4-Formylmorpholine - ≥99% , CAS No.4394-85-8

CAS: 4394-85-8 Cat. No.: F111002 Molecular Weight: 115.13 Beilstein Registry Number: 110293 EC Number: 224-518-3
AVAILABLE TO ORDER
GRADE & PURITY ≥99%
Synonyms
D1E63XO4RH | DTXCID5024427 | UNII-D1E63XO4RH | FORMYL MORPHOLINE [INCI] | F0157 | MFCD00006170 | N-Formylmorpholine-13C | 4-Morpholinecarbaldehyde N-Formylmorpholine | Molsidomine Imp. D (EP); Molsidomine Impurity D | N-formyhnorpholine | s12160 | SY00478
Storage
Store at 2-8°C,Argon charged
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
25g
F111002-25g
2
$9.90
100g
F111002-100g
3
$18.90
500g
F111002-500g
10
$33.90
Enter a quantity for the sizes you want to add.
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Why this grade

≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at 2-8°C,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 8 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Treatment of 4-formylmorpholine with sulphur tetrafluoride in the presence of potassium fluoride gives 4-(trifluoromethyl)morpholine in excellent yields. 4-Formylmorpholine reacts with series of 2-alkyl-2-cyclohexen-1-ones in the presence of POCl3 to give the corresponding 3-alkyl-2-chloro-5,6-dihydrobenzaldehydes and allylic alcohols (by-product).
4-Formylmorpholine has been used in the preparation of: ? adenine hydrochloride labelled with 14C ? terphenyl dialdehyde

Specifications

Synonyms
D1E63XO4RH | DTXCID5024427 | UNII-D1E63XO4RH | FORMYL MORPHOLINE [INCI] | F0157 | MFCD00006170 | N-Formylmorpholine-13C | 4-Morpholinecarbaldehyde N-Formylmorpholine | Molsidomine Imp. D (EP); Molsidomine Impurity D | N-formyhnorpholine | s12160 | SY00478
Specifications & Purity
≥99%
Storage
Store at 2-8°C, Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥99%
Names and Identifiers
Pubchem Sid504752979
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504752979
Canonical SmilesC1COCCN1C=O
IUPAC Namemorpholine-4-carbaldehyde
InChIKeyLCEDQNDDFOCWGG-UHFFFAOYSA-N
INCHI1S/C5H9NO2/c7-5-6-1-3-8-4-2-6/h5H,1-4H2
Isomeric SMILES C1COCCN1C=O
WGK Germany 3
RTECS QD9694000
Molecular Weight 115.13
Beilstein 110293
Reaxy-Rn 110293
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=110293&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassOxazinanes
SubclassMorpholines
Intermediate Tree Nodes Not available
Direct ParentMorpholines
Alternative Parents Tertiary carboxylic acid amides  Oxacyclic compounds  Dialkyl ethers  Azacyclic compounds  Organopnictogen compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAliphatic heteromonocyclic compounds
Substituents Morpholine - Tertiary carboxylic acid amide - Carboxamide group - Carboxylic acid derivative - Dialkyl ether - Ether - Oxacycle - Azacycle - Carbonyl group - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aliphatic heteromonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as morpholines. These are organic compounds containing a morpholine moiety, which consists of a six-member aliphatic saturated ring with the formula C4H9NO, where the oxygen and nitrogen atoms lie at positions 1 and 4, respectively.
External Descriptors morpholines
3D Structure
Interactive Chemical Structure Model





Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

13 results found

Lot NumberCertificate TypeDateItem
F2616070Certificate of AnalysisJun 30, 2026 F111002
F2617070Certificate of AnalysisJun 27, 2026 F111002
G2209216Certificate of AnalysisApr 07, 2026 F111002
G2209228Certificate of AnalysisApr 07, 2026 F111002
G2209232Certificate of AnalysisApr 07, 2026 F111002
G2209254Certificate of AnalysisApr 07, 2026 F111002
K2117949Certificate of AnalysisSep 04, 2025 F111002
J1826096Certificate of AnalysisAug 15, 2022 F111002
A2426059Certificate of AnalysisJun 20, 2022 F111002
G2209227Certificate of AnalysisJun 20, 2022 F111002
J2429183Certificate of AnalysisJun 20, 2022 F111002
J2511118Certificate of AnalysisJun 20, 2022 F111002
K2505125Certificate of AnalysisJun 20, 2022 F111002

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Chemical and Physical Properties
SolubilityMiscible with water.
SensitivityMoisture & heat sensitive
Refractive Index1.485
Flash Point(°F)257 °F
Flash Point(°C)125 °C
Boil Point(°C)236-237°C
Melt Point(°C)22-24 °C
Molecular Weight115.130 g/mol
XLogP3-0.600
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass115.063 Da
Monoisotopic Mass115.063 Da
Topological Polar Surface Area29.500 Ų
Heavy Atom Count8
Formal Charge0
Complexity78.500
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Mengjin Zhou, Xiaomin Qiu, Yajuan Qu, Yangyang Liu, Zhaoyou Zhu, Yinglong Wang, Peizhe Cui, Jingwei Yang.  (2023)  Separation mechanism and thermodynamic phase behavior of n-propanol/p-xylene azeotrope from petrochemical wastewater by green solvents.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2023.122156]
2. Guojia Yu, Xiaojia Wu, Lu Wei, Zhiyong Zhou, Wei Liu, Fan Zhang, Yixin Qu, Zhongqi Ren.  (2021)  Desulfurization of diesel fuel by one-pot method with morpholinium-based Brønsted acidic ionic liquid.  FUEL,      [PMID:] [10.1016/j.fuel.2021.120551]
3. Chong Yang, Shimin Xu, Yuyao Xie, Yepeng Xiao, Lihua Cheng, Xinping Ouyang.  (2024)  Liquid–Liquid Equilibrium Data and Mechanism for Separating Thiophene from Heptane Using Mixed Solvents.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,      [PMID:] [10.1021/acs.jced.4c00154]
4. Chong Yang, Shimin Xu, Yuyao Xie, Pai Lu, Hui Wang, Lihua Cheng.  (2024)  Measurement and Correlation of Liquid–Liquid Equilibrium Data for Separating Butyl Acetate from n-Octane Using Various Extractants.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,      [PMID:] [10.1021/acs.jced.4c00331]
5. Xueqi Sun, Shaojuan Zeng, Guilin Li, Yinge Bai, Minghua Shang, Jian Zhang, Xiangping Zhang.  (2024)  Selective CO2 separation through physicochemical absorption by triazole-functionalized ionic liquid binary absorbents.  AICHE JOURNAL,      [PMID:] [10.1002/aic.18376]
6. Yuxin Zhou, Tianhuan Huang, Shaohua Zhong, Xiaoqing Li, Yiwen Chen, Kunyao Su, Weihuang Yang, Jiangrong Lu, Jian Zhang.  (2025)  PVDF-HFP gel polymer electrolytes with a uniform porous network for lithium metal batteries.  JOURNAL OF POWER SOURCES,      [PMID:] [10.1016/j.jpowsour.2025.238207]
7. Jun Li, Wanting Yu, Jinsen Gao.  (2025)  Separation of polycyclic aromatic hydrocarbons by solvent screening assisted extractive distillation from FCC diesel.  CHINESE JOURNAL OF CHEMICAL ENGINEERING,      [PMID:] [10.1016/j.cjche.2025.09.001]
8. Zhongqi Ren, Lu Wei, Zhiyong Zhou, Fan Zhang, Wei Liu.  (2018)  Extractive Desulfurization of Model Oil with Protic Ionic Liquids.  ENERGY & FUELS,      [PMID:] [10.1021/acs.energyfuels.8b01936]
Solution Calculators
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