1-Chloro-2,2,2-trifluoroethyl Difluoromethyl Ether - Moligand™, ≥98%(GC) , Potassium channel subfamily K member 2 opener, CAS No.26675-46-7, Potassium channel subfamily K member 2 opener

CAS: 26675-46-7 Cat. No.: C153359 Molecular Weight: 184.49 EC Number: 247-897-7
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(GC)
Synonyms
BBL100111 | SY050218 | A818554 | CAS-26675-46-7 | Isoflurano [INN-Spanish] | IsoSol | STL454337 | TerrellHSDB 8057 | C2485 | ISOFLURANE (EP MONOGRAPH) | CHEBI:6015 | HSDB-8057 | N01AB06 | NCGC00181037-02 | ATTANE | Compound 469 | Ethane, 2-chloro-2-(diflu
Storage
Store at 2-8°C
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
1g
C153359-1g
2
$9.90
5g
C153359-5g
4
$19.90
25g
C153359-25g
1
$63.90
100g
C153359-100g
3
$139.90
500g
C153359-500g
3
$539.90
Enter a quantity for the sizes you want to add.
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Why this grade

Moligand™, ≥98%(GC) Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 24 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Used only for R&D experiments

Specifications

Synonyms
BBL100111 | SY050218 | A818554 | CAS-26675-46-7 | Isoflurano [INN-Spanish] | IsoSol | STL454337 | TerrellHSDB 8057 | C2485 | ISOFLURANE (EP MONOGRAPH) | CHEBI:6015 | HSDB-8057 | N01AB06 | NCGC00181037-02 | ATTANE | Compound 469 | Ethane, 2-chloro-2-(diflu
Specifications & Purity
Moligand™, ≥98%(GC)
Storage
Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
ACTIVATOR, POSITIVE MODULATOR
Mechanism of action
Potassium channel subfamily K member 2 opener
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Purity
≥98%(GC)
Product Properties
ALogP2.1
Names and Identifiers
Pubchem Sid488179792
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488179792
Canonical SmilesC(C(F)(F)F)(OC(F)F)Cl
IUPAC Name2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane
InChIKeyPIWKPBJCKXDKJR-UHFFFAOYSA-N
INCHI1S/C3H2ClF5O/c4-1(3(7,8)9)10-2(5)6/h1-2H
Isomeric SMILES C(C(F)(F)F)(OC(F)F)Cl
RTECS KN6799000
Molecular Weight 184.49
Reaxy-Rn 1852087
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1852087&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganohalogen compounds
ClassOrganofluorides
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentOrganofluorides
Alternative Parents Organooxygen compounds  Organochlorides  Hydrocarbon derivatives  Alkyl fluorides  Alkyl chlorides  
Molecular FrameworkAliphatic acyclic compounds
Substituents Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Organofluoride - Organochloride - Alkyl halide - Alkyl fluoride - Alkyl chloride - Aliphatic acyclic compound
DescriptionThis compound belongs to the class of organic compounds known as organofluorides. These are compounds containing a chemical bond between a carbon atom and a fluorine atom.
External Descriptors organofluorine compound
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNK2 Tclin Potassium channel subfamily K member 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNK3 Tclin Potassium channel subfamily K member 3 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNK16 Tbio Potassium channel subfamily K member 16 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Canis familiaris (36305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Kcnk3 Potassium channel subfamily K member 3 (21 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

