4,4′-Methylene-bis(2-chloroaniline) - ≥98% , CAS No.101-14-4

CAS: 101-14-4 Cat. No.: M121680 Molecular Weight: 267.15 Beilstein Registry Number: 1882318 EC Number: 202-918-9
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Synonyms
3,4'-diaminodifenilmetano | Methylenebis(3-chloro-4-aminobenzene) | methylenebis(o-chloroaniline) | 3L2W5VTT2A | 4,4'-Methylene(bis)-chloroaniline | Benzenamine, ar,ar'-methylenebis(2-chloro- | HMS3039N14 | 4,4-Metilene-bis-o-cloroanilina [Italian] | 4,4'
Storage
Room temperature
Shipped In
FedEx DG Service
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
25g
M121680-25g
1
$9.90
100g
M121680-100g
4
$29.90
500g
M121680-500g
3
$109.90
Enter a quantity for the sizes you want to add.
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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Room temperature Ships FedEx DG Service Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 13 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
3, 4'-diaminodifenilmetano | Methylenebis(3-chloro-4-aminobenzene) | methylenebis(o-chloroaniline) | 3L2W5VTT2A | 4, 4'-Methylene(bis)-chloroaniline | Benzenamine, ar, ar'-methylenebis(2-chloro- | HMS3039N14 | 4, 4-Metilene-bis-o-cloroanilina [Italian] | 4, 4'
Specifications & Purity
≥98%
Storage
Room temperature
Shipped In
FedEx DG Service
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥98%
Names and Identifiers
Pubchem Sid488180477
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488180477
Canonical SmilesC1=CC(=C(C=C1CC2=CC(=C(C=C2)N)Cl)Cl)N
IUPAC Name4-[(4-amino-3-chlorophenyl)methyl]-2-chloroaniline
InChIKeyIBOFVQJTBBUKMU-UHFFFAOYSA-N
INCHI1S/C13H12Cl2N2/c14-10-6-8(1-3-12(10)16)5-9-2-4-13(17)11(15)7-9/h1-4,6-7H,5,16-17H2
Isomeric SMILES C1=CC(=C(C=C1CC2=CC(=C(C=C2)N)Cl)Cl)N
WGK Germany 3
UN Number 3077
Packing Group III
Molecular Weight 267.15
Beilstein 1882318
Reaxy-Rn 1882318
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1882318&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClassBenzene and substituted derivatives
SubclassDiphenylmethanes
Intermediate Tree Nodes Not available
Direct ParentDiphenylmethanes
Alternative Parents Aniline and substituted anilines  Chlorobenzenes  Aryl chlorides  Primary amines  Organopnictogen compounds  Organochlorides  Hydrocarbon derivatives  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents Diphenylmethane - Aniline or substituted anilines - Halobenzene - Chlorobenzene - Aryl halide - Aryl chloride - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Primary amine - Organonitrogen compound - Organochloride - Organohalogen compound - Amine - Aromatic homomonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
External Descriptors chloroaniline
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RXRA Tclin Retinoid X receptor alpha (3637 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CXCL8 Tchem Interleukin-8 (642 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SNCA Tchem Alpha-synuclein (10960 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
lef Anthrax lethal factor (7585 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nr1i2 Nuclear receptor subfamily 1 group I member 2 (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

13 results found

Lot NumberCertificate TypeDateItem
H2209689Certificate of AnalysisMay 20, 2026 M121680
H2209690Certificate of AnalysisMay 20, 2026 M121680
E2614172Certificate of AnalysisMay 12, 2026 M121680
E2614173Certificate of AnalysisMay 12, 2026 M121680
L2107615Certificate of AnalysisSep 09, 2025 M121680
L2107830Certificate of AnalysisSep 09, 2025 M121680
F2512361Certificate of AnalysisMay 26, 2025 M121680
F2512362Certificate of AnalysisMay 26, 2025 M121680
F2512368Certificate of AnalysisMay 26, 2025 M121680
H1914187Certificate of AnalysisJun 05, 2023 M121680
B2307044Certificate of AnalysisJun 29, 2022 M121680
E1809117Certificate of AnalysisMar 31, 2022 M121680
B2307089Certificate of AnalysisJul 28, 2021 M121680

