Angeli′s salt - ≥99% , CAS No.13826-64-7

CAS: 13826-64-7 Cat. No.: A332354 Molecular Weight: 121.99

GRADE & PURITY ≥99%

Synonyms

Sodium trioxodinitrate | Sodium alpha-Oxyhyponitrite | DTXSID20435916 | disodium;N-oxonitramide | disodium diazen-1-ium-1,2,2-triolate | Sodium α-oxyhyponitrite

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

A nitroxyl anion (NO–) donor that spontaneously dissociates in a pH dependent first order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t½) in 100 mM phosphate buffer, pH 7.4 is 2.3 minutes at 37°C. Decomposition is nearly instantaneous at pH 5.0.

A nitroxyl anion (NO-) donor that spontaneously, in the presence of oxygen and Cu2+ and Fe3+, dissociates in a pH-dependent, first-order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t½) of NO release = 2.3 min. (in 100 mM phosphate buffer, pH 7.4 at 37°C). Induces relaxation of norepinephrine-constricted rabbit aorta (EC50 = 590 nM). Angeli′s Salt produces nitroxyl anion (NO-) that can be converted to NO in the presence of heme.

Specifications

Synonyms

Sodium trioxodinitrate | Sodium alpha-Oxyhyponitrite | DTXSID20435916 | disodium;N-oxonitramide | disodium diazen-1-ium-1, 2, 2-triolate | Sodium α-oxyhyponitrite

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Cell permeable: no Primary Target Nitroxyl anion (NO-) donor Product does not compete with ATP. Reversible: no

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Pubchem Sid: 504765262
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504765262
• Isomeric SMILES: N(=O)[N+](=O)[O-].[Na+].[Na+]
• Molecular Weight: 121.99
• Reaxy-Rn: 24894373
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24894373&ln=

Chemical and Physical Properties

• Solubility: H20: 50 mg/ml；PBS (pH 7.2): 50 mg/ml
• Sensitivity: air &moisture sensitive

References

1. Wanying Li, Bingqing Fang, Ming Jin, Yang Tian.  (2017)  Two-Photon Ratiometric Fluorescence Probe with Enhanced Absorption Cross Section for Imaging and Biosensing of Zinc Ions in Hippocampal Tissue and Zebrafish.  ANALYTICAL CHEMISTRY,      [PMID:28192925] [10.1021/acs.analchem.6b04781]

2. Gao Yang, Luo Mingdu, Wang Hongmiao, Zhou Zhiwei, Yin Yandong, Wang Ruohong, Xing Beizi, Yang Xiaohua, Cai Yuping, Zhu Zheng-Jiang.  (2025)  Charting unknown metabolic reactions by mass spectrometry-resolved stable-isotope tracing metabolomics.  Nature Communications,  16  (1): (1-16).  [PMID:40450004] [10.1038/s41467-025-60258-7]