38 results found

Lot NumberCertificate TypeDateItem
C2223483Certificate of AnalysisJan 19, 2026 C153359
L2509329Certificate of AnalysisNov 26, 2025 C153359
L2509327Certificate of AnalysisNov 26, 2025 C153359
L2509328Certificate of AnalysisNov 26, 2025 C153359
B2525255Certificate of AnalysisFeb 08, 2025 C153359
B2525257Certificate of AnalysisFeb 08, 2025 C153359
B2525258Certificate of AnalysisFeb 08, 2025 C153359
B2525259Certificate of AnalysisFeb 08, 2025 C153359
B2525260Certificate of AnalysisFeb 08, 2025 C153359
J2516022Certificate of AnalysisFeb 08, 2025 C153359
K2404167Certificate of AnalysisOct 24, 2024 C153359
K2404166Certificate of AnalysisOct 24, 2024 C153359
K2404165Certificate of AnalysisOct 24, 2024 C153359
K2404153Certificate of AnalysisOct 24, 2024 C153359
K2404152Certificate of AnalysisOct 24, 2024 C153359
F2417168Certificate of AnalysisJun 04, 2024 C153359
F2417170Certificate of AnalysisJun 04, 2024 C153359
F2417169Certificate of AnalysisJun 04, 2024 C153359
F2417166Certificate of AnalysisJun 04, 2024 C153359
F2417154Certificate of AnalysisJun 04, 2024 C153359
F2417167Certificate of AnalysisJun 04, 2024 C153359
B2028066Certificate of AnalysisDec 14, 2023 C153359
C23101292Certificate of AnalysisMar 22, 2023 C153359
B2309276Certificate of AnalysisFeb 14, 2023 C153359
B2309272Certificate of AnalysisFeb 14, 2023 C153359
B2309305Certificate of AnalysisFeb 14, 2023 C153359
I2220218Certificate of AnalysisJul 20, 2022 C153359
I2220219Certificate of AnalysisJul 20, 2022 C153359
I2220220Certificate of AnalysisJul 20, 2022 C153359
K2330172Certificate of AnalysisJul 20, 2022 C153359
C2414054Certificate of AnalysisJul 20, 2022 C153359
I2220217Certificate of AnalysisJul 20, 2022 C153359
I2220216Certificate of AnalysisJul 20, 2022 C153359
H1823083Certificate of AnalysisJun 22, 2022 C153359
F2307074Certificate of AnalysisFeb 23, 2022 C153359
C2223493Certificate of AnalysisFeb 23, 2022 C153359
C2223492Certificate of AnalysisFeb 23, 2022 C153359
C2223485Certificate of AnalysisFeb 23, 2022 C153359