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Chemical and Physical Properties
Flash Point(°C)113°C
Boil Point(°C)202-214°C
Melt Point(°C)102-107°C
Molecular Weight267.150 g/mol
XLogP33.800
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass266.038 Da
Monoisotopic Mass266.038 Da
Topological Polar Surface Area52.000 Ų
Heavy Atom Count17
Formal Charge0
Complexity226.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Lijing Lu, Haoyue Ning, Jipeng Guo, Chuang Guo, Liao Pan, Lixin Lu.  (2023)  Synthesis, Evaluation, and Electrochemical Detection Application of Magnetic Molecularly Imprinted Polymers for 4,4-Methylenedianiline from Food-Contact Materials.  ADVANCES IN POLYMER TECHNOLOGY,      [PMID:] [10.1155/2023/9306542]
2. Tianhong Yang, Zhaoyi He, Gang Huang, Yongli Zhao, Jianwei Fu, Hao Xiang, Yingju Zhou.  (2023)  Study on materials composition and process parameters of polyurethane-modified asphalt synthesized in-situ by the one-shot process.  CONSTRUCTION AND BUILDING MATERIALS,      [PMID:] [10.1016/j.conbuildmat.2023.130661]
3. Wenxiu Jiao, Aimin Sha, Jin Zhang, Meng Jia, Wei Jiang, Liqun Hu.  (2023)  Design and properties of polyurethane solid–solid phase-change granular temperature regulation asphalt mixtures.  SOLAR ENERGY,      [PMID:] [10.1016/j.solener.2023.02.008]
4. Yanjie Zheng, Keli Wang, Lei Sun, Huili Shi, Xia Zhang.  (2022)  Preparation of PFDTS-kaolin/PU superamphiphobic coatings with antibacterial, antifouling and improved durability property.  PROGRESS IN ORGANIC COATINGS,      [PMID:] [10.1016/j.porgcoat.2022.107145]
5. Yaochen Zheng, Peng Song, Shaoxiang Liu, Mengqing Wu, Hui Xu, Chenghui Qiao, Jian Liu, Zhengguo Gao, Qingfu Ban.  (2021)  Transparent and toughening epoxy thermosets modified by linear telechelic polymer containing rigid spiroacetal moieties: Uncovering the relationship between the heterogeneous crosslinked network and thermoset performances.  JOURNAL OF POLYMER SCIENCE,  59  (13): (1390-1398).  [PMID:] [10.1002/pol.20210178]
6. Xiongwei Wang, Peiyi Wu.  (2019)  3D Vertically Aligned BNNS Network with Long-Range Continuous Channels for Achieving a Highly Thermally Conductive Composite.  ACS Applied Materials & Interfaces,      [PMID:31361947] [10.1021/acsami.9b09398]
7. Ziming Shen, Jiachun Feng.  (2019)  Preparation of Thermally Conductive Polymer Composites with Good Electromagnetic Interference Shielding Efficiency Based on Natural Wood-Derived Carbon Scaffolds.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.8b06661]
8. Ziming Shen, Jiachun Feng.  (2018)  Achieving vertically aligned SiC microwires networks in a uniform cold environment for polymer composites with high through-plane thermal conductivity enhancement.  COMPOSITES SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.compscitech.2018.11.036]
9. Shusheng Chen, Bin Chen, Jiashu Fan, Jiachun Feng.  (2015)  Exploring the Application of Sustainable Poly(propylene carbonate) Copolymer in Toughening Epoxy Thermosets.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.5b00343]
10. Jiading Wang, Shaoyun Guo, Xianlong Zhang.  (2024)  Broken Chain Self-Reconnection Strategy Enables Radiation Ultraresistance of Polyurethane.  MACROMOLECULES,      [PMID:] [10.1021/acs.macromol.4c02557]
11. Meng Jia, Fan Zhang, Aimin Sha, Zhe Li, Wentong Wang, Wenxiu Jiao.  (2025)  Structural control and performance evaluation of polyurethane-based solid–solid phase change materials for thermal regulation of asphalt pavements in high-temperature climate conditions.  Journal of Energy Storage,      [PMID:] [10.1016/j.est.2025.118182]
12. Yan Zhou, Weibo Liu, Yu Feng, Pengfei Shi, Liqiang Wan, Xufeng Hao, Farong Huang, Jianhua Qian, Zuozhen Liu.  (2025)  The Effect of the Structure of Aromatic Diamine on High-Performance Epoxy Resins.  Journal of Composites Science,  (8): (416).  [PMID:] [10.3390/jcs9080416]
13. Jiao Yuchen, Zhou Ming, Pu Bo, Yang Xiaoling, Li Chenyiting, Xia Liangliang, Deng Guilin, Wei Yunyao, Zhong Jing, Wu Zheng, Chen Shi, Wang Jian, Zhou Yujun.  (2026)  Preparation of room-temperature self-healing recyclable polyurethane elastomers based on a multiple hydrogen/nitrogen coordination boro-oxygen bonds system.  JOURNAL OF POLYMER RESEARCH,  33  (3): (114).  [PMID:] [10.1007/s10965-025-04746-w]
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