Derivatization Reagents

Explore derivatization reagents that improve analyte detection, separation, or stability in analytical workflows. These products support sample preparation and method development for instrumental analysis.

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  1. 1,3-Cyclohexanedione
    CAS: 504-02-9 EC Number: 207-980-0 Formula: C6H8O2 Molecular Weight: 112.13
    In Stock Item #: C106972
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    Technical Identifiers
    IUPAC Name
    cyclohexane-1,3-dione
    SMILES
    C1CC(=O)CC(=O)C1
    InChIKey
    HJSLFCCWAKVHIW-UHFFFAOYSA-N
    InChI
    1S/C6H8O2/c7-5-2-1-3-6(8)4-5/h1-4H2
    Synonyms
    F0001-1313 | Hydroresorcinol | NSC57477 | NSC-57477 | EC 207-980-0 | 6UK3D2BXJT | STL145900 | UNII-6UK3D2BXJT | BDBM2...
  2. Succinimidyl 4-[3,5-Dimethyl-4-(4-nitrobenzyloxy)phenyl]-4-oxobutyrate
    CAS: 948995-62-8 PubChem CID: 17751994 Formula: C23H22N2O8 Molecular Weight: 454.44
    Out of Stock Item #: S161011
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    IUPAC Name
    (2,5-dioxopyrrolidin-1-yl) 4-[3,5-dimethyl-4-[(4-nitrophenyl)methoxy]phenyl]-4-oxobutanoate
    SMILES
    CC1=CC(=CC(=C1OCC2=CC=C(C=C2)[N+](=O)[O-])C)C(=O)CCC(=O)ON3C(=O)CCC3=O
    InChIKey
    CUTCHWUKZOOSRX-UHFFFAOYSA-N
    InChI
    1S/C23H22N2O8/c1-14-11-17(19(26)7-10-22(29)33-24-20(27)8-9-21(24)28)12-15(2)23(14)32-13-16-3-5-18(6-4-16)25(30)31/h3-6,11-12H,7-10,13H2,1-2H3
    Synonyms
    MFCD11973890 | succinimidyl4-[3,5-dimethyl-4-(4-nitrobenzyloxy)phenyl]-4-oxobutyrate | 2,5-dioxopyrrolidin-1-yl 4-(3,...
  3. 3,5-Dibromo-1,2-phenylenediamine Monohydrochloride [Sensitive reagent for the determination of Se by GC-ECD]
    CAS: 75568-11-5 PubChem CID: 2724285 Formula: C6H6Br2N2·HCl Molecular Weight: 302.39
    Out of Stock Item #: D154953
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    IUPAC Name
    3,5-dibromobenzene-1,2-diamine;hydrochloride
    SMILES
    C1=C(C=C(C(=C1N)N)Br)Br.Cl
    InChIKey
    QOZDVKFQMGARCC-UHFFFAOYSA-N
    InChI
    1S/C6H6Br2N2.ClH/c7-3-1-4(8)6(10)5(9)2-3;/h1-2H,9-10H2;1H
    Synonyms
    3,5-Dibromo-1,2-phenylenediamine Monohydrochloride | 3,5-dibromobenzene-1,2-diamineHydrochloride | A838451 | 1,2-Diam...
  4. 3'-Methoxyphenacyl Bromide [for HPLC Labeling]
    CAS: 5000-65-7 Formula: C9H9BrO2 Molecular Weight: 229.07
    Out of Stock Item #: M158511
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    IUPAC Name
    2-bromo-1-(3-methoxyphenyl)ethanone
    SMILES
    COC1=CC=CC(=C1)C(=O)CBr
    InChIKey
    IOOHBIFQNQQUFI-UHFFFAOYSA-N
    InChI
    1S/C9H9BrO2/c1-12-8-4-2-3-7(5-8)9(11)6-10/h2-5H,6H2,1H3
    Synonyms
    M0815 | AM20060641 | FT-0611417 | 3-Methoxyphenacyl bromide | CQB4BZ4WTK | 2-Bromo-1-(3-methoxyphenyl)ethanone | 2-br...
  5. Nα-(2,4-Dinitro-5-fluorophenyl)-D-valinamide
    CAS: 210529-62-7 Formula: C11H13FN4O5 Molecular Weight: 300.24
    Solid ≥98%(HPLC) sum of enantiomers
    In Stock Item #: N349340
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    Technical Identifiers
    IUPAC Name
    (2R)-2-(5-fluoro-2,4-dinitroanilino)-3-methylbutanamide
    SMILES
