66% in water for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Room temperature Ships FedEx DG Service Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 8 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
| Pubchem Sid | 504750808 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504750808 |
| Canonical Smiles | C1=CC(=CC=C1O)S(=O)(=O)O |
| IUPAC Name | 4-hydroxybenzenesulfonic acid |
| InChIKey | FEPBITJSIHRMRT-UHFFFAOYSA-N |
| INCHI | 1S/C6H6O4S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4,7H,(H,8,9,10) |
| Isomeric SMILES | C1=CC(=CC=C1O)S(=O)(=O)O |
| WGK Germany | 3 |
| UN Number | 2586 |
| Packing Group | III |
| Molecular Weight | 174.17 |
| Beilstein | 1869034 |
| Reaxy-Rn | 1869034 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1869034&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Benzene and substituted derivatives |
| Subclass | Benzenesulfonic acids and derivatives |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Benzenesulfonic acids and derivatives |
| Alternative Parents | Benzenesulfonyl compounds 1-sulfo,2-unsubstituted aromatic compounds 1-hydroxy-2-unsubstituted benzenoids Sulfonyls Organosulfonic acids Organooxygen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Benzenesulfonate - Arylsulfonic acid or derivatives - 1-sulfo,2-unsubstituted aromatic compound - Benzenesulfonyl group - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Sulfonyl - Organosulfonic acid - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Organic oxygen compound - Organosulfur compound - Organooxygen compound - Organic oxide - Hydrocarbon derivative - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as benzenesulfonic acids and derivatives. These are organic compounds containing a sulfonic acid or a derivative thereof that is linked to a benzene ring. |
| External Descriptors | arenesulfonic acid |
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 H2505054 | Certificate of Analysis | Aug 12, 2025 | H111204 |
| G2419489 | Certificate of Analysis | Jul 12, 2024 | H111204 |
| G2419490 | Certificate of Analysis | Jul 12, 2024 | H111204 |
| G2419491 | Certificate of Analysis | Jul 12, 2024 | H111204 |
| F2429242 | Certificate of Analysis | Jun 21, 2024 | H111204 |
| F2429243 | Certificate of Analysis | Jun 21, 2024 | H111204 |
| I1612045 | Certificate of Analysis | May 09, 2024 | H111204 |
| A1606035 | Certificate of Analysis | Aug 08, 2023 | H111204 |
| H1518065 | Certificate of Analysis | Jun 05, 2023 | H111204 |
| D2117091 | Certificate of Analysis | Apr 25, 2021 | H111204 |
| D2415433 | Certificate of Analysis | Apr 25, 2021 | H111204 |
| Sensitivity | Moisture sensitive |
|---|---|
| Refractive Index | 1.489 |
| Melt Point(°C) | 142 °C |
| Molecular Weight | 174.180 g/mol |
| XLogP3 | 0.200 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 1 |
| Exact Mass | 173.999 Da |
| Monoisotopic Mass | 173.999 Da |
| Topological Polar Surface Area | 83.000 Ų |
| Heavy Atom Count | 11 |
| Formal Charge | 0 |
| Complexity | 207.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Xi Zhao, Lin Chen, Peng-Gang Su, Lin-Xi Xiao, Hai-Bo Zhao, Teng Fu, Xiu-Li Wang, Yu-Zhong Wang. (2023) 4-Hydroxybenzenesulfonic acid triggers rapid preparation of phenolic aerogel composites by ambient pressure drying. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2023.147856] |
| 2. Zhe Wang, Xiaozi Lin, Yuanxing Huang, Luming Ma. (2022) The role of hydroxylation on·OH generation for enhanced ozonation of benzoic acids: Reactivity, ozonation efficiency and radical formation mechanism. JOURNAL OF HAZARDOUS MATERIALS, [PMID:35278955] [10.1016/j.jhazmat.2022.128620] |
| 3. Hongjian Wang, Long Chen, Hao Yang, Meidi Wang, Leixin Yang, Haiyan Du, Chenliang Cao, Yanxiong Ren, Yingzhen Wu, Fusheng Pan, Zhongyi Jiang. (2019) Brønsted acid mediated covalent organic framework membranes for efficient molecular separation. Journal of Materials Chemistry A, 7 (35): (20317-20324). [PMID:] [10.1039/C9TA06924K] |
| 4. Xi Wang, Jingjing Mu, Hairong Yu, Xingbin Lv, Ting Liang, Changjing Cheng. (2024) Calix[6]arene-Functionalized Photonic Hydrogel Biosensor for Naked-Eye Cholesterol Detection Based on Supramolecular Host–Guest Interactions. ACS Sensors, [PMID:39374501] [10.1021/acssensors.4c01068] |
| 5. Xueqiang Shao, Changyu Fu, Yujing Zhang, Jinyi Chen, Jinbei Yang, Zhongliang Yao. (2025) Novel Self-Solidifying Polymeric Ionic Liquid via Phenolic Condensation as Efficient and Reusable Catalyst for Biodiesel Production. Asia-Pacific Journal of Chemical Engineering, [PMID:] [10.1002/apj.70007] |
| 6. Guangpeng Ma, Wenyu Bai, Xinpu Zhou, Di Yu, Yu Luo, Tongtong Gao, Shuang Wang. (2024) Novel sulfonated polyaniline/graphene oxide electrode with high cycling stability for all-solid-state flexible supercapacitors. INTERNATIONAL JOURNAL OF HYDROGEN ENERGY, [PMID:] [10.1016/j.ijhydene.2024.03.326] |
| 7. Yuntong Li, Long Li, Caiying Bo, Lihong Hu, Xiaohui Yang, Yonghong Zhou. (2025) An intrinsic lignin-based flame retardant for phenolic foams: Synthesis and fire safety enhancement. REACTIVE & FUNCTIONAL POLYMERS, [PMID:] [10.1016/j.reactfunctpolym.2025.106376] |
| 8. Xiaodong Zhang, Bohui Xu, Deshuai Xiao, Xinyuan Zhang, Pifu Gong, Zheshuai Lin. (2025) From centrosymmetric CN3H6C6H5SO3 to non-centrosymmetric CN3H6C6H4SO3(OH): Hydroxyl introduced hydrogen bond reconstruction to realize strong second harmonic generation. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 44 (10): (100707). [PMID:] [10.1016/j.cjsc.2025.100707] |
