Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 10 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na + /H + exchanger inhibitor, which decreases the intracellular pH (pH i ) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC 50 s of 3.91 μM and 1.34 μM, respectively .
| Isomeric SMILES | C1CCCN(CC1)C2=NC(=C(N=C2Cl)C(=O)N=C(N)N)N |
|---|---|
| WGK Germany | 3 |
| Alternate CAS | 1428-95-1 |
| MeSH Entry Terms | 3-amino-6-chloro-5-(1-homopiperidyl)-N-(diaminomethylene)pyrazinecarboxamide;5-(N,N-hexamethylene)amiloride;5-HMA;hexamethylene amiloride;hexamethyleneamiloride;HMA-5 |
| Molecular Weight | 311.77 |
| Reaxy-Rn | 8579364 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8579364&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| 1. Yang Gao, Kunming Li, Xiuyan Ren, Guanghui Gao. (2023) Thermochromic Hydrogels with Opaque-Transparent Gradient Transition for Switchable Window and Temperature Monitor. CHEMISTRY-A EUROPEAN JOURNAL, [PMID:37584162] [10.1002/chem.202302147] |
| 2. Xiuhua Sun, Shanshan Pan, Zhiren Guo, Yingxin Cui, Liang Ma, Xiaosong Yu, Taijiang Gui, Shougang Chen, Yan Liu, Changlu Gao. (2023) Synergy effect of bactericidal and antifouling with structure reversion and hydrolysis of cationic amphiphilic copolymer PHMA-b-PCBMAE to zwitterionic copolymer. PROGRESS IN ORGANIC COATINGS, [PMID:] [10.1016/j.porgcoat.2023.107508] |
| 3. Liang YaoYao, Luo Juan, Yang Chenhao, Guo Shuning, Zhang Bowen, Chen Fengqianrui, Su Kairui, Zhang Yulong, Dong Yi, Wang Zhihao, Fu Hongda, Sui Guangchao, Wang Pengchao. (2022) Directed evolution of the PobR allosteric transcription factor to generate a biosensor for 4-hydroxymandelic acid. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 38 (6): (1-10). [PMID:35501522] [10.1007/s11274-022-03286-5] |
| 4. Haiquan Zhang, Zijing Liu, Junping Mai, Ning Wang, Jie Zhong, Xianmin Mai, Nan Zhang. (2021) Super-elastic smart phase change material (SPCM) for thermal energy storage. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2021.128482] |
| 5. Kunming Li, Shengfei Meng, Shan Xia, Xiuyan Ren, Guanghui Gao. (2020) Durable and Controllable Smart Windows Based on Thermochromic Hydrogels. ACS Applied Materials & Interfaces, [PMID:32820627] [10.1021/acsami.0c12710] |
| 6. Li Liu, Xinhe Li, Xiuyan Ren, Guang feng Wu. (2020) Flexible strain sensors with rapid self-healing by multiple hydrogen bonds. POLYMER, [PMID:] [10.1016/j.polymer.2020.122657] |
| 7. Yaxin Hu, Xiaoqin Liang, Dongliang Wu, Bang Yu, Yijia Wang, Yifang Mi, Zhihai Cao, Zujin Zhao. (2019) Towards white-light emission of fluorescent polymeric nanoparticles with a single luminogen possessing AIE and TICT properties. Journal of Materials Chemistry C, 8 (2): (734-741). [PMID:] [10.1039/C9TC05690D] |
| 8. Li Liu, Guangchao Lv, Xiuyan Ren, Xinhe Li, Te Wang, Jingwen Dong, Zeyu Wang, Guangfeng Wu. (2019) Effect of size of latex particles on the mechanical properties of hydrogels reinforced by latex particles. RSC Advances, 9 (26): (14701-14707). [PMID:35516310] [10.1039/C9RA01688K] |
| 9. Zheng Li, Jianding Chen, Guijin Zou, Tongyuan Zhang, Dafu Wei, Xiang Xu, Yong Guan, Anna Zheng. (2019) Anionic living polymerization of alkyl methacrylate at ambient temperature and its mechanism research. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 57 (10): (1130-1139). [PMID:] [10.1002/pola.29368] |
| 10. Mingfu Li, Pingjun Zhang, Shuanglan Hu, Douyong Min, Jingjie Tang, Yingchuan Zhang, Liqun Jiang. (2025) Efficient synthesis of 5-hydroxylmethxylfufrual from fructose in a phenolic acid-derived ternary deep eutectic solvent. FUEL, [PMID:] [10.1016/j.fuel.2025.134548] |
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