    CC(C)C(C(=O)N)NC1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])F
    InChIKey
    ZTFFRKNPAXXEBL-SNVBAGLBSA-N
    InChI
    1S/C11H13FN4O5/c1-5(2)10(11(13)17)14-7-3-6(12)8(15(18)19)4-9(7)16(20)21/h3-5,10,14H,1-2H3,(H2,13,17)/t10-/m1/s1
    Synonyms
    HY-W142141 | DTXSID00583686 | Nalpha-(2,4-Dinitro-5-fluorophenyl)-D-valinamide, for chiral derivatization, >=98.0% | ...
  6. 2,4-Dinitrophenylhydrazine hydrochloride
    CAS: 55907-61-4 EC Number: 259-888-5 Formula: C6H6N4O4·HCl Molecular Weight: 234.6
    ≥98%(HPLC)(T) Used for high-performance liquid chromatography labeling
    In Stock Item #: D155225
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    Technical Identifiers
    IUPAC Name
    (2,4-dinitrophenyl)hydrazine;hydrochloride
    SMILES
    C1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])NN.Cl
    InChIKey
    PUYFAZQODQZOFK-UHFFFAOYSA-N
    InChI
    1S/C6H6N4O4.ClH/c7-8-5-2-1-4(9(11)12)3-6(5)10(13)14;/h1-3,8H,7H2;1H
    Synonyms
    Hydrazine, (2,4-dinitrophenyl)-, monohydrochloride | (2,4-dinitrophenyl)hydrazine hydrochloride | LS-13126 | SY060007...
  7. Girard’s reagent T
    CAS: 123-46-6 EC Number: 204-629-3 Formula: C5H14ClN3O Molecular Weight: 167.64
    In Stock Item #: G108418
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    IUPAC Name
    (2-hydrazinyl-2-oxoethyl)-trimethylazanium;chloride
    SMILES
    C[N+](C)(C)CC(=O)NN.[Cl-]
    InChIKey
    YSULOORXQBDPCU-UHFFFAOYSA-N
    InChI
    1S/C5H13N3O.ClH/c1-8(2,3)4-5(9)7-6;/h4,6H2,1-3H3;1H
    Synonyms
    Q27285753 | 2-Hydrazineyl-N,N,N-trimethyl-2-oxoethan-1-aminium chloride | l-(-)-malicaciddiethylester | girard-t | (H...
  8. O-4-Nitrobenzylhydroxylamine Hydrochloride
    CAS: 2086-26-2 EC Number: 218-228-6 Formula: C7H8N2O3·HCl Molecular Weight: 204.61
    Solid ≥98%
    In Stock Item #: O133067
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    Technical Identifiers
    IUPAC Name
    O-[(4-nitrophenyl)methyl]hydroxylamine;hydrochloride
    SMILES
    C1=CC(=CC=C1CON)[N+](=O)[O-].Cl
    InChIKey
    LKCAFSOYOMFQSL-UHFFFAOYSA-N
    InChI
    1S/C7H8N2O3.ClH/c8-12-5-6-1-3-7(4-2-6)9(10)11;/h1-4H,5,8H2;1H
    Synonyms
    o-(4-nitrobenzyl) hydroxylamine hydrochloride | BDBM50146446 | O-nitrobenzylhydroxylamine | 2-Pentyl alcohol | O-4-NI...
  9. Nα-(2,4-Dinitro-5-fluorophenyl)-L-alaninamide (FDAA)
    CAS: 95713-52-3 EC Number: 635-549-0 Formula: C9H9FN4O5 Molecular Weight: 272.19
    Solid ≥95%(HPLC)
    In Stock Item #: N139491
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    Technical Identifiers
    IUPAC Name
    (2S)-2-(5-fluoro-2,4-dinitroanilino)propanamide
    SMILES
    CC(C(=O)N)NC1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])F
    InChIKey
    NEPLBHLFDJOJGP-BYPYZUCNSA-N
    InChI
    1S/C9H9FN4O5/c1-4(9(11)15)12-6-2-5(10)7(13(16)17)3-8(6)14(18)19/h2-4,12H,1H3,(H2,11,15)/t4-/m0/s1
    Synonyms
    FDAA | BBL102906 | N-(2,4-Dinitro-5-fluorophenyl)-L-alaninamide | N-(Alpha)-(2,4-Dinitro-5-fluorophenyl)-l-alaninamid...
  10. DBD-CO-Hz [=4-(N,N-Dimethylaminosulfonyl)-7-(N-hydrazinocarbonylmethyl-N-methyl)amino-2,1,3-benzoxadiazole] [for HPLC Labeling]
    CAS: 179951-63-4 Formula: C11H16N6O4S Molecular Weight: 328.35