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Chemical and Physical Properties
SolubilitySoluble in chloroform and ethyl acetate. Not miscible or difficult to mix in water.
Refractive Index1.302
Boil Point(°C)48-49℃
Molecular Weight184.490 g/mol
XLogP32.100
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass183.971 Da
Monoisotopic Mass183.971 Da
Topological Polar Surface Area9.200 Ų
Heavy Atom Count10
Formal Charge0
Complexity102.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Shuanghui Lu, Xiu Chen, Yujia Chen, Yingqiong Zhang, Jun Luo, Huidi Jiang, Luo Fang, Hui Zhou.  (2023)  Downregulation of PDZK1 by TGF-β1 promotes renal fibrosis via inducing epithelial-mesenchymal transition of renal tubular cells.  BIOCHEMICAL PHARMACOLOGY,      [PMID:38158021] [10.1016/j.bcp.2023.116015]
2. Ruiqing Zhou, Chengqing Huang, Nanxi Bi, Ling Li, Changqing Li, Xiaozhen Gu, Yang Song, Hui-Li Wang.  (2023)  Chronic Pb Exposure Induces Anxiety and Depression-like Behaviors in Mice via Excitatory Neuronal Hyperexcitability in Ventral Hippocampal Dentate Gyrus.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,      [PMID:37559393] [10.1021/acs.est.3c03426]
3. Xiao Zhang, Yating Ma, Xiaojian Zhang, Xin Pang, Zhiheng Yang.  (2023)  Bio-inspired self-assembled bacteriochlorin nanoparticles for superior visualization and photothermal ablation of tumors.  BIOMEDICINE & PHARMACOTHERAPY,      [PMID:37327585] [10.1016/j.biopha.2023.115014]
4. Zhuang Kejin, Meng Weihong, Shu Xin, Liang Defu, Wang Lidong, Zhang Dongjie.  (2023)  Fecal metabonomics combined with 16S rDNA sequencing to analyze the changes of gut microbiota in rats fed with different protein source diets.  EUROPEAN JOURNAL OF NUTRITION,  62  (6): (2687-2703).  [PMID:37273002] [10.1007/s00394-023-03168-y]
5. Rongrong Wang, Zhi-Hua Liu, Nanxi Bi, Xiaozhen Gu, Chengqing Huang, Ruiqing Zhou, Haoyu Liu, Hui-Li Wang.  (2023)  Dysfunction of the medial prefrontal cortex contributes to BPA-induced depression- and anxiety-like behavior in mice.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:37210999] [10.1016/j.ecoenv.2023.115034]
6. Haibo Du, Lianqin Ding, Tian Zeng, Di Li, Li Liu.  (2022)  LncRNA SNHG15 Modulates Ischemia-Reperfusion Injury in Human AC16 Cardiomyocytes Depending on the Regulation of the miR-335-3p/TLR4/NF-κB Pathway.  International Heart Journal,  63  (3): (578-590).  [PMID:] [10.1536/ihj.21-511]
7. Wang Fei, Li Wu-lin, Shen Li-juan, Jiang Ting-ting, Xia Jian-jun, You Da-li, Hu Shan-you, Wang Li, Wu Xiao.  (2022)  Crocin Alleviates Intracerebral Hemorrhage–Induced Neuronal Ferroptosis by Facilitating Nrf2 Nuclear Translocation.  NEUROTOXICITY RESEARCH,  40  (2): (596-604).  [PMID:35380368] [10.1007/s12640-022-00500-y]
8. Huang Yuxing, Deng Lisha, Zeng Lin, Bao Shanlin, Ye Kun, Li Chengxun, Hou Xiaolin, Yao Yuan, Li Dingjun, Xiong Zhen.  (2021)  Silencing of H19 alleviates oxygen–glucose deprivation/reoxygenation-triggered injury through the regulation of the miR-1306-5p/BCL2L13 axis.  METABOLIC BRAIN DISEASE,  36  (8): (2461-2472).  [PMID:34436746] [10.1007/s11011-021-00822-4]
9. Haijuan Hu, Shanshan Zhang, Fengxia Liu, Peipei Zhang, Zafarullah Muhammad, Siyi Pan.  (2019)  Role of the Gut Microbiota and Their Metabolites in Modulating the Cholesterol-Lowering Effects of Citrus Pectin Oligosaccharides in C57BL/6 Mice.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:31576748] [10.1021/acs.jafc.9b03731]
10. Zhuang Kejin, Shu Xin, Meng Weihong, Zhang Dongjie.  (2024)  Blended-protein changes body weight gain and intestinal tissue morphology in rats by regulating arachidonic acid metabolism and secondary bile acid biosynthesis induced by gut microbiota.  EUROPEAN JOURNAL OF NUTRITION,      [PMID:38512357] [10.1007/s00394-024-03359-1]
