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Phosphoglycerat-Dehydrogenase (PHGDH)
CBR 5884 - 10mM in DMSO , CAS No.681159-27-3

CBR 5884 - 10mM in DMSO , CAS No.681159-27-3

Name: CBR 5884 - 10mM in DMSO , CAS No.681159-27-3
SKU: C425422
Availability: InStock

CAS: 681159-27-3 Cat. No.: C425422 Summenformel: C₁₄H₁₂N₂O₄S₂ Molekulargewicht: 336.39 EG-Nummer: 100-774-0

COA

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CBR 5884 - 10mM in DMSO CAS No(681159-27-3) by Aladdin Scientific

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GRADE & PURITY 10mM in DMSO

Synonyms

Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht Specifications Namen und Kennungen Documentation Advanced Data 3D-Struktur Wirkungsmechanismen Zertifikate (CoA, COO, BSE/TSE und Analyse-Diagramm) Chemische und physikalische Eigenschaften Lösungsrechner Bewertungen

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Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Übersicht

Application：

CBR-5884 has been used as a 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor to explore the role of PHGDH in Müller cells from different retinal regions and also used in trypan blue exclusion assay to determine the number of viable MYCN cells.

Specifications

Synonyme

Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50= 33μM). Decreasesde novoserine synthesis in cancer cells. Inhibits proliferation of cancer cell lines having high PHGDH expression levels.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

Pubchem Sid	528763677
Kanonisches Lächeln	CCOC(=O)C1=C(C(=C(S1)NC(=O)C2=CC=CO2)SC#N)C
IUPAC Name	ethyl 5-(furan-2-carbonylamino)-3-methyl-4-thiocyanatothiophene-2-carboxylate
InChIKey	QBVIRPJBDIZKBC-UHFFFAOYSA-N
INCHI	1S/C14H12N2O4S2/c1-3-19-14(18)11-8(2)10(21-7-15)13(22-11)16-12(17)9-5-4-6-20-9/h4-6H,3H2,1-2H3,(H,16,17)
Isomere SMILES	CCOC(=O)C1=C(C(=C(S1)NC(=O)C2=CC=CO2)SC#N)C
Molekulargewicht	336.39
Reaxy-Rn	29216596
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29216596&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

3D-Struktur

Wirkungsmechanismen

Zertifikate (CoA, COO, BSE/TSE und Analyse-Diagramm)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemische und physikalische Eigenschaften

Molekulargewicht	336.400 g/mol
XLogP3	3.600
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Exact Mass	336.024 Da
Monoisotopic Mass	336.024 Da
Topological Polar Surface Area	146.000 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	479.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Lösungsrechner

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