Adefovir Dipivoxil (GS 0840) - Moligand™,10mM in DMSO , CAS No.142340-99-6

CAS: 142340-99-6 Cat. No.: A409177 Molecular Weight: 501.47 EC Number: 634-317-6

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

1,​1'-​[[[[2-​(6-​amino-​9H-​purin-​9-​yl)​ethoxy]​methyl]​phosphinylidene]​bis(oxymethylene)​]-2,​2-​dimethyl-propanoic acid ester

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Adefovir Dipivoxil (GS 0840) Adefovir Dipivoxil (GS 0840) is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).
In vitro

In vivo

Adefovir Dipivoxil reduces Liver HBV DNA to <0.1 pg of viral DNA per mg of total DNA (pg/mg) in transgenic mice expressing hepatitis B virus. Adefovir Dipivoxil treatment also reduces serum HBV DNA to 3.5 log10 genomic equivalents (ge)/mL in transgenic mice expressing hepatitis B virus compared to 5.3 log10 ge/mL for the placebo control group. Adefovir Dipivoxil antiviral activity reaches near maximum viral reduction by day 10 in the liver and reaches an endpoint of liver virus inhibition at 1.0 mg/kg/day.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

1, ​1'-​[[[[2-​(6-​amino-​9H-​purin-​9-​yl)​ethoxy]​methyl]​phosphinylidene]​bis(oxymethylene)​]-2, ​2-​dimethyl-propanoic acid ester

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Adefovir Dipivoxil (GS 0840) is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Product Properties

• ALogP: 1.8

Names and Identifiers

• Isomeric SMILES: CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C(N=CN=C21)N)OCOC(=O)C(C)(C)C
• WGK Germany: 3
• RTECS: UA2459362
• Molecular Weight: 501.47
• Reaxy-Rn: 7060608
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7060608&ln=

Chemical and Physical Properties

• Melt Point(°C): 101 °C

References

1. Yuehua Yu, Zixuan Li, Yuan He, Ji Huang, Zhenxiao Sun.  (2026)  Repositioning of nonsedating antihistamine Ebastine for anti-lung adenocarcinoma based on EGFR/ERBB2 dual-targeting strategy.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:] [10.1016/j.ejphar.2026.178774]