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· · COA & SDS available for every product · Same-day shipping on in-stock items 2-PMPA - ≥98%(HPLC) , CAS No.173039-10-6
Synonyms
HMS3412K10 | HMS3676K10 | HY-100788 | 2-PMPA, >=98% (HPLC) | PMPA(NAALADaseinhibitor) | Pentanedioic acid, 2-(phosphonomethyl)- | UNII-XH88WJG9LJ | AKOS016004257 | HMS3749M13 | HMS3267D10 | (R,S)-2-phosphonomethylpentanedioic acid | YGA03910 | SCHEMBL3831
Storage
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
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Why this grade ≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Synonyms
HMS3412K10 | HMS3676K10 | HY-100788 | 2-PMPA, >=98% (HPLC) | PMPA(NAALADaseinhibitor) | Pentanedioic acid, 2-(phosphonomethyl)- | UNII-XH88WJG9LJ | AKOS016004257 | HMS3749M13 | HMS3267D10 | (R, S)-2-phosphonomethylpentanedioic acid | YGA03910 | SCHEMBL3831
Specifications & Purity
≥98%(HPLC)
Biochemical and Physiological Mechanisms
2-PMPA 是一种有效的（IC50 ~ 1 nM）选择性谷氨酸羧肽酶 II（GCPII）抑制剂，也称为 N-乙酰基-L-天冬氨酰-L-谷氨酸肽酶 I（NAALADase I）、NAAG 肽酶或前列腺素-特异性膜抗原（PSMA）。2-PMPA 具有神经保护活性。2-PMPA 在多发性硬化症的 EAE 模型中已被证明可预防和治疗认知障碍，并防止梭曼诱导的神经病理学。 2-PMPA 是谷氨酸羧肽酶 II（GCPII）的有效选择性抑制剂。 2-（膦酰基甲基）戊二酸（2-PMPA）阻断由低单位剂量的可卡因维持的静
Storage
Store at -20°C, Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers Pubchem Sid 504765270 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504765270 Canonical Smiles C(CC(=O)O)C(CP(=O)(O)O)C(=O)O IUPAC Name 2-(phosphonomethyl)pentanedioic acid InChIKey ISEYJGQFXSTPMQ-UHFFFAOYSA-N INCHI 1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13) Isomeric SMILES C(CC(=O)O)C(CP(=O)(O)O)C(=O)O RTECS SA0454800 PubChem CID 10130754 Molecular Weight 226.12
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organic acids and derivatives Class Carboxylic acids and derivatives Subclass Dicarboxylic acids and derivatives Intermediate Tree Nodes Not available Direct Parent Dicarboxylic acids and derivatives Alternative Parents Fatty acids and conjugates Organic phosphonic acids Carboxylic acids Organophosphorus compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds Molecular Framework Aliphatic acyclic compounds Substituents Fatty acid - Dicarboxylic acid or derivatives - Organophosphonic acid derivative - Organophosphonic acid - Carboxylic acid - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organophosphorus compound - Organooxygen compound - Carbonyl group - Aliphatic acyclic compound Description This compound belongs to the class of organic compounds known as dicarboxylic acids and derivatives. These are organic compounds containing exactly two carboxylic acid groups. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Soluble to 100 mM in sterile water Sensitivity Moisture sensitive Molecular Weight 226.120 g/mol XLogP3 -2.200 Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 7 Rotatable Bond Count 6 Exact Mass 226.024 Da Monoisotopic Mass 226.024 Da Topological Polar Surface Area 132.000 Ų Heavy Atom Count 14 Formal Charge 0 Complexity 267.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 1 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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