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· · COA & SDS available for every product · Same-day shipping on in-stock items BX517 - Moligand™,≥98% , CAS No.850717-64-5
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98% Synonyms
SB70061 | PDK1 inhibitor 2 | Q27289467 | MS-24008 | BX517(PDK1 inhibitor2) | [(3Z)-2-oxo-3-[1-(1H-pyrrol-2-yl)ethylidene]-2,3-dihydro-1H-indol-5-yl]urea | AKOS032945106 | F85475 | PDK1 inhibitor2 | STK450411 | Urea, N-(2,3-dihydro-2-oxo-3-(1-(1H-pyrrol-2-
Shipped In
Ice chest + Ice pads
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Why this grade Moligand™,≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview Information
BX517 BX517 is a potent and selective inhibitor of PDK1 that binds to the ATP binding pocket of the protein (IC50 = 6 nM).
Targets
cAKT2 ; PDX1 5 nM; 6 nM
In vitro
BX-517 blocks activation of Akt in tumor cells.
In vivo
BX517 has poor pharmaceutical properties including short half-life (0.4 h in rat), low metabolic stability, and poor solubility.
Specifications Synonyms
SB70061 | PDK1 inhibitor 2 | Q27289467 | MS-24008 | BX517(PDK1 inhibitor2) | [(3Z)-2-oxo-3-[1-(1H-pyrrol-2-yl)ethylidene]-2, 3-dihydro-1H-indol-5-yl]urea | AKOS032945106 | F85475 | PDK1 inhibitor2 | STK450411 | Urea, N-(2, 3-dihydro-2-oxo-3-(1-(1H-pyrrol-2-
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
BX517 is a potent and selective inhibitor of PDK1 that binds to the ATP binding pocket of the protein (IC50 = 6 nM).
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers Canonical Smiles CC(=C1C2=C(C=CC(=C2)NC(=O)N)NC1=O)C3=CC=CN3 IUPAC Name [(3Z)-2-oxo-3-[1-(1H-pyrrol-2-yl)ethylidene]-1H-indol-5-yl]urea InChIKey DFURSNCTQGJRRX-JYRVWZFOSA-N INCHI 1S/C15H14N4O2/c1-8(11-3-2-6-17-11)13-10-7-9(18-15(16)21)4-5-12(10)19-14(13)20/h2-7,17H,1H3,(H,19,20)(H3,16,18,21)/b13-8- Isomeric SMILES C/C(=C/1\C2=C(C=CC(=C2)NC(=O)N)NC1=O)/C3=CC=CN3 Molecular Weight 282.30 Reaxy-Rn 11692363 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11692363&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Class Indoles and derivatives Subclass Indolines Intermediate Tree Nodes Not available Direct Parent Indolines Alternative Parents Substituted pyrroles Benzenoids Heteroaromatic compounds Ureas Secondary carboxylic acid amides Lactams Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds Molecular Framework Aromatic heteropolycyclic compounds Substituents Dihydroindole - Substituted pyrrole - Benzenoid - Pyrrole - Heteroaromatic compound - Carboxamide group - Lactam - Secondary carboxylic acid amide - Urea - Carboxylic acid derivative - Azacycle - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Carbonyl group - Organic nitrogen compound - Organic oxide - Hydrocarbon derivative - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as indolines. These are compounds containing an indole moiety, which consists of pyrrolidine ring fused to benzene to form 2,3-dihydroindole. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 56 mg/mL (198.37 mM); Water: Insoluble; Ethanol: Insoluble; Molecular Weight 282.300 g/mol XLogP3 0.900 Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 2 Rotatable Bond Count 2 Exact Mass 282.112 Da Monoisotopic Mass 282.112 Da Topological Polar Surface Area 100.000 Ų Heavy Atom Count 21 Formal Charge 0 Complexity 488.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 1 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 1 Covalently-Bonded Unit Count 1
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