2′-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid sodium salt hydrate, CAS No.76204-02-9

CAS: 76204-02-9 Cat. No.: M755481 Molecular Weight: 489.41(anhydrous basis)

GRADE & PURITY BioReagent, for Fluorescence analysis, ≥96.5%(HPLC)

Overview

2′-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid or 4-MUNANA is a synthetic fluorometric substrate that mimics the naturally occurring neuraminidase enzyme substrate. The enzyme-substrate hydrolysis results in the product 4-methylumbelliferone (4-MU), measured fluorometrically.

Application:

2′-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid or 4-MUNANA is used as a substrate for the development of a microplate-based assay for neuraminidase inhibitors. The fluorogenic substrate 2ʹ-(4-methylumbelliferyl)-α-D-N-acetylneuraminic acid (4-MUNANA) is used to study the molecular mechanisms of aspirin and celecoxib targeting mammalian neuraminidase-1.

Specifications

Product Name

2′-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid sodium salt hydrate, CAS No.76204-02-9

Grade

BioReagent, for Fluorescence analysis

Specifications & Purity

BioReagent, for fluorescence analysis, ≥96.5%(HPLC)

Biochemical and Physiological Mechanisms

Substrate for fluorometric assay of neuraminidase. Used for fluorescent staining of sialidases in PAGE.

CAS

76204-02-9

Molecule Type

Small molecule

Storage and Shipping

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Class Coumarins and derivatives
      • Subclass Coumarin glycosides

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Class: Coumarins and derivatives
• Subclass: Coumarin glycosides
• Intermediate Tree Nodes: Not available
• Direct Parent: Coumarin glycosides
• Alternative Parents: N-acylneuraminic acids Neuraminic acids C-glucuronides Phenoxyacetic acid derivatives C-glycosyl compounds 1-benzopyrans Pyranones and derivatives Ketals Oxanes Acetamides Heteroaromatic compounds Secondary carboxylic acid amides Secondary alcohols Carboxylic acid salts Lactones Polyols Oxacyclic compounds Carboxylic acids Monocarboxylic acids and derivatives Organic zwitterions Primary alcohols Organonitrogen compounds Carbonyl compounds Hydrocarbon derivatives Organic sodium salts Organic oxides Organopnictogen compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Coumarin-7-o-glycoside - Coumarin o-glycoside - N-acylneuraminic acid - N-acylneuraminic acid or derivatives - Neuraminic acid - C-glucuronide - C-glycosyl compound - Phenoxyacetate - Glycosyl compound - Benzopyran - 1-benzopyran - Ketal - Pyranone - Pyran - Benzenoid - Oxane - Heteroaromatic compound - Acetamide - Secondary carboxylic acid amide - Secondary alcohol - Carboxamide group - Carboxylic acid salt - Lactone - Acetal - Carboxylic acid derivative - Carboxylic acid - Oxacycle - Organic alkali metal salt - Organoheterocyclic compound - Monocarboxylic acid or derivatives - Polyol - Organic sodium salt - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Alcohol - Organopnictogen compound - Carbonyl group - Organic salt - Organonitrogen compound - Organooxygen compound - Organic zwitterion - Primary alcohol - Organic oxide - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as coumarin glycosides. These are aromatic compounds containing a carbohydrate moiety glycosidically bound to a coumarin moiety.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y