Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Desiccated,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 12 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a K i value of 5.8 μM and an IC 50 value of 6.3 μM. Coptisine chloride is a potent H1N1 neuraminidase (NA-1) inhibitor with an IC 50 of 104.6?μg/mL and can be used for influenza A (H1N1) infection .
| Isomeric SMILES | C1C[N+]2=C(C=C3C=CC4=C(C3=C2)OCO4)C5=CC6=C(C=C51)OCO6.[Cl-] |
|---|---|
| Molecular Weight | 355.77 |
| Reaxy-Rn | 4118452 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4118452&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Melt Point(°C) | 218°C |
|---|
| 1. Jin Pian, Zhu Fucheng, Zhou Wen, Liu Chen, Li Na, Liu Houmei. (2023) Developing magnetic functionalized dendritic fibrous mesoporous silica as advanced adsorbent for quaternary ammonium alkaloids. MICROCHIMICA ACTA, 190 (12): (1-12). [PMID:37999777] [10.1007/s00604-023-06053-x] |
| 2. Yang Gao, Shi-Qiao Liu, Jia-Long Wang, Han-Ming Cui, Qiu-Yan Zhang, Lei Wang, Yi-Xin Zhang, Jian Li, Yu Dong, Yuan-Hui Hu. (2023) Vitro UPLC analysis and mass method identification, and in vivo or cellular immune anti-inflammatory function of Sanhuang Xiexin Decoction (SHXD). JOURNAL OF ETHNOPHARMACOLOGY, [PMID:37544343] [10.1016/j.jep.2023.117002] |
| 3. Longlong Gao, Rui Tian, Yong Shao. (2023) Photocatalytic Duplex-Based DNAzymes Switched by an Abasic Site. Chemistry-Switzerland, 5 (3): (1497-1507). [PMID:] [10.3390/chemistry5030102] |
| 4. Jiajia Zhai, Zeping Li, Huifeng Zhang, Zuowei Lu, Yi Zhang, Mo Li, Jian Kang, Zelong Yang, Louyan Ma, Li Ma, Zhengquan Ma, Xiaorui Ma, Fanghong Zhao, Xiaoqing Ma, Yuan Gao, Yuanyuan Zhang, Xiaomiao Li. (2023) Coptisine mitigates diabetic nephropathy via repressing the NRLP3 inflammasome. Open Life Sciences, 18 (1): [PMID:37197172] [10.1515/biol-2022-0568] |
| 5. Huanyu Guan, Pengfei Li, Qian Wang, Fanli Zeng, Jiashuo Wu, Fangqing Zhang, Shanggao Liao, Yue Shi. (2022) Deciphering the chemical constituents of Shengjiang Xiexin decoction by ultrahigh-performance liquid chromatography-quadrupole/orbitrap high-resolution mass spectrometry and the impact of 20 characteristic components on multidrug resistance-associated protein 2 in the vesicular transport assay. JOURNAL OF SEPARATION SCIENCE, 45 (18): (3459-3479). [PMID:35838583] [10.1002/jssc.202200370] |
| 6. Yingxin Chen, Xiaotong Huang, Lu Li, Junxian Wu, Yongqi Guo, Yachao Yao, Lihua Zhou. (2022) Paper mill sludge-based carbon quantum dots as a specifically ratiometric fluorescent probe for the sensitive and selective detection of coptisine. LUMINESCENCE, 37 (7): (1078-1086). [PMID:35441456] [10.1002/bio.4260] |
| 7. Lu Shao Hua, Zhang Ming Cai, Zhai Hong Lin, Bi Ke Xin, Zhao Bing Qiang. (2022) Rapid Determination in the Quality Control of Chinese Patent Medicine. Journal of Pharmaceutical Innovation, 17 (4): (1305-1313). [PMID:] [10.1007/s12247-021-09608-8] |
| 8. Kun Yan, Lancheng Wang, Huimin Zhou, Zhendong Hua, Peng Xu, Hui Xu, Youmei Wang, Bin Di, Chi Hu. (2021) Cucurbituril-mediated AIE: An unconventional indicator displacement assay for ketamine detection. DYES AND PIGMENTS, [PMID:] [10.1016/j.dyepig.2021.109875] |
| 9. Hanzhi Zhang, Chunli Lou, Jing Li, Jingwu Kang. (2020) A gold foil covered fused silica capillary tip as a sheathless interface for coupling capillary electrophoresis-mass spectrometry. JOURNAL OF CHROMATOGRAPHY A, [PMID:32540065] [10.1016/j.chroma.2020.461215] |
| 10. Yuehua Hu, Fan Lin, Tao Wu, Ying Wang, Xiao-Shun Zhou, Yong Shao. (2016) Fluorescently Sensing of DNA Triplex Assembly Using an Isoquinoline Alkaloid as Selector, Stabilizer, Inducer, and Switch-On Emitter. Chemistry-An Asian Journal, 11 (14): (2041-2048). [PMID:27252050] [10.1002/asia.201600459] |
| 11. Ting Tan, Mingliang Zhang, Yiqun Wan, Hongdeng Qiu. (2015) Utilization of deep eutectic solvents as novel mobile phase additives for improving the separation of bioactive quaternary alkaloids. TALANTA, [PMID:26717817] [10.1016/j.talanta.2015.11.041] |
| 12. Wenpeng Zhang, Zilin Chen. (2012) Preparation of micropipette tip-based molecularly imprinted monolith for selective micro-solid phase extraction of berberine in plasma and urine samples. TALANTA, [PMID:23200364] [10.1016/j.talanta.2012.10.014] |
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