10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 1 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Equol ,a metabolite of soybeans, is an important isoflavone in humans，specifically binds to 5α-DHT, has a modest affinity for recombinant estrogen receptor ERβ. Phase 2.
In vitro
Equol is a metabolite produced from the soy phytoestrogen daidzein by the action of gut microflora. Equol has higher affinity for both ERs (estrogen receptors including ERalpha and ERbeta). Equol exists as the enantiomers R-equol and S-equol. S-equol has a high binding affinity, preferential for ERbeta with a Ki of 16 nM whereas R-equol binds more weakly and with a preference for ERalpha K with a Ki of 50 nM. Equol is superior to all other isoflavones in its antioxidant activity. Equol has antioestrogenic properties. Equol is a 100-fold more potent than daidzein in stimulating an oestrogenic response. Equol is also more effective than daidzein in competing with 3 H-oestradiol for binding to the ER. Equol stimulates the growth of MCF-7 cells in a concentration-dependent manner. Although equol exhibits oestrogenic activity, exposure of MCF-7 cells to equol simultaneously with oestradiol is effective in reducing pS2 mRNA expression. Equol results in the downregulation of ER mRNA expression.
In vivo
Cell Data
cell lines：
Concentrations：0 μM-10 μM
Incubation Time：24 hours
Powder Purity:≥99%
| ALogP | 3 |
|---|
| Isomeric SMILES | C1[C@H](COC2=C1C=CC(=C2)O)C3=CC=C(C=C3)O |
|---|---|
| RTECS | DJ2887080 |
| Alternate CAS | 221054-79-1；94105-90-5 |
| Molecular Weight | 242.27 |
| Reaxy-Rn | 87753 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=87753&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Solubility | Solubility (25°C) In vitro DMSO: 31 mg/mL (196.0 mM); Water: 31 mg/mL (196.0 mM); Ethanol: Insoluble; |
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| 1. Zhou Lu, Yat-Tin Chan, Kenneth Ka-Hei Lo, Vincy Wing-Si Wong, Yuk-Fan Ng, Shi-Ying Li, Wing-Wa Ho, Man-Sau Wong, Danyue Zhao. (2021) Levels of polyphenols and phenolic metabolites in breast milk and their association with plant-based food intake in Hong Kong lactating women. Food & Function, 12 (24): (12683-12695). [PMID:34825914] [10.1039/D1FO02529E] |
