2-PMPA - ≥98%(HPLC) , CAS No.173039-10-6

CAS: 173039-10-6 Cat. No.: P167889 Summenformel: C₆H₁₁O₇P Molekulargewicht: 226.12 EG-Nummer: 998-881-8 PubChem CID: 10130754

GRADE & PURITY ≥98%(HPLC)

Synonyms

HMS3412K10 | HMS3676K10 | HY-100788 | 2-PMPA, >=98% (HPLC) | PMPA(NAALADaseinhibitor) | Pentanedioic acid, 2-(phosphonomethyl)- | UNII-XH88WJG9LJ | AKOS016004257 | HMS3749M13 | HMS3267D10 | (R,S)-2-phosphonomethylpentanedioic acid | YGA03910 | SCHEMBL3831

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Specifications

Synonyme

HMS3412K10 | HMS3676K10 | HY-100788 | 2-PMPA, >=98% (HPLC) | PMPA(NAALADaseinhibitor) | Pentanedioic acid, 2-(phosphonomethyl)- | UNII-XH88WJG9LJ | AKOS016004257 | HMS3749M13 | HMS3267D10 | (R,S)-2-phosphonomethylpentanedioic acid | YGA03910 | SCHEMBL3831

Spezifikationen & Reinheit

≥98%(HPLC)

Biochemische und physiologische Mechanismen

2-PMPA 是一种有效的（IC50 ~ 1 nM）选择性谷氨酸羧肽酶 II（GCPII）抑制剂，也称为 N-乙酰基-L-天冬氨酰-L-谷氨酸肽酶 I（NAALADase I）、NAAG 肽酶或前列腺素-特异性膜抗原（PSMA）。2-PMPA 具有神经保护活性。2-PMPA 在多发性硬化症的 EAE 模型中已被证明可预防和治疗认知障碍，并防止梭曼诱导的神经病理学。 2-PMPA 是谷氨酸羧肽酶 II（GCPII）的有效选择性抑制剂。 2-（膦酰基甲基）戊二酸（2-PMPA）阻断由低单位剂量的可卡因维持的静

Storage

Store at -20°C,Argon charged

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Reinheit

≥98%(HPLC)

Namen und Kennungen

• Pubchem Sid: 504765270
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504765270
• Kanonisches Lächeln: C(CC(=O)O)C(CP(=O)(O)O)C(=O)O
• IUPAC Name: 2-(phosphonomethyl)pentanedioic acid
• InChIKey: ISEYJGQFXSTPMQ-UHFFFAOYSA-N
• INCHI: 1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13)
• Isomere SMILES: C(CC(=O)O)C(CP(=O)(O)O)C(=O)O
• RTECS: SA0454800
• PubChem CID: 10130754
• Molekulargewicht: 226.12

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Klasse Carboxylic acids and derivatives
      • Subclass Dicarboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Klasse: Carboxylic acids and derivatives
• Subclass: Dicarboxylic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Dicarboxylic acids and derivatives
• Alternative Parents: Fatty acids and conjugates Organic phosphonic acids Carboxylic acids Organophosphorus compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Fatty acid - Dicarboxylic acid or derivatives - Organophosphonic acid derivative - Organophosphonic acid - Carboxylic acid - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organophosphorus compound - Organooxygen compound - Carbonyl group - Aliphatic acyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as dicarboxylic acids and derivatives. These are organic compounds containing exactly two carboxylic acid groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Soluble to 100 mM in sterile water
• Empfindlichkeit: Moisture sensitive
• Molekulargewicht: 226.120 g/mol
• XLogP3: -2.200
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 6
• Exact Mass: 226.024 Da
• Monoisotopic Mass: 226.024 Da
• Topological Polar Surface Area: 132.000 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 267.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1