Dabigatran ethyl ester hydrochloride - 10mM in DMSO , CAS No.211914-50-0

CAS: 211914-50-0 Cat. No.: D656814 Molecular Weight: 536.04 EC Number: 801-940-1 PubChem CID: 18412337

GRADE & PURITY 10mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Dabigatran ethyl ester hydrochloride is a potent inhibitor of ribosyldihydronicotinamide dehydrogenase ( NQO2 ) with an IC 50 value of 0.8 μM and a thrombin inhibitor.

In Vitro

The K i of dabigatran (ethyl ester hydrochloride) toward NQO2 is 0.9 μM and the IC 50 is 0.8 μM. The ethyl ester group of dabigatran (ethyl ester hydrochloride) significantly extends the interaction surface especially with hydrophobic amino acids such as Ile 128 and Met 154. Dabigatran ethyl ester has higher affinity than Dabigatran to both thrombin and NQO2. Dabigatran is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dabigatran (K i =4.5 nM) could bind to human thrombin selectively, and reversibly to realize a strong and long-lasting anticoagulant effect. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 0.8 μM (NQO2)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Dabigatran ethyl ester hydrochloride is a potent inhibitor of ribosyldihydronicotinamide dehydrogenase ( NQO2 ) with an IC 50 value of 0.8 μM and a thrombin inhibitor.

Storage

Desiccated, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: CCOC(=O)CCN(C1=CC=CC=N1)C(=O)C2=CC3=C(C=C2)N(C(=N3)CNC4=CC=C(C=C4)C(=N)N)C.Cl
• PubChem CID: 18412337
• Molecular Weight: 536.04