BTYNB - ≥96% , CAS No.304456-62-0

CAS: 304456-62-0 Cat. No.: B414500 Molecular Weight: 309.18

GRADE & PURITY ≥96%

Synonyms

BTYNB IMP1 Inhibitor | MDK6620 | enzamide,2-​[[(5-​bromo-​2-​thienyl)​methylene]​amino]​-

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Information

BTYNB BTYNB (BTYNB IMP1 Inhibitor, MDK6620) is a potent and selective inhibitor of IMP1 binding to c-Myc mRNA. BTYNB downregulates β-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa B (NF-κB) . BTYNB disrupts this enhancer function by impairing IGF2 mRNA-binding protein 1 (IGF2BP1)-RNA association.

Targets

IMP1 ; c-Myc ; NF-κB

In vitro

In cells, BTYNB downregulates several mRNA transcripts regulated by IMP1. BTYNB destabilizes c-Myc mRNA, resulting in downregulation of c-Myc mRNA and protein. BTYNB downregulates β-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa B (NF-κB). The oncogenic translation regulator, eEF2, emerges as a new IMP1 target mRNA, enabling BTYNB to inhibit tumor cell protein synthesis. BTYNB potently inhibits proliferation of IMP1-containing ovarian cancer and melanoma cells with no effect in IMP1-negative cells. Overexpression of IMP1 reverses BTYNB inhibition of cell proliferation. BTYNB completely blocks anchorage-independent growth of melanoma and ovarian cancer cells in colony formation assays.

Cell Research(from reference)

Cell lines：SK-MEL2 cells 

Concentrations：10 μM 

Incubation Time：24 h 

Specifications

Synonyms

BTYNB IMP1 Inhibitor | MDK6620 | enzamide, 2-​[[(5-​bromo-​2-​thienyl)​methylene]​amino]​-

Specifications & Purity

≥96%

Biochemical and Physiological Mechanisms

BTYNB (BTYNB IMP1 Inhibitor, MDK6620) is a potent and selective inhibitor of IMP1 binding to c-Myc mRNA. BTYNB downregulates β-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa B (NF-κB). BTYNB disrupts this enhancer function by i

Storage

Protected from light, Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥96%

Names and Identifiers

• Pubchem Sid: 504759985
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504759985
• Canonical Smiles: C1=CC=C(C(=C1)C(=O)N)N=CC2=CC=C(S2)Br
• IUPAC Name: 2-[(5-bromothiophen-2-yl)methylideneamino]benzamide
• InChIKey: OZEADOPONHLEDS-UHFFFAOYSA-N
• INCHI: 1S/C12H9BrN2OS/c13-11-6-5-8(17-11)7-15-10-4-2-1-3-9(10)12(14)16/h1-7H,(H2,14,16)
• Isomeric SMILES: C1=CC=C(C(=C1)C(=O)N)N=CC2=CC=C(S2)Br
• Molecular Weight: 309.18
• Reaxy-Rn: 29812337
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29812337&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Benzoic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Benzoic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzamides
• Alternative Parents: Benzoyl derivatives 2,5-disubstituted thiophenes Aryl bromides Heteroaromatic compounds Shiff bases Primary carboxylic acid amides Propargyl-type 1,3-dipolar organic compounds Organooxygen compounds Organobromides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Benzamide - Benzoyl - 2,5-disubstituted thiophene - Aryl bromide - Aryl halide - Heteroaromatic compound - Thiophene - Carboxamide group - Primary carboxylic acid amide - Shiff base - Aldimine - Organoheterocyclic compound - Carboxylic acid derivative - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organohalogen compound - Imine - Organic nitrogen compound - Hydrocarbon derivative - Organobromide - Organonitrogen compound - Organooxygen compound - Organic oxygen compound - Organic oxide - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as benzamides. These are organic compounds containing a carboxamido substituent attached to a benzene ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 62 mg/mL (200.53 mM); Ethanol: 4 mg/mL (12.93 mM); Water: Insoluble
• Sensitivity: Light sensitive
• Molecular Weight: 309.180 g/mol
• XLogP3: 3.100
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 307.962 Da
• Monoisotopic Mass: 307.962 Da
• Topological Polar Surface Area: 83.700 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 311.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1