11. Junli Du, Chao Chen, Jie Chen.  (2024)  Cirsilineol improves anesthesia/surgery-induced postoperative cognitive dysfunction through attenuating oxidative stress and modulating microglia M1/M2 polarization.  PeerJ,      [PMID:39559329] [10.7717/peerj.18507]
12. Su Ziyang, Kong Rui, Huang Chengqing, Wang Kun, Liu Chenhao, Gu Xiaozhen, Wang Hui-Li.  (2025)  Exposure to polystyrene nanoplastics causes anxiety and depressive-like behavior and down-regulates EAAT2 expression in mice.  ARCHIVES OF TOXICOLOGY,      [PMID:40019525] [10.1007/s00204-025-04002-6]
13. Lian Hui, Xu Kai, Chang Airu, Wang Yaxuan, Ma Shuaichen, Cheng Lianhui, Zhao Wenyu, Xia Cong, Wang Lan, Yu Guoying.  (2024)  Loss of PTPN21 disrupted mitochondrial metabolic homeostasis and aggravated experimental pulmonary fibrosis.  RESPIRATORY RESEARCH,  25  (1): (1-20).  [PMID:39633451] [10.1186/s12931-024-03041-4]
14. Nanxi Bi, Chengqing Huang, Xiaozhen Gu, Rongrong Wang, Haoyu Liu, Ruiqing Zhou, Heyujia Zhang, Xiang-Tao Chen, Hui-Li Wang.  (2025)  Bisphenol A Impairs Spatial Memory by Inhibiting Hippocampal Excitatory Neuronal Response During Learning Events.  Environment & Health,      [PMID:41306306] [10.1021/envhealth.5c00110]
15. Li Zhaohan, Yang Jun, Li Jianan, Zhao Shuxuan, Jiang Shaoping, Liu Weimin, Li Xinjian, Zhang Simeng, Du Haiyan, Ni Junjun, Huang Yuanyu, Qing Hong, Ruan Shaobo.  (2025)  Targeted delivery of BACE1 siRNA for synergistic treatment of Alzheimer's disease.  Translational Neurodegeneration,  14  (1): (1-20).  [PMID:40814010] [10.1186/s40035-025-00503-7]
16. Fang Cheng, Minzhu Zhao, Qi Wang, Hongli Xiong, Kai Yu, Chong Chen, Ying Zhu, Yemiao Chen, Jianbo Li.  (2025)  FOXO1-NMNAT3 axis dysregulation promotes doxorubicin cardiotoxicity: NAD+ replenishment as a redox-targeted antioxidant therapy.  REDOX REPORT,      [PMID:41021886] [10.1080/13510002.2025.2565033]
17. Hongtao Zhang, Yi Huang, Songhong Yang, Feipeng Gong, Yuncheng Gu, Qin Xie, Yanrong Ye, Xingmei Lu, Lingyun Zhong.  (2025)  Improved myocardial mitochondrial energy metabolism in rats with chronic heart failure by modifying fatty acid oxidation using an extract of sand-fired aconite (Jianchang gang processing).  Frontiers in Pharmacology,      [PMID:41019998] [10.3389/fphar.2025.1600410]
18. Ziyan Han, Yuzhou Zhuo, Zhihui Dai, Xinhui Zhang, Bingqian Zhu, Yuyan Liu, Zhuoyu Chai, Jiayi Wu, Lijun Chen.  (2025)  The safety assessment of cinnabar: Effects of co-administration with selenium on renal toxicity in mice.  JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY,      [PMID:40393107] [10.1016/j.jtemb.2025.127671]
19. Man Xiong, Lei Yang, Xinfang Liu, Sidong Luo, Yeyang Wang.  (2025)  Circumferentially Aligned Electrospun Vascular Grafts Improves Its Vascular Regeneration and Remodeling in vivo.  International Journal of Nanomedicine,      [PMID:40535837] [10.2147/IJN.S518283]
20. Ziyang Wang, Qinqin Ouyang, Xiaolin Liang, Hongxia Li, Haiying Guo, Rong Liu.  (2025)  Morus alba L. Polysaccharide as an mTORC1-targeting agent against type 2 diabetes.  Journal of Agriculture and Food Research,      [PMID:] [10.1016/j.jafr.2025.102411]
21. Jeng-Yuan Yao, De-Tian-Yu Tzeng, Cai-Hong Feng, Gong-Man Xiao, Tian-Ni You, Ru-Yu Zheng.  (2025)  Leucine supplementation modulates lipid metabolism and metabolic pathways in mice with type 1 diabetes: A metabolomics study.  Experimental and Therapeutic Medicine,  31  (1): (1-8).  [PMID:41282461] [10.3892/etm.2025.13012]
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23. Xiaoping Guo, Chao Wang, Xin Yu, Shanshan Zhang, Haoyu Zheng, Tianqi Liu, Zhili Chen, Guoqiang Wang, Fang Wang.  (2025)  Cold Exposure Exacerbates Allergic Airway Inflammation via Ferroptosis: Evidence from a Murine Model.  Antioxidants,  15  (1): (32).  [PMID:41596091] [10.3390/antiox15010032]
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