Coprelotamab (anti-ERBB2) - Primärer Antikörper, specific to ERBB2, Human IgG1

CAS: 2348469-84-9 Cat. No.: Ab191934

GRADE & PURITY Animal Free, Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Mensch

Reactive species

Cynomolgus-Affe, Mensch

Isotype

Human IgG1

Conjugation

Unconjugated

Übersicht

Coprelotamab (anti-ERBB2) is humanized monoclonal antibody targated against HER2 with the potential to treat breast cancer.

Specifications

Product Name

Coprelotamab (anti-ERBB2) - Primärer Antikörper, specific to ERBB2, Human IgG1

Synonyme

Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody | C erb B2/neu protein antibody | CD340 antibody | CD340 antigen antibody | Cerb B2/neu protein antibody | GB-221 | v-erb-b2 erythroblastic leuk

Spezifikationen & Reinheit

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Biochemische und physiologische Mechanismen

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a

Wirtsspezies

Mensch

Spezifität

ERBB2

Konjugation

Unconjugated

Note

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Isotyp

Human IgG1

Lichterketten-Typ

kappa

SDS-PAGE

145 kDa

Verfahren zur Reinigung

Protein A purified

Konzentration

See COA

CAS

2348469-84-9

Product Line

Biologische Produkte

Lagerung und Versand

Storage

Store at -80°C,Avoid repeated freezing and thawing

Verschickt in

Dry ice packs + Cold packs

Stabilität und Lagerung

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Bilder

Flow Cytometry: Coprelotamab (anti-ERBB2) (Ab191934)

Coprelotamab (anti-ERBB2) (Ab191934) - Flow Cytometry
Flow Cytometry analysis of MCF7 cells labelling ERBB2 (red) with Coprelotamab (anti-ERBB2) (Ab191934) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

ELISA: Coprelotamab (anti-ERBB2) (Ab191934)

Coprelotamab (anti-ERBB2) (Ab191934) - ELISA
Immobilized Recombinant Human ErbB2/HER2 protein (rp169607) at 1.0 μg/mL can bind Coprelotamab (anti-ERBB2) (Ab191934) with the EC₅₀0 of 20.25 ng/mL.

SEC: Coprelotamab (anti-ERBB2) (Ab191934)

Coprelotamab (anti-ERBB2) (Ab191934) - SEC
The purity of Coprelotamab (anti-ERBB2) (Ab191934) is more than 95% verified by HPLC.

Zugehörige Ziele (menschlich)

ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 (0 Activities)

Discover Target: ERBB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)

Discover Target: ERBB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERBB2 Tclin Epidermal growth factor receptor and ErbB2 (HER1 and HER2) (186 Activities)

Discover Target: ERBB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERBB2 Tclin Epidermal growth factor receptor (487 Activities)

Discover Target: ERBB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERBB2 Tclin FASN/HER2 (2 Activities)

Discover Target: ERBB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Häufig gestellte Fragen

What does Animal Free mean?

Animal Free indicates that the material has been processed and tested for specialty industrial processing. Specifications focus on the impurities that affect performance in that application — for example, metal content for electronics, particle size for batteries, refractive index for optics, or moisture content for moisture-sensitive processes.

How should this product be stored?

Store at ?80 °C. Avoid repeated freeze–thaw cycles. Aliquot into single-use volumes before freezing.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2348469-84-9.

What does Carrier Free mean?

Carrier Free indicates that the material has been processed and tested for specialty industrial processing. Specifications focus on the impurities that affect performance in that application — for example, metal content for electronics, particle size for batteries, refractive index for optics, or moisture content for moisture-sensitive processes.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

Which species reactivity has this antibody been validated against?

Validated reactivity is listed on the PDP and on each lot's datasheet. We validate against the most commonly tested species for the target (Coprelotamab (anti-ERBB2)); cross-reactivity in untested species may exist but is not guaranteed. Contact technical support for specific species inquiries.