4-Methylumbelliferyl-α-D-Glucopyranoside - Moligand™, 10 mM in DMSO , CAS No.17833-43-1

CAS: 17833-43-1 Cat. No.: M1496624 Molecular Weight: 338.31 Beilstein Registry Number: 1690776 EC Number: 241-794-0

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Argon charged,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

4-Methylumbelliferyl-α-D-Glucopyranoside (4-Methylumbelliferyl-α-D-Glucose) is a fluorescent substrate for α-glucosidase , which releases the fluorescent moiety 4-methylumbelliferyl (4-MU) upon cleavage. 4-MU has pH-dependent fluorescence excitation activity, with excitation wavelengths of 320 nm at low pH (1.97-6.72) and 360 nm at high pH (7.12-10.3), respectively. The emission wavelength of 4-Methylumbelliferyl-α-D-Glucopyranoside increases with decreasing pH, ranging from 445-455 nm. 4-Methylumbelliferyl-α-D-Glucopyranoside can be used as a biomarker for Fabry and Pompe diseases to quantify α-glucosidase activity in infant blood spot samples.

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Argon charged, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Product Properties

• Excitation and Emision Ranges: λex 316 nm,λem 375 nm (Reaction product);λex 317 nm,λem 374 nm in pH9.0;λex 360 nm,λem 449 nm;λex 365 nm,λem 445 nm in 0.1 M Tris pH 8.0

Names and Identifiers

• Isomeric SMILES: CC1=CC(=O)OC2=C1C=CC(=C2)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O
• WGK Germany: 3
• Molecular Weight: 338.31
• Beilstein: 1690776
• Reaxy-Rn: 24926198
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24926198&ln=

Chemical and Physical Properties

• Refractive Index: n20D1.64 (Predicted)
• Boil Point(°C): 571.9-681.9° C at 760 mmHg (Predicted)
• Melt Point(°C): 210-212°C (lit.)