..../s1

Isomeric SMILES

CCO.C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O.Cl.Cl

WGK Germany

3

RTECS

QI8925000

Alternate CAS

10592-13-9

PubChem CID

54686183

Molecular Weight

512.94

Beilstein

5702728

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in water, methanol. Sparingly soluble in ethanol. Insoluble in chloroform and ether.
• Specific Rotation[α]: -104° (C=1,0.01mol/L HCl(MeOH))
• Molecular Weight: 1025.900 g/mol
• Hydrogen Bond Donor Count: 16
• Hydrogen Bond Acceptor Count: 20
• Rotatable Bond Count: 4
• Exact Mass: 1024.31 Da
• Monoisotopic Mass: 1024.31 Da
• Topological Polar Surface Area: 384.000 Ų
• Heavy Atom Count: 70
• Formal Charge: 0
• Complexity: 958.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 12
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 6

XLogP3

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at 2–8 °C. Refrigerated storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 24390-14-5, the molecular formula is C22H24N2O8·HCl·0.5H2O·0.5C2H6O, and the molecular weight is 512.94 g/mol. InChIKey UHHHTIKWXBRCLT-VDBOFHIQSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.