4,4′-(Hexafluoroisopropylidene)bis(p-phenyleneoxy)dianiline(HFBAPP) - Moligand™, ≥97% , Activator of K 2P10.1;Activator of K 2P2.1, CAS No.69563-88-8, Activator of K 2P10.1;Activator of K 2P2.1

CAS: 69563-88-8 Cat. No.: H102221 Molecular Weight: 518.45 EC Number: 626-703-8

GRADE & PURITY Moligand™, ≥97%

Synonyms

4,4'-(Hexafluoroisopropylidene)bis(p-phenyleneoxy)dianiline | GI-530159 | 2,2-Bis[4-(4-aminophenoxy)phenyl]hexafluoropropane | 4,4'-(Hexafluoroisopropylidene)bis[(4-aminophenoxy)benzene]

Storage

Room temperature

Shipped In

Normal

Specifications

Synonyms

4, 4'-(Hexafluoroisopropylidene)bis(p-phenyleneoxy)dianiline | GI-530159 | 2, 2-Bis[4-(4-aminophenoxy)phenyl]hexafluoropropane | 4, 4'-(Hexafluoroisopropylidene)bis[(4-aminophenoxy)benzene]

Specifications & Purity

Moligand™, ≥97%

Biochemical and Physiological Mechanisms

TREK1 and TREK2 channel activator (EC50= 0.76 μM in Rb efflux assay in TREK1-expressing CHO cells). Exhibits selectivity for TREK1/2 over TRAAK, TASK3 and a range of other potassium channels. Hyperpolarizes membrane potential of dorsal root ganglion neuro

Storage

Room temperature

Shipped In

Normal

Grade

Moligand™

Action Type

ACTIVATOR

Mechanism of action

Activator of K 2P10.1;Activator of K 2P2.1

Purity

≥97%

Names and Identifiers

• Pubchem Sid: 488186850
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488186850
• Canonical Smiles: C1=CC(=CC=C1C(C2=CC=C(C=C2)OC3=CC=C(C=C3)N)(C(F)(F)F)C(F)(F)F)OC4=CC=C(C=C4)N
• IUPAC Name: 4-[4-[2-[4-(4-aminophenoxy)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-yl]phenoxy]aniline
• InChIKey: HHLMWQDRYZAENA-UHFFFAOYSA-N
• INCHI: 1S/C27H20F6N2O2/c28-26(29,30)25(27(31,32)33,17-1-9-21(10-2-17)36-23-13-5-19(34)6-14-23)18-3-11-22(12-4-18)37-24-15-7-20(35)8-16-24/h1-16H,34-35H2
• Isomeric SMILES: C1=CC(=CC=C1C(C2=CC=C(C=C2)OC3=CC=C(C=C3)N)(C(F)(F)F)C(F)(F)F)OC4=CC=C(C=C4)N
• WGK Germany: 3
• RTECS: CY1213000
• Molecular Weight: 518.45
• Reaxy-Rn: 8879443
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8879443&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Diphenylmethanes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Diphenylmethanes
• Intermediate Tree Nodes: Not available
• Direct Parent: Diphenylmethanes
• Alternative Parents: Diphenylethers Diarylethers Phenoxy compounds Phenol ethers Aniline and substituted anilines Primary amines Organopnictogen compounds Organofluorides Hydrocarbon derivatives Alkyl fluorides
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Diphenylmethane - Diphenylether - Diaryl ether - Phenoxy compound - Phenol ether - Aniline or substituted anilines - Ether - Amine - Primary amine - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Alkyl fluoride - Organic oxygen compound - Hydrocarbon derivative - Alkyl halide - Organopnictogen compound - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

KCNK2 Tclin Potassium channel subfamily K member 2 (2 Activities)

Discover Target: KCNK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNK10 Tclin Potassium channel subfamily K member 10 (0 Activities)

Discover Target: KCNK10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Insoluble in water, soluble in methanol
• Melt Point(°C): 159-163°C
• Molecular Weight: 518.400 g/mol
• XLogP3: 7.600
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 6
• Exact Mass: 518.143 Da
• Monoisotopic Mass: 518.143 Da
• Topological Polar Surface Area: 70.500 Ų
• Heavy Atom Count: 37
• Formal Charge: 0
• Complexity: 641.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Lidong Cao, Yaqing Wen, Xingzhong Fang, Guofei Chen.  (2023)  Synthesis of highly thermoplastic polyamide-imides with high transparency and low coefficient of thermal expansion.  POLYMER,      [PMID:] [10.1016/j.polymer.2023.126093]

2. Chaoying Liao, Zhaozhu Zhang, Yaohui He, Junya Yuan, Mingming Yang, Peilong Li, Wei Jiang, Yongmin Liang, Weimin Liu.  (2025)  Bioinspired Antiwear Poly(urea-imide) Composites: Influence of Tribology on Polymer Crystal Structure.  Small,      [PMID:39780741] [10.1002/smll.202408249]

3. Chaoying Liao, Zhaozhu Zhang, Yaohui He, Mingming Yang, Junya Yuan, Peilong Li, Yongmin Liang.  (2025)  Liquid metal microcapsules induced formation of dual-layer tribofilm for enhanced wear resistance in fabric composites.  TRIBOLOGY INTERNATIONAL,      [PMID:] [10.1016/j.triboint.2025.110598]