    In Stock Item #: D155221
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    Technical Identifiers
    IUPAC Name
    7-[(2-hydrazinyl-2-oxoethyl)-methylamino]-N,N-dimethyl-2,1,3-benzoxadiazole-4-sulfonamide
    SMILES
    CN(C)S(=O)(=O)C1=CC=C(C2=NON=C12)N(C)CC(=O)NN
    InChIKey
    CCERXXCKPHMFBQ-UHFFFAOYSA-N
    InChI
    1S/C11H16N6O4S/c1-16(2)22(19,20)8-5-4-7(10-11(8)15-21-14-10)17(3)6-9(18)13-12/h4-5H,6,12H2,1-3H3,(H,13,18)
    Synonyms
    DBD-CO-Hz | Glycine, N-[7-[(dimethylamino)sulfonyl]-2,1,3-benzoxadiazol-4-yl]-N-methyl-, hydrazide | SCHEMBL8815211 |...
  11. DBD-COCl [=4-(N,N-Dimethylaminosulfonyl)-7-(N-chloroformylmethyl-N-methylamino)-2,1,3-benzoxadiazole] [for HPLC Labeling]
    CAS: 156153-43-4 Formula: C11H13ClN4O4S Molecular Weight: 332.76
    In Stock Item #: D155215
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    Technical Identifiers
    IUPAC Name
    2-[[4-(dimethylsulfamoyl)-2,1,3-benzoxadiazol-7-yl]-methylamino]acetyl chloride
    SMILES
    CN(C)S(=O)(=O)C1=CC=C(C2=NON=C12)N(C)CC(=O)Cl
    InChIKey
    NAIIBGUHMHXMNS-UHFFFAOYSA-N
    InChI
    1S/C11H13ClN4O4S/c1-15(2)21(18,19)8-5-4-7(16(3)6-9(12)17)10-11(8)14-20-13-10/h4-5H,6H2,1-3H3
    Synonyms
    N-[7-(Dimethylsulfamoyl)-2,1,3-benzoxadiazol-4-yl]-N-methylglycyl chloride | 4-(N-Chloroformylmethyl-N-methyl)amino-7...
  12. Phthaldialdehyde Reagent
    CAS: 643-79-8 EC Number: 211-402-2 Formula: C8H6O2 Molecular Weight: 134.13
    0.8mg/mL solution (pH 10)
    In Stock Item #: P128626
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    Technical Identifiers
    IUPAC Name
    phthalaldehyde
    SMILES
    C1=CC=C(C(=C1)C=O)C=O
    InChIKey
    ZWLUXSQADUDCSB-UHFFFAOYSA-N
    InChI
    1S/C8H6O2/c9-5-7-3-1-2-4-8(7)6-10/h1-6H
    Synonyms
    1,2-Benzenedicarboxaldehyde | o-Phthaldialdehyde | Phthaldialdehyde | Benzene-1,2-dicarboxaldehyde | Phthalic dialdeh...
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R&D Use Only Products supplied for research and development use

Frequently Asked Questions

How do I choose between Derivatization Reagents variants?
Match reagent to substrate compatibility, required selectivity, scalability, and downstream purification needs. Different derivatization reagents have distinct reactivity profiles — review reaction conditions and reported yields for each variant.
What specifications matter for Derivatization Reagents?
Purity, titer (for solution reagents), water content for moisture-sensitive reagents, stabilizer presence, and pack size. Always check certificate of analysis for batch-specific quality data.
How should Derivatization Reagents be stored and handled?
Many synthesis reagents are moisture- or air-sensitive. Store in sealed containers under inert atmosphere when specified. Solution reagents may degrade after multiple openings — aliquot for long-term storage.
Are research and process scales both available?
Yes. Derivatization Reagents are available in gram-scale research quantities through kilogram-scale process supplies. Bulk packaging and custom synthesis options are available on